above the south coast. In the eastern portion of the island were From this time Crete continued subject to Ottoman rule without interruption till the outbreak of the Greek revolution. After the conquest a large part of the inhabitants embraced Mahommedanism, and thus secured to themselves the chief share in the administration of the island. But far from this having a favourable effect upon the condition of the population, the result was just the contrary, and according to R. Pashley (Travels in Crete, 1837) Crete was the worst governed province of the Turkish empire. In 1770 an abortive attempt at revolt, the hero of which was "Master" John, a Sphakiot chief, was repressed with great cruelty. The regular authorities sent from Constantinople were wholly unable to control the excesses of the janissaries, who exercised without restraint every kind of violence and oppression. In 1813 the ruthless severity of the governor-general, Haji Osman, who obtained the co-operation of the Christians, broke the power of the janissaries; but after Osman had fallen a victim to the suspicions of the sultan, Crete again came under their control. When in 1821 the revolution broke out in continental Greece, the Cretans, headed by the Sphakiots, after a massacre at Canea at once raised the standard of insurrection. They carried on hostilities with such success that they soon made themselves masters of the whole of the open country, and drove the Turks and Mussulman population to take refuge in the fortified cities. The sultan then invoked the assistance of Mehemet Ali, pasha of Egypt, who despatched 7000 Albanians to the island. Hostilities continued with no decisive result till 1824, when the arrival of further reinforcements enabled the Turkish commander to reduce the island to submission. In 1827 the battle of Navarino took place, and in 1830 (3rd of February) Greece was declared independent. The allied powers (France, England and Russia) decided, however, that Crete should not be included amongst the islands annexed to the newly-formed kingdom of Greece; but recognizing that some change was necessary, they obtained from the sultan Mahmud II. its cession to Egypt, which was confirmed by a firman of the 20th of December 1832. This change of masters brought some relief to the unfortunate Cretans, who at least exchanged the licence of local misrule for the oppression of an organized despotism; and the government of Mustafa Pasha, an Albanian like Mehemet Ali, the ruler of the island for intelligent than that of most Turkish governors. He encouraged agriculture, improved the roads, introduced an Albanian police, and put down brigandage. The period of his administration has been called the "golden age' of Crete. Under the Venetian government Candia, a fortress originally built by the Saracens, and called by them "Khandax,” became the seat of government, and not only rose to be the capital and chief city of the island, but actually gave name to it, so that it was called in the official language of Venice "the island of Candia," a designation which from thence passed into modern maps. The ancient name of Krete or Kriti was, however, always retained in use among the Greeks, and is gradually resuming its place in the usage of literary Europe. The government of Crete by the Venetian aristocracy was, like that of their other de-a considerable period (1832-1852), was more enlightened and pendencies, very arbitrary and oppressive, and numerous insurrections were the consequence. Daru, in his history of Venice, mentions fourteen between the years 1207 and 1365, the most important being that of 1361-1364,—a revolt not of the natives against the rule of their Venetian masters, but of the Venetian colonists against the republic. But with all its defects their administration did much to promote the material prosperity of the country, and to encourage commerce and industry; and it is probable that the island was more prosperous than at any subsequent time. Their Venetian masters at least secured to the islanders external tranquillity, and it is singular that the Turks were content to leave them in undisturbed possession of this opulent and important island for nearly two centuries after the fall of Constantinople. The Cretans themselves, however, were eager for a change, and, disappointed in the hope of a Genoese occupation, were ready, as is stated in the report of a Venetian commissioner, to exchange the rule of the Venetians for that of the Turks, whom they fondly expected to find more lenient, or at any rate less energetic, masters. It was not till 1645 that the Turks made any serious attempt to effect the conquest of the island; but in that year they landed with an army of 50,000 men, and speedily reduced the important city of Canea. Retimo fell the following year, and in 1648 they laid siege to the capital city of Candia. This was the longest siege on record, having been protracted for more than twenty years; but in 1667 it was pressed with renewed vigour by the Turks under the grand vizier Ahmed