(TILDENS.)

A thoroughly Reliable, Prompt Digestive Ferment. One that does not disappoint where its uses are indicated.

Manufactured Expressly for Physicians' Prescriptions.

Ladispensable in all troubles arising from FAULTY DIGESTION. Especially desirable in CHOLERA INFANTUM and all forms of SUMMER COMPLAINT OF CHILDREN, GASTRITIS AND INTESTINAL DISEASES.

S MPLES AND LITERATURE ON APPLICATION.
PREPARED ONLY BY

THE TILDEN COMPANY,

Manufacturing Chemists,

NEW LEBANON, N. Y.

ST. LOUIS, MO.

WHEELER'S GLYCERITE OF TISSUE PHOSPHATES. WHEELER'S COMPOUND ELIXIR OF PHOSPATES AND CALISAYA.-A Nerve Food and Nutritive Tonic, for the Treatment of Consumption, Bronchitis, Scrofula and all forms of Nervous Debility.

This elegant preparation combines in an agreeable Aromatic Cordial, in the form of a glycerite acceptable to the most Irritable Conditions of the Stomach, Bone-Calcium Phosphate Ca3 2 PO4, Sodium and Phosphate Na2 HPO4, Ferrous Phosphate, Fe3 2 PO4, Trihydrogen Phosphate H3 PO4, and the Active Principles of Calisaya and Wild Cherry.

The special indication of this combination of phosphates in spinal affections, caries, necrosis, ununited fractures, marasmus, poorly developed children, retarded detention, alcohol, opium, tobacco habits, gestation and lactation to promote development, etc., and as a physiological restorative in sexual debility, and all used-up conditions of the nervous system and should receive the careful attention of good therapeutists.

Notable Properties.-As reliable in dyspepsia as quinine in ague. Secures the largest percentage of benefits in consumption and other wasting diseases by determining perfect digestion and assimilation of food. When using cod-liver oil may be taken without repugnance. It renders success possible in treating chronic diseases of women and children, who take it with pleasure for prolonged periods, a factor essential to maintain the good will of the patient. Being a tissue constructive, it is the best general utility preparation for tonic restorative purposes we have, no mischievous effects resulting when exhibited in any possible morbid conditions of the system.

When strychnia is desirable, use the following:

R.

Wheeler's Tissue Phosphates, one bottle; Liquor Strychnia, half fluid-drachm. M. In dyspepsia with constipation, all forms of nerve prostration; and a good pick-me up for daily use in constitutions of low vitality.

DOSE.-For an adult, one tablespoonful three times a day; after eating; from seven to twelve years of age, one dessertspoonful; from two to seven, one teaspoonful. For infants, from five to twenty drops, according to age. Prepared at the chemical laboratory of T. B. WHEELER, M.D., MONTREAL, B. C.

To prevent substitution, it is put up in pound bottles only and sold by all druggists at $1.

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DEERING J. ROBERTS, M.D.,
Editor and Proprietor.

MOSQUITO BITES.-Dr. A. Manquat states that the most successful treatment consists in the local use of formalin, tincture of iodin and alcohol. He uses the pure formalin or alcohol in one half strength. The tincture of iodin is objectionable because of the stain it leaves on the skin.

As a prophylactic against mosquito bites the following combination is of service:

M. Sig. Apply on 'retiring.-Jour. Amer. Med Asso.

THE CONSUMPTIVE'S ROOM.-To purify the air in a room occupied by a phthisical patient use the following:

Acidi carbolici..

Eucalyptol.....

Menthol......

Thymol....

Ol. caryophylli.............

Alcoholis, pure.....................

3 iiss.

.3 iss.

.3 ij..

.3 j.

.....aa 3 ss.

.3 vj.

M. Sig. Spray frequently in the room.-Md. Med. Jour.

M. Sig. A tablespoonful after meals.—Ex,

[350]

Phillips' Phospho-Muriate of Quinine, Comp.

