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Macerating the leaves in water extracts watersoluble coloring matter which, if allowed to remain, would impart to the spirit a brownish-green color instead of the bright green color desired.
is beset with difficulties that can be overcome only by means of considerable practical experimentation and by the use of special apparatus and facilities. For those reasons, therefore, we do not consider its manufacture by the average druggist advisable. A much better article can be obtained at a cheaper price if the manufacture of it is left to concerns equipped to carry out the work.
Such a soap as you require—one that will work in salt water-is ordinarily made from palm oil instead of from the fats enıployed in the manufacture of the usual soft-water soaps. Salts of palmitic acid are not precipitated by salt water.
Headache Remedies. E. R. J. writes: "Can you suggest a formula for a headache powder?"
In a previous issue of the BULLETIN, B. S. Cooban, of Chicago, I11., reports that he has had considerable success in selling a headache powder made according to the following formula: Acetphenetidin
4 drachms. Citrated caffeine.
drachm. Sugar of milk....
6 drachms. Mix and divide into 10-grain powders.
Harrington's Solution and Wright's Solution.
0. D. asks: “Will you please supply me with formulas for (1) Harrington's solution and (2) Wright's solution ?"
1. Harrington's solution may be prepared according to the following formula: Mercuric chloride
.15 grains. Hydrochloric acid C. P.. .22 Auidounces. Distilled water
.1234 fluidounces. Alcohol
.27 fluidounces. 2. A preparation made in accordance with the following formula is sometimes called "Wright's Solution :"
Arsenic trioxide (in powder). 40 grains.
..100 grains. Gold (in leaf).
.13%2 grains. Distilled water, to make.
......one pint. Place the arsenic trioxide and potassium carbonate with four fluidounces of water in a flask, and boil until solution is complete. Weigh out the gold leaf and place in a wide-mouthed bottle, add 12 fluidounces of distilled water, run in the bromine, and then shake until the latter is dissolved, and add the solution previously made and shake for a few seconds. Transfer to a flask or retort, and boil until bromine fumes cease to be given off. Allow to cool, dilute with distilled water to one pint; filter.
Solution of bromide of gold and arsenic, N. F. III, is a somewhat similar preparation.
Mr. Cooban sells two of these powders in an envelope for ten cents.
A combination that is much used in some localities as a headache remedy is the following: Acetanilide
.140 grains. Caffeine
10 grains. Sodium bromide
4 grains. Sodium bicarbonate
36 grains. Mix and divide into 40 powders or capsules.
Here is a headache powder that contains no coal-tar derivatives: Guarana
.10 grains. Sodium bromide.
5 grains. Of course acetanilide and acetphenetidin will have to be mentioned on the label, in accordance with the food and drugs act.
A More Careful Reading Required. L. E. G. writes: "In the formula for spirit of peppermint which appears on page 409 of the U. S. P. IX the use of 500 mils (Cc.) of water is directed. If that amount of water is added to the 800 mils of alcohol and 100 mils of oil of peppermint (contained in the formula) we get a volume of 1400 mils instead of the required 1000 mils. How should the directions read?”
If you will reread-carefully—the directions you will see that the 500 mils of water are not to be added to the alcohol and oil of peppermint. The directions are "Macerate the peppermint leaves, freed as much as possible from stems, during one hour in five hundred mils of water and then strongly express them. Mix eight hundred mils of alcohol with the oil, add the macerated leaves and enough alcohol to make one thousand mils, etc.”
The peppermint leaves are to be macerated only in the water and then expressed; the expressed liquid is, of course, to be rejected.
Recently Honored. At the annual meeting in September Rufus A. Lyman was elected president of the American Conference of Pharmaceutical Faculties. Professor Lyman is dean of the College of Pharmacy, University of Nebraska.
creams,” so-called, are made from bases of starch, casein, stearic acid or various fatty substances, and unless we know the one you employ we cannot supply a satisfactory answer. If you will submit a copy of your formula, we will endeavor to point out a process.
We might say, however, that fatty massage creams made without the use of borax or other saponifying agents will not hold so much water as will those in which an alkali is used. Before the present U. S. P. formula for rose water ointment (containing borax) was adopted the official ointment of rose water (without borax) had considerably less water in its make-up.
grains). Therefore in 100 Cc. of the mixture there would be 154.32 doses, each containing one grain of mercury salicylate. One hundred divided by 154.32 is equivalent to .618 Cc.--the amount of the mixture to be administered at each dose. Expressed in apothecaries' measure, .648 Cc. is equivalent to 10.52 minims (.001 Cc. = .01623 minims).
The Status of Whisky and Brandy. F. R. R. asks: "With whisky and brandy deleted from the new Pharmacopeia, will a druggist have the right to sell either or both of the products for medicinal use?"
The deletion of whisky and brandy is in nowise a prohibitory measure. Whether or not standards for whisky and brandy are included in the United States Pharmacopæia has no bearing on the druggist's right to sell either of the products for medicinal use. If it is permissible under the State laws to sell whisky and brandy when the U. S. P. IX goes into effect, you can still continue to do so. The only significance of the deletion of the two products is that distillers are now relieved of the necessity of supplying medicinal whisky and brandy complying with certain definite standards.
Ginger Brandy. W. & B. ask: "Can you suggest a formula for a so-called 'ginger brandy'?"
The following is a German formula :
Sugar, 200 parts; tincture of orange peel, 20 parts; spirit of nitrous ether, 20 parts. Mix, and add 4500 parts of good whisky or dilute alcohol. Stir in 5500 parts of boiling rain or soft water, adding at the same time 200 parts of ginger, in powder, and 20 parts of powdered galangal root. If desired, add enough burnt sugar to color. Cover the vessel, and let stand a day or two; then filter. By adding the ginger after the water it is possible to avoid dissolving the resinous part of the former, which would otherwise make the preparation turbid.