Kuprili, and the city was at length compelled to surrender (September 1669). Its fall was followed by the submission of the whole island. Venice was allowed to retain possession of Grabusa, Suda and Spinalonga on the north, but in 1718 these three strongholds reverted to the Turks, and the island was finally lost to Venice. In 1840 Crete was again taken from Mehemet Ali, and replaced under the dominion of the Turks, but fortunately Mustafa still retained his governorship until he left for Constantinople to become grand vizier in 1852. Four years later an insurrection broke out, owing to the violation of the provisions of an imperial decree (February 1856), whereby liberty of conscience and equal rights and privileges with Mussulmans had been conferred upon Christians. The latter refused to lay down their arms until a firman was issued (July 1858), confirming the promised concessions. These promises being again repudiated, in 1864 the inhabitants held an assembly and a petition was drawn up for presentation at Constantinople by the governor. The sultan's reply was couched in the vaguest terms, and the Cretans were ordered to render unquestioning obedience to the authorities. After a period of great distress and cruel oppression, in 1866, on the demand for reforms being again refused, a general insurrection took place, which was only put down by great exertions on the part of the Porte. It was followed by the concession of additional privileges to the Christians of the island and of a kind of constitutional government and other reforms embodied in what is known as the "Organic Statute" of 1868. (J. H. F.) Modern Constitutional.-Cretan constitutional history may be said to date from 1868, when, after the suppression of an insurrection which had extended over three years, the Turkish government consented to grant a certain measure of autonomy to the island. The privileges now accorded were embodied in what is known as the Organic Statute, an instrument which eventually obtained a somewhat wider importance, being proposed by Pact of Halepa. Article XXIII. of the Berlin Treaty as a basis of reforms to be introduced in other parts of the Ottoman empire. Various privileges already acquired by the Christian population were confirmed; a general council, or representative body, was brought into existence, composed of deputies from every district in the island; mixed tribunals were introduced, together with a highly elaborate administrative system, under which all the more important functionaries, Christian and Mussulman, were provided with an assessor of the opposite creed. The new constitution, however, proved costly and unworkable, and failed to satisfy either section of the population. The Christians were ready for another outbreak, when, in 1878, the Greek government, finding Hellenic aspirations ignored by the treaty of San Stefano, gave the signal for agitation in the island. During the insurrection which followed, the usual barbarities were committed on both sides; the Christians betook themselves to the mountains, and the Mussulman peasants crowded into the fortified towns. Eventually the Cretan chiefs invoked the mediation of England, which Turkey, exhausted by her struggle with Russia, was ready to accept, and the convention known as the Pact of Halepa was drawn up in 1878 under the auspices of Mr Sandwith, the British consul, and Adossides Pasha, both of whom enjoyed the confidence of the Cretan population. The privileges conferred by the Organic Statute were confirmed; the cumbersome and extravagant judicial and administrative systems were maintained; the judges were declared independent of the executive, and an Assembly composed of forty-nine Christian and thirty-one Mussulman deputies took the place of the former general council. A parliamentary régime was thus inaugurated, and party warfare for a time took the place of the old religious antagonism, the Moslems attaching themselves to one or other of the political factions which now made their appearance among the Christians. The material interests of the island were neglected in the scramble for place and power; the finances fell into disorder, and the party which came off worst in the struggle systematically intrigued against the governor-general of the day and conspired with his enemies at Constantinople. A crisis came about in 1889, when the "Conservative" leaders, finding themselves in a minority in the chamber, took up arms and withdrew to the mountains. Though the outbreak was unconnected with the religious feud, the latent fanaticism of both creeds was soon aroused, and the island once more became a scene of pillage and devastation. Unlike the two preceding movements, the insurrection of 1889 resulted unfavourably for the Christians. The Porte, having induced the Greek government to persuade the insurgents not to oppose the occupation of several strategic posts, despatched a military governor to the island, proclaimed martial law, and issued a firman abrogating many important provisions of the Halepa