(The Soluble Phosphates, with Muriate of Quinine, Iron and Strychnia.) Permanent-Will not disappoint. PHILLIPS' Only, is Genuine.

THE CHAS. H. PHILLIPS' CHEMICAL CO., NEW YORK.

THE SOUTHERN PRACTITIONER.

AN INDEPENDENT MONTHLY JOURNAL,

DEVOTED TO MEDICINE AND SURGERY.

SUBSCRIPTION PRICE, ONE DOLLAR PER YEAR.

DEERING J. ROBERTS, M.D.,

Vol. XXIV.

Editor and Proprietor.

NASHVILLE, JULY. 1902.

No. 7.

Original Communications.

THE ETIOLOGY AND PATHOLOGY OF MALIGNANT TUMORS.*

BY WILLIAM KRAUSS, M.D., MEMPHIS, TENN.

This subject is entirely too great to be handled successfully in a ten-minute paper, and it will be necessary to confine ourselves to a very few points in the most recent literature, which is becoming daily more voluminous. Unfortunately, investigators in the parasitology and transmissibility of malignant tumors have arrived at some very contradictory results, and their claims are met by the adherents of the autogenetic theory by citing the very facts upon which the parasitologists lean. Andrews has collected 7,881 cases of primary carcinoma, all of which were upon exposed surfacesi. e., subject to infection; but it might be claimed by the irritationists that this is the best evidence of their mechanical (traumatic) origin. Briefly, all the arguments of the one side may be

*Read before the Medical Society of the State of Tennessee, at Memphis,

April 9, 1902.

used by the other-viz., physiologic resistance, heredity, location, trauma, locus minoris resistentiæ, homologous character of cells, etc. Among the most noteworthy recent works of the parasitologists the foremost is the very classic article by Gaylord in the June (1901) number of the American Journal of the Medical Sciences. What has struck the present speaker most forcibly is the apparent harmonizing of the most discordant points of other investigators, as shown by a profusion of most perfect photomicrographs, showing bodies very like some I have photographed from section in stock in my private collection. Gaylord makes the statement that carcinoma is a parasitic disease due to a protozoön which he has found in all cases of cancer examined by his method, and reproduced the same therewith in experiment animals. Hekton, who in a review of the progress of pathology in Progressive Medicine in March, 1902, briefly alludes to all recent observations made in this line, says the whole structure of Gaylord crumbles because he has failed to cultivate the organism artificially and made his inoculation with an unfiltered ascitic fluid which might have contained proliferating epithelia.

I think Hekton's critique too severe, because Gaylord specifically states that he used the sedimented fluid, and his photomicrographs seem to show that the carcinoma in the lung of his guinea pig is derived from the epithelia of the bronchi and air sacs, and is, therefore, homologous to the guinea pig, and not to the man from whom the fluid was taken. This is the strongest refutation of the autogenetic theory, for the favorite peg upon which the autogenetists have hung their arguments is that metastases were of cells homologous to the original site. The bodies (protozoa) were also found in the blood, spleen, and enlarged lymph glands of the experiment animals; and Gaylord is certain that the young forms of his parasite are identical in morphology and tingibility with Plimmer's bodies and Russell's fuchsine bodies, and he further shows that this is only a stage in the development of the parasite, which seems to explain why these were not uniformly present in all carcinomata. Schüller's parasites are said by Gaylord to be identical with his also.

Gaylord is not the discoverer of this protozoon. Virchow long ago called attention to bodies in cancer cells analogous to the protozoa in molluscum contagiosum, the physaliphora. Pfeiffer, in 1888, found protozoa, sporozoa, and microsporidia in a case of carcinosis. One of the strongest arguments made against the etio

A portion of Plate I, more highly magnified; protoplasmic bodies in nuclear area of epithelial layer. The "Plimmer Bodies" are the swelled elements. Next in size are the round cells; then the oval epithelial nuclei. a, Connective tissue round cells. b, One of the three large protoplasmic bodies. c, Epithelial nuclei. d. One of the small free granules.