The galangal may be omitted, if desired, and about a drop of oil of bitter almond added in its place, for every 21/2 gallons of liquor. The oil of bitter almond should be dissolved in the alcohol.
E. R. asks: "Will you publish a formula for a 'skin food' cream?"
The following is a preparation that has been sold under the name of skin food :
A Menthol Ointment.
O. D. asks: “Will you please publish a formula for a menthol ointment?".
.30 grains. Camphor
20 grains. Thymol
10 grains. Boric acid
15 grains. White wax
2 drachms. White petrolatum, enough to make..8 drachms. Triturate the camphor, menthol and thymol together, and then add the white wax and petrolatum, previously melted to. gether. Finally incorporate the boric acid and stir occasionally until the mixture is soiidificd.
.3 avoirdupois ounces. Paraffin
1/2 avoirdupois ounce. Anhydrous wool-fat 14 avoirdupois ounce. Cocoa butter
"A avoirdupois ounce. Liquid petrolatum colorless......8 Auidounces. Borax
's avoirdupois ounce. Distilled water
.4 fluidounces. Oil of rose, synthetic.
..enough. Oil of bitter almond.
.a trace. Color pink with Oil Red “S," which should be dissolved in the melted fats before adding the water containing the borax in solution.
Oil Red "S” is a coloring agent which may be obtained from any of the larger wholesalers, or from dealers in dyes.
A cheaper ointment may be made by substituting hard paraffin for the wax and by cutting down the amounts of camphor and thymol used. The result will be a less satisfactory product, however.
A Question of Dosage. O. D. writes: "A doctor orders a 100-Cc. mixture of liquid petrolatum containing 10 per cent of mercury salicylate. He wishes to administer one grain of mercury salicylate at a dose. How many Cc. or minims of the mixture would he have to use? Please show how you arrive at the result.”
Since the mixture contains 10 per cent of mercury salicylate there is present 10 grammes, or 154.32 grains, of mercury salicylate (1 gramme is equivalent to 15.432
Purity Determination. J. N. K. (Egypt) writes: "Owing to the war it is difficult to obtain drugs and chemicals in a pure state and we are obliged to examine all supplies before daring to use them. Will you please recommend a reliable and practical book stating tests that can be easily applied ?”
A pharmacopæia of the country from which you obtain most of your supplies will probably answer your requirements. If you buy from England, get a British Pharmacopæia; if from France, a copy of the French Codex; if from America, a copy of the United States Pharmacopæia.
DETROIT, MICH., DECEMBER, 1916.
BULLETIN OF PHARMACY
Issued on the first of every month by
E. G. SWIFT, PUBLISHER,
raise in the price of cigars was inevitable; we mentioned the matter two or three times in the BULLETIN
And now that the boost in price has actually been put into effect on a number of popular brands, what is to be done about it?
There would seem to be but three courses open. One is to keep right on in the old rut; another is to subordinate high-priced brands as much as possible; and another is to persuade the manufacturers to reduce the size of the cigar and maintain the old price.
WALKERVILLE, ONT., CAN.
The local association at Chi378 ST. PAUL STREET,
MONTREAL, QUE., CAN.
WHAT THE C.R.D.A. 19 AND 20 GREAT PULTENEY STREET, W., LONDON, ENG.
cago is an extremely wide125 YORK STREET, SYDNEY, N. S. W., AUSTRALIA.
awake organization, and we All articles for publication and all communications bearing on
are, therefore, not at all surprised to learn that the text should be addressed:
it took this matter up some time ago
and went, EDITOR BULLETIN OF PHARMACY,
straight as the crow flies, to what it hoped Box 484, DETROIT, MICH. All business letters should be addressed:
might be a solution. Resolutions were passed PUBLISHER BULLETIN OF PHARMACY,
requesting certain makers to reduce the size Box 484, DETROIT, MICH. and not advance the price. Copies were sent
to the Cigar Manufacturers' Association of THE MONTH'S HISTORY
Tampa, Florida; the Cigar Manufacturers'
chants' Association of the United States; and
question arises in the mind A meeting of the Tobacco Merchants' Asso
of the druggist: Shall I put ciation was held at the association's offices in my selling power behind well-known, adver- New York, eleven prominent manufacturers tised goods that do not net me the profit they attending, and it was unanimously decided not ought to, or shall I run counter to demand and to grant the request of the Chicago druggists. push with all my might special goods, or spe
Such action was not taken through a spirit of cial brands, on which I make a legitimate obstinacy, but for the reason, doubtless, that return?
the makers feared that the "ultimate conTaken as a whole the cigar business is sel- sumer” might not take kindly to the curtaildom satisfactory in the retail drug store. ment of his customary ration. There isn't money enough in well-known Nothing in the way of relief, therefore, brands. Cigars that cost $35 a thousand, or came out of the resolutions passed by the even $32.50, if bought in lots, cannot profitably C. R. D. A., nor is it likely that the situation be sold at six for a quarter; yet six for a quar- can be cleared up in any such manner; but the ter is the prevailing price for 5-cent goods, and request served the purpose of drawing from a it is extremely hard to get away from it. number of manufacturers a statement which
The manufacturers have their troubles, also. may be taken as final. Speaking generally, we Everything is higher, even tobacco leaf, Amer- are not to have smaller cigars at the old price. ican-grown though it is. For a long time An editorial in Tobacco, a journal devoted before it happened, it was predicted that a to the trade, strongly advocates the odd-cent