Pact. The mode of election to the assembly was altered, the number of its members reduced, and the customs revenue, which had hitherto been shared with the island, was appropriated by the Turkish treasury. The firman was undoubtedly illegal, as it violated a convention possessing a quasi-international sanction, but the Christians were unable to resist, and the powers abstained from intervention. The elections held under the new system proved a failure, the Christians refusing to go to the polls, and for the next five years Crete was governed absolutely by a succession of Mahommedan Valis. The situation went from bad to worse, the deficit in the budget increased, the gendarmery, which received no pay, became insubordinate, and crime multiplied. In 1894 the Porte, at the instance of the powers, nominated a Christian, Karatheodory Pasha, to the governorship, and the Christians, mollified by the concession, agreed to take part in the assembly which soon afterwards was convoked; no steps, however, were taken to remedy the financial situation, which became the immediate cause of the disorders that followed. The refusal of the Porte to refund considerable sums which had been illegally diverted from the Cretan treasury or even to sanction a loan to meet immediate requirements caused no little exaspera- | tion in the island, which was increased by the recall of Karatheodory (March 1895). Before that event an Epitropé, or Insurrection of 1896-97. "Committee of Reform," had appeared in the mountains--the harbinger of the prolonged struggle which ended in the emanci pation of Crete. The Epitropé was at first nothing more than a handful of discontented politicians who had failed to find places in the administration, but some slight reverses which it succeeded in inflicting on the Turkish troops brought thousands of armed Christians to its side, and in April 1896 it found itself strong enough to invest the important garrison town of Vamos. The Moslem peasantry now flocked to the fortified towns and civil war began. Serious disturbances broke out at Canea on the 24th of May, and were only quelled by the arrival of foreign warships. The foreign consuls intervened in the hope of bringing about a peaceful settlement, but the Sultan resolved on the employment of force, and an expedition despatched to Vamos effected the relief of that town with a loss of 200 men. The advance of a Turkish detachment through the western districts, where other garrisons were besieged, was marked by pillage and devastation, and 5000 Christian peasants took refuge on the desolate promontory of Spada, where they suffered extreme privations. These events, which produced much excitement in Greece, quickened the energies of the powers. An international blockade of the island was proposed by Austria but rejected by England. The ambassadors at Constantinople urged peaceful counsels on the Porte, and the Sultan, alarmed at this juncture by an Armenian outbreak, began to display a conciliatory disposition. The Pact of Halepa was restored, the troops were withdrawn from the interior, financial aid was promised to the island, a Christian governor-general was appointed, the assembly was summoned, and an imperial commissioner was despatched to negotiate an arrangement. The Christian leaders prepared a moderate scheme of reforms, based on the Halepa Pact, which, with a few exceptions, were approved by the powers and eventually sanctioned by the sultan. On the 4th of September 1896 the assembly formally accepted the new constitution and declared its gratitude to the powers for their intervention. The Moslem leaders acquiesced in the arrangement, which the powers undertook to guarantee, and, notwithstanding some symptoms of discontent at Candia, there was every reason to hope that the island was now entering upon a period of tranquillity. It soon became evident, however, that the Porte was endeavouring to obstruct the execution of the new reforms. Several months passed without any step being taken towards this realization; difficulties were raised with regard to the composition of the international commissions charged with the reorganization of the gendarmery and judicial system; intrigues were set on foot against the Christian governorgeneral; and the presence of a special imperial commissioner, who had no place under the constitution, proved so injurious to the restoration of tranquillity that the powers demanded his immediate recall. The indignation of the Christians increased, a state of insecurity prevailed, and the Moslem peasants refused to return to their homes. A new factor now became apparent in Cretan politics. Since the outbreak in May 1896 the Greek government had loyally co-operated with the powers in their efforts for the pacification of the island, but towards the close of the year a secret society known as the Ethniké Hetaeria began to arrogate to itself the direction of Greek foreign policy. The aim of the society was a war with Turkey with a view to the acquisition of Macedonia, and it found a ready instrument for its designs in the growing discontent of the Cretan Christians. Emissaries of the society now appeared in Crete, large consignments of arms were landed, and at the beginning of 1897 the island was practically in a state of insurrection. On the 21st of January the Greek fleet was mobilized. Affairs were brought to a climax by a series of conflicts which took place at Canea on the 4th of February; the Turkish troops fired on the Christians, a conflagration broke out in the town, and many thousands of Christians took refuge on the foreign warships in the bay. The Greek government now despatched an ironclad and a cruiser to Canea, which were followed a few days later by a torpedo flotilla commanded by Greek intervention. Decision of the powers. standard of revolt at Theriso in the White Mountains. The Prince George. The prince soon retired to Melos, but on the night | year a band of armed malcontents under M. Venezelo raised the of the 14th of February a Greek expeditionary force under Colonel Vassos landed at Kolymbari, near Canea, and its commander issued a proclamation announcing the occupation of the island in the name of King George. On the same day Georgi Pasha, the Christian governor-general, took refuge on board a Russian ironclad, and, on the next, naval detachments from the warships of the powers occupied Canea. This step paralysed the movements of Colonel Vassos, who after a few slight engagements with the Turks remained practically inactive in the interior. The insurgents, however, continued to threaten the town, and their position was bombarded by the international fleet (21st February). The intervention of Greece caused immense excitement among the Christian population, and terrible massacres of Moslem peasants took place in the eastern and western districts. The forces of the powers shortly afterwards occupied Candia and the other maritime towns, while the international fleet blockaded the Cretan coast. These measures were followed by the presentation of collective notes to the Greek and Turkish governments (2nd March), announcing the decision of the powers that (1) Crete could in no case in present circumstances be annexed to Greece; (2) in view of the delays caused by Turkey in the application of the reforms Crete should now be endowed with an effective autonomous administration, intended to secure to it a separate government, under the suzerainty of the sultan. Greece was at the same time summoned to remove its army and fleet from the island, while the Turkish troops were to be concentrated in the fortresses and eventually withdrawn. The cabinet of Athens, however, declined to recall the expeditionary force, which remained in the interior till the 9th of May, when, after the Greek reverses in Thessaly and Epirus, an order was given for its return. Meantime Cretan autonomy had been proclaimed (20th March). After the departure of the Greek troops the Cretan leaders, who had hitherto demanded annexation to Greece, readily acquiesced in the decision of the powers, and the insurgent Assembly, under its president Dr Sphakianakis, a man of good sense and moderation, co-operated with the international commanders in the maintenance of order. The pacification of the island, however, was delayed by the presence of the Turkish troops and the inability of the powers to agree in the choice of a new governorgeneral. The prospect of a final settlement was improved by the withdrawal of Germany and Austria, which had favoured Turkish pretensions, from the European concert (April 1898); the re-offended both parties; but on the whole his administration was maining powers divided the island into four departments, which they severally undertook to administer. An attack made by the Moslems of Candia on the British garrison of that town, with the connivance of the Turkish authorities, brought home to the powers the necessity of removing the Ottoman troops, and the last Turkish soldiers quitted the island on the 14th of November 1898. Prince George's adminis On the 26th of that month the nomination of Prince George of Greece as high commissioner of the powers in Crete for a period of three years (renewed in 1901) was formally announced, and on the 21st of December the prince landed at Suda and made his public entry into Canea tration. amid enthusiastic demonstrations. For some time after his arrival complete tranquillity prevailed in the island, but the Moslem population, reduced to great distress by the prolonged insurrection, emigrated in large numbers. On the 27th of April 1899 a new autonomous constitution was voted by a constituent assembly, and in the following June the local administration was handed over to Cretan officials by the international authorities. The extensive powers conferred by the constitution upon Prince George were increased by subsequent enactments. In 1901 M. Venezelo, who had played a noteworthy part in the last insurrection, was dismissed from the post of councillor by the prince, and soon afterwards became leader of a strong opposition party, which denounced the arbitrary methods of the government. During the next four years party spirit ran high; in the spring of 1904 a deputation of chiefs and politicians addressed a protest to the prince, and early in the following On the 22nd of February 1907 M. Zaimis, as high commissioner, took the oath to the new constitution elaborated after much debate by the Cretan national assembly. His position was one of singular difficulty. Apart from the rivalry of the factions within the Assembly, there was the question of the Mussulman minority, dwindling it is true,' but still a force to be reckoned with. The high commissioner, true to his reputation as a prudent statesman and astute politician, showed great skill in dealing with the situation. From the first he had taken up an attitude of great reserve, appearing little in public and careful not to identify himself with any faction. In such matters as appointments to the judicial bench, indeed, his studied impartiality a marked success, and the cessation of the chronic state of disturbance in the island justified the powers in preparing for the withdrawal of their troops. In spite of the admission of their co-religionists to high office in the government, the Mussulmans, it is true, still complained of continuous ill-treatment having for its object their expatriation; but these complaints were declared by Sir Edward Grey, in answer to a question in parliament, to be exaggerated. The protecting powers had fixed the conditions preliminary to evacuation-(1) the organization of a native gendarmerie, (2) the maintenance of the tranquillity of the island, (3) the complete security of the Mussulman population. On the 20th of March 1908 M. Zaimis called the attention of the powers to the fact that these conditions had been fulfilled, and on the 11th of May the powers announced to the high commissioner their intention of beginning the evacuation at once and completing it within a year. The first withdrawal of the troops (July 27), hailed with enthusiasm by the Cretan Christians, led to rioting by the Mussulmans, who believed themselves abandoned to their fate. Meanwhile M. Zaimis had made a further advance towards the annexation of the island to Greece by a visit to Athens, where he arranged for a loan with the Greek National Bank and engaged Greek officers for the new gendarmerie. The issue was precipitated by the news of the revolution in Turkey. On the 12th in 1907, and the emigration was still continuing. The loss to the 1 The Mussulman population, 88,000 in 1895, had sunk to 40,000 country in wealth exported and land going out of cultivation has been very serious. of October the Cretan Assembly once more voted the union with | be due to drinking certain waters, though the particular impurity Greece, and in the absence of M. Zaimis-who had gone for a in the water which gives rise to this condition has not been holiday to Santa Maura-elected a committee of six to govern determined (see GOITRE). The causation of the sporadic form the island in the name of the king of Greece. of cretinism is, however, obscure. Against this the Mussulman deputies protested, in a memorandum addressed to the British secretary of state for foreign affairs. His reply, while stating that his government would safeguard the interests of the Mussulmans, left open the question of the attitude of the powers, complicated now by sympathy with reformed Turkey. The efforts of diplomacy were directed to allaying the resentment of the "Young Turks" on the one hand and the ardour of the Greek unionists on the other; and meanwhile the Cretan administration was carried on peaceably in the name of King George. At last (July 13, 1909) the powers announced to the Porte, in answer to a formal remonstrance, their decision to withdraw their remaining troops from Crete by July 26 and to station four war-ships off the island to protect the Moslems and to safeguard "the supreme rights" of the Ottoman Empire. This arrangement, which was duly carried out, was avowedly "provisional and satisfied neither party, leading in Greece especially to the military and constitutional crises of 1909 and 1910. (W. A. P.) AUTHORITIES.-Pashley, Travels in Crete (2 vols., Cambridge and London, 1837); Spratt, Travels and Researches in Crete (2 vols., London, 1867); Raulin, Description physique de l'île de Crète (3 vols. and Atlas, Paris, 1869); W. J. Stillman, The Cretan Insurrection of 1866-68 (New York, 1874); Edwardes, Letters from Crete (London, 1887); Stavrakis, ETαTιOTIKη toû ñànůvσμoû Tŷs Kρýτns (Athens, 1890); J. H. Freese, A Short Popular History of Crete (London, 1897); Bickford-Smith, Cretan Sketches (London, 1897); Laroche, La Crète ancienne et moderne (Paris, 1898); Victor Berard, Les Affaires de Crète (Paris, 1898); Monumenti Veneti dell' isola de Creta (published by the Venetian Institute), vol. i. (1906), vol. ii. (1908). See also Mrs Walker, Eastern Life and Scenery (London, 1886), and Old Tracks and New Landmarks (London, 1897); H. F. Tozer, The Islands of the Aegean (Oxford, 1890); J. D. Bourchier, "The Stronghold of the Sphakiotes," Fortnightly Review (August 1890); E. J. Dillon," Crete and the Cretans," Fortnightly Review (May 1897). CRETINISM, the term given to a chronic disease, either sporadic or endemic, arising in early childhood, and due to absence or deficiency of the normal secretion of the thyroid gland. It is characterized by imperfect development both of mind and body. The thyroid gland is either congenitally absent, imperfectly developed, or there is definite goitre. The origin of the word is doubtful. Its southern French form Chrestiaa suggested to Michel a derivation from cresta (crête), the goose foot of red cloth worn by the Cagots of the Pyrenees. The Cagots, however, were not cretins. The word is usually explained as derived from chrétien (Christian) in the sense of "innocent." But Christianus (which appears in the Lombard cristanei; compare the Savoyard innocents and gens du bon dieu) is probably a translation of the older cretin, and the latter is probably connected with creta (craie)—a sallow or yellow-earthy complexion being a common mark of cretinism. The endemic form of cretinism prevails in certain districts, as in the valleys of central Switzerland, Tirol and the Pyrenees. In the United Kingdom cretins have been found in England at Oldham, Sholver Moor, Crompton, Duffield, Cromford (near Matlock), and other points in Derbyshire; endemic goitre has been seen near Nottingham, Chesterfield, Pontefract, Ripon, and the mountainous parts of Staffordshire and Yorkshire, the east of Cumberland, certain parts of Worcester, Warwick, Cheshire, Monmouth, and Leicester, near Horsham in Hampshire, near Haslemere in Surrey, and near Beaconsfield in Buckingham. There are cretins at Chiselborough in Somerset. In Scotland cretins and cases of goitre have been seen in Perthshire, on the east coast of Fife, in Roxburgh, the upper portions of Peebles and Selkirk, near Lanark and Dumfries, in the east of Ayrshire, in the west of Berwick, the east of Wigtown, and in Kirkcudbright. The disease is not confined to Europe, but occurs in North and South America, Australia, Africa and Asia. Wherever endemic goitre is present, endemic cretinism is present also, and it has been constantly observed that when a new family moves into a goitrous district, goitre appears in the first generation, cretinism in the second. The causation of goitre has now been shown to Cretinism usually remains unrecognized until the child reaches some eighteen months or two years, when its lack of mental development and uncouth bodily form begin to attract attention. Occasionally the child appears to be normal in infancy, but the cretinoid condition develops later, any time up to puberty. The essential point in the morbid anatomy of these cases is the absence or abnormal condition of the thyroid gland (see METABOLIC DISEASES). It may be congenitally absent, atrophied, or the seat of a goitre, though this last condition is very rare in cases of sporadic cretinism. The skeleton shows arrested growth, most marked in the case of the long bones. The skull in the endemic form of cretinism is usually brachycephalic, but in the sporadic cases it is more commonly dolichocephalic. The pathology of cretinism and its allied condition myxoedema (q.v.) has now been conclusively worked out, and its essential cause has been shown to be loss of function of the thyroid gland. The condition has existed and been described in far back ages, but mingled with so many other entirely different deformities and degenerations that it is now often almost impossible to classify them satisfactorily. The following is a vivid picture by Beaupré (Dissertation sur les crétins, translated in Blackie on Cretinism, Edin., 1855): "I see a head of unusual form and size, a squat and bloated figure, a stupid look, bleared hollow and heavy eyes, thick projecting eyelids, and a flat nose. His face is of a leaden hue, his skin dirty, flabby, covered with tetters, and his thick tongue hangs down over his moist livid lips. His mouth, always open and full of saliva, shows teeth going to decay. His chest is narrow, his back curved, his breath asthmatic, his limbs short, misshapen, without power. The knees are thick and inclined inward, the feet flat. The large head drops listlessly on the breast; the abdomen is like a bag.' When fully grown the height rarely exceeds 4 ft., and is often less than 3 ft. The skin feels doughy from thickening of the subcutaneous tissues, and it hangs in folds over the abdomen and the bends of the joints. Very frequently there is an umbilical hernia. The hair has a far greater resemblance to horse-hair than to that of a human being, and is usually absent on the body of an adult cretin. The temperature is subnormal, and the exposed parts tend to become blue in cold weather. The blood is usually deficient in haemoglobin, which is often only 40-50 % of the normal. The mental capacity varies within narrow limits; an intelligent adult cretin may reach the intellectual development of a child 3-4 years of age, though more often the standard attained is even below this. The child cretin learns neither to walk nor talk at the usual time. Often it is unable even to sit without support. Some years later a certain power of movement is acquired, but the gait is waddling and clumsy. Speech is long delayed, or in bad cases may be almost entirely lacking. The voice is usually harsh and unpleasant. Of the senses smell and taste are but slightly developed, more or less deafness is generally present, and only the sight is fairly normal. In the adult the genital organs remain undeveloped. If the cretin is untreated he rarely has a long life, thirty years being an exceptional age. Death results from some intercurrent disease. Cretinism has to be distinguished from the state of a Mongolian idiot, in whom there is no thickening of the subcutaneous tissues, and much greater alertness of mind; from achondroplasia, in which condition there is usually no mental impairment; and from infantilism, which covers a group of symptoms whose only common point is that the primary and secondary sexual characteristics fail to appear at the proper time. after applied to cretinism and its effects were found to be even more wonderful. It has to be used, however, with the greatest care and discrimination, since personal idiosyncrasy seems to be a very variable factor. Even small doses, if beyond the patient's power, may produce fever, excitement, headache, insomnia and vomiting. The administration must be persisted in throughout life, otherwise myxoedematous symptoms appear. The first most apparent results are those of growth, and this may supervene even in patients up to 25-30 years of age. Once started, 4 to 6 in. may be gained in stature in the first year's treatment, though this is usually in inverse ratio to the age of the patient, and also diminishes in later stages of treatment. In young adolescents it may be so rapid that the patient has to be kept lying down to prevent permanent bending of the long bones of the leg, softened by their rapid growth. A very typical case under Dr Hector Mackenzie, showing what can be expected from early treatment, is that of a cretin aged 11 years in 1893, when thyroid treatment was started. He grew very rapidly and became a normal child, passed through school, and in 1908 was at one of the universities. BIBLIOGRAPHY.-Sardinian Commission, "Relazione della commissione di Sardegna per studiare il cretinismo (Torino, 1848); C. Hilton Fagge, On Sporadic Cretinism occurring in England,' Med. Chir. Trans. (London, 1870); Vincenzo Allara, "Sulla causa del cretinesimo," studio (Milano, 1892); Victor Horsley, Remarks on the Function of the Thyroid Gland," Brit. Med. Journ. (1892); "The Treatment of Myxoedema and Cretinism, being a Review of the Treatment of those Diseases by Thyroid Gland," Journ. Ment. Sc. (London, 1893); W. Osler, " On Sporadic Cretinism in America,' Am. Journ. of Med. Sc. (1893); C. A. Ewald, Die Erkrankungen der Schilddrüse, Myxödeme und Cretinismus (Wien, 1896); G. R. Murray, Diseases of the Thyroid Gland, part i. (1900); R. Virchow, Über Cretinismus," Würzburger Verhand.; Hector Mackenzie, Organotherapy, "Textbook of Pharmacology and Therapeutics (1901); Weygandt, Der heutige Stand der Lehre vom Kretinismus (Halle, 1903); Hector Mackenzie," Cretinism," Allbutt & Rolleston's System of Medicine, part iv. (1908). CRETONNE, originally a strong, white fabric with a hempen warp and linen weft. The word is said to be derived from Creton, a village in Normandy where the manufacture of linen was carried on.. It is now applied to a strong, printed cotton cloth, stouter than chintz but used for very much the same purposes. It is usually unglazed and may be printed on both sides and even with different patterns. Frequently the cretonne has a woven fancy pattern of some kind which is modified by the printed design. It is sometimes made with a weft of cotton waste. CREUSE, a department of central France, comprising the greater portion of the old province of Marche, together with portions of Berry, Bourbonnais, Auvergne, Limousin and Poitou. Area, 2164 sq. m. Pop. (1906) 274,094. It lies on the north-western border of the central plateau and is bounded N. by the departments of Indre and Cher, E. by Allier and Puy-deDôme, S. by Corrèze and W. by Haute-Vienne. The surface is hilly, with a general inclination north-westward in the direction of the valley of the Creuse, sloping from the mountains of Auvergne and Limousin, branches of which project into the south of the department. The chief of these starts from the Plateau de Gentioux, and under the name of the Mountains of Marche extends along the left bank of the Creuse. The highest point is in the forest of Châteauvert (3050 ft.) in the extreme south-east of the department. Rivers, streams and lakes are numerous, but none are navigable; the principal is the Creuse, which rises on the north side of the mass of Mount Odouze on the border of the department of Corrèze, and passes through the department, dividing it into two nearly equal portions, receiving the Petite Creuse from the right, and afterwards flowing on to join the Vienne, The valleys of the head-streams of the Cher and of its tributary the Tardes, which near Evaux passes under a fine viaduct 300 ft. in height, occupy the eastern side; those of the heads of the Vienne and its tributary the Thaurion, and of the Gartempe joining the Creuse, are in the west of the department. The climate is in general cold, moist and variable; the rigorous winter covers the higher cantons with snow; rain is abundant in spring, and storms are frequent in summer, but the autumn is fine. Except in the valleys the soil is poor and infertile, and agriculture is also handicapped by the dearness of labour, due to the annual emigration of from 15,000 to 20,000 of the inhabitants to other parts of France, where they serve as stonemasons, &c. The produce of cereals, chiefly rye, wheat, oats and buckwheat, is not sufficient for home consumption. The chestnut abounds in the north and west; hemp and potatoes are also grown. Cattle-rearing and sheepbreeding are the chief industries of the department, which supplies Poitou and Vendée with draught oxen. Coal is mined to some extent, chiefly in the basin of Ahun. There are thermal springs at Evaux in the east of the department, where remains of Roman baths are preserved. The chief industrial establishments are the manufactories of carpets and hangings and the dyeworks of Aubusson and Felletin. Saw-mills and the manufacture of wooden shoes and hats have some importance. Exports include carpets, coal, live-stock and hats; imports comprise raw materials for the manufactures and food-supplies. The department is served by the Orléans railway company, whose line from Montluçon to Périgueux traverses it from east to west. It is divided into the four arrondissements of Guéret, the capital Aubusson, Bourganeuf, and Boussac, and further into 25 cantons and 266 communes. With Haute-Vienne, Creuse forms the diocese of Limoges, where also is its court of appeal. It forms part of the académie (educational division) of Clermont and of the region of the XII. army corps. The principal towns are Guéret and Aubusson. La Souterraine, Chambon-sur-Voueize and Bénévent-l'Abbaye possess fine churches of the 12th century. At Moutier-d'Ahun there is a church, which has survived from a Benedictine abbey. The nave of the 15th century with a fine portal, and the choir with its carved stalls of the 17th century, are of considerable interest. The small industrial town of Bourganeuf has remains of a priory, including a tower (15th century) in which Zizim, brother of the sultan Bajazet II., is said to have been imprisoned. CREUTZ, GUSTAF FILIP, COUNT (1729-1785), Swedish poet, was born in Finland in 1729. After concluding his studies in Åbo he received a post in the court of chancery at Stockholm in 1751. Here he met Count Gyllenborg, with whom his name is indissolubly connected. They were closely allied with Fru Nordenflycht, and their works were published in common; to their own generation they seemed equal in fame, but posterity has given the palm of genius to Creutz. His greatest work is contained in the 1762 volume, the idyll of Atis och Camilla; the exquisite little pastoral entitled "Daphne" was published at the same time, and Gyllenborg was the first to proclaim the supremacy of his friend. In 1763 Creutz practically closed his poetical career; he went to Spain as ambassador, and after three years to Paris in the same capacity. In 1783 Gustavus III. recalled him and heaped honours upon him, but he died soon after, on the 30th of October 1785. Atis och Camilla was long the most admired poem in the Swedish language; it is written in a spirit of pastoral which is now to some degree faded, but in comparison with most of the other productions of the time it is freshness itself. Creutz introduced a melody and grace into the Swedish tongue which it lacked before, and he has been styled "the last artificer of the language." See Creutz och Gyllenborgs Vitterhetsarbeten (Stockholm, 1795). ! CREUZER, GEORG FRIEDRICH (1771-1858), German philologist and archaeologist, was born on the 10th of March 1771, at Marburg, the son of a bookbinder. Having studied at Marburg and Jena, he for some time lived at Leipzig as a private tutor; but in 1802 he was appointed professor at Marburg, and two years later professor of philology and ancient history at Heidelberg. The latter position he held for nearly forty-five years, with the exception of a short time spent at the university of Leiden, where his health was affected by the Dutch climate. He was one of the principal founders of the Philological Seminary established at Heidelberg in 1807. The Academy of Inscriptions of Paris appointed him one of its members, and from the grandduke of Baden he received the dignity of privy councillor. He died on the 16th of February 1858. Creuzer's first and most famous work was his Symbolik und Mythologie der alten Völker, |