Advertising Quinine Pills.

The accompanying advertisement of quinine pills is one of Mr. Cooban's latest efforts. It strikes us as being pretty good:

A Pointer

About Quinine Pills

Look out for stale, worthless quinine pills that no more dissolve when you take them than leaden bullets. Compare our pills with others. Test them in any way you please. Notice the results you get from taking ours. Of course there is a reason for it.

B. S. COOBAN & CO.,
PRESCRIPTION DRUGGISTS.

559 W. 63rd Street,
COR. NORMAL Ave.

Printing and Distributing Advertising Slips.

C. J. Griffin, of Montezuma, Iowa, had his local newspaper office set up and print four advertising slips at the same time and on the same sheet. They were of course afterwards cut apart. By this means Mr. Griffin was enabled to get 8,000 slips at what he considers to be the low price of $4.25. Four different kinds of paper were used, and the four slips in different colors were enclosed together in an envelope. The slips advertised respectively a corn cure, a foot-powder, a cleansing cream, and flavoring extract. A sample of the footpowder was also enclosed in the envelope.

Making the Most of a Window Display.

The following newspaper clipping, taken from the Brockville Times of the Province of Ontario, shows how an attractive window display may be made, and indicates also how the druggist may "work" his local newspaper into pushing the good cause along:

AN ATTRACTIVE WINDOW.

A shop window may be a bald and unattractive spot, or it may be a work of art and a liberal education as well. The shrewd and capable merchant realizes this and governs himself accordingly. In these progressive days a great deal of attention is paid to the dressing of shop windows, and Brockville takes pride in the fact that it has several more than usually able window-dressers. These remarks are prompted by the appearance of the window of F. R. Curry, the well known King Street chemist. Mr. Curry always has an attractive window, but the one which caught the eye of the newspaper man was of more than usual interest. It showed specimens of well known drugs in their crude state from all corners of the world. There was opium from Smyrna, in Turkey in Asia Minor, licorice root from Sicily, slippery elm from

Quebec; the curious pitcher-plant from northern Ontario; paraffin from Ohio and Pennsylvania; vanilla beans from France and Mexico; bay leaves from the British West Indies; cubes of rhubarb from Shensi, China; senna pods from India, buchu leaves from South Africa, aloes in gourds from the Barbardoes; alum from Scotland; Castile soap from Spain; olive oil from France; cinchona bark from Equador, in the interior of Central America; and other supplies which chemists keep in stock, all labeled with explanatory notes.

All this makes an interesting and instructive display and is a good example of up-to-date window dressing. That it is good is shown by the number of people who stop to look at it. A little while ago Mr. Curry had a fine sponge exhibit in his window after a similar fashion. Next week it will be a new sort of exhibit.

Novel Newspaper Advertising.—

C. B. Cook & Co., located at West Point, Mississippi, use a good deal of newspaper space, but they use it in a peculiar way. They buy a two-inch strip across the bottom of the page. Type of good size is used, and the message is very short and pointed. Here, for instance, is the text of a recent advertisement of this kind:

Goods delivered never later than twenty minutes after orderedthat's the standard at Cook's Drug Store. Bicycle delivery anywhere in the city. Telephone your wants here. You know they'll receive prompt attention. Cook's Drug Store-Phone 25.

Occasionally, in order to vary the monotony, a similar strip is used up and down through the center of the page. "The idea," explains Mr. Cook in an interesting letter to the BULLETIN, "is to catch the eye of the public with attractive headlines and pointed messages describing briefly the article or the subject we desire to advertise. The buying public never has time to read long and meaningless essays. Our newspaper advertising in a local daily has been thoroughly satisfactory and we have every reason to be pleased with our advertising policy."

PRACTICAL PHARMACY.

The Change in Dosage in the U. S. P.

There is a gratifying amount of comment these days in the pharmaceutical and medical press over the new Pharmacopœia, and it is evident that the work of education is proceeding rapidly. In an article contributed to the October issue of the Brooklyn Medical Journal by Dr. E. H. Bartley is a very suggestive list of the potent tinctures and similar products which have been changed in strength, together with the old and the new doses, thus showing what change in dosage will have to be made. Average doses are of course given, and those for the 1890 products are calculated from those given in the new Eighth Revision:

Popular Products in the U. S. P.—

Much favorable comment has been made on the action of the Revision Committee in giving formulas in the new U. S. P. for a number of the popular mixtures and specialties which have enjoyed so large a sale during the last few years. Dr. Bartley, in the article referred to in the preceding paragraph, gives a list of these mixtures in the new book, although the statement is made by him that a few of them were also to be found in the former revision:

Dilute Hydriodic Acid (Aqueous Solution).
Hamamelis Water.

of the chimney act as the outer sides for the oven, and the wall as the outer back. The drying oven is built in this corner, an air space of 2 inches being allowed between the outer sides and the inner sides. The air space is closed all around.

"The oven is 8 feet high, 32 feet wide, 19 inches deep, and built of wood carefully lined with asbestos and covered with tin. It is divided into two compartments, the upper part being 6 feet high and the lower 2 feet. The parts are separated by a diaphragm or shelf of iron perforated with holes 1⁄2 inch in diameter. The lower part is used for a heat chamber, the upper for shelves. The top of the oven is connected with the chimney flue by a pipe, through which moisture, etc., escapes. The bottom is also connected with the flue by a pipe for carrying off products of combustion, as in this oven it is necessary to use gas, there being no hot water or steam in the building.

"The doors are made like those of a refrigerator, with air spaces. There are two sets of doors above and one set below. The lower doors have holes an inch in diameter bored through the lower part in the shape of a pyramid, to admit air to the heat chamber. The shelves in the upper part are made about 1 inch less in width than the inner depth of the oven, so that with one shelf pushed back and the other pulled forward, the dry air will reach all parts of the closet. These shelves are a framework of white pine strips, 1 inch thick by 2 inches wide, carefully jointed together and covered with unbleached muslin. For ordinary purposes a single spread flame Bunsen burner will supply sufficient heat. And it will rarely be required to be turned on full."

The foregoing, declares Mr. Dunning, is the description of a drying oven rather large for a retail pharmacist, but it should be recognized that one of any size may be built on the same plan. It need not be placed against the wall, but may stand in any desired place. The uses of a drying closet are manifold, and are so well understood by the average druggist that it is hardly necessary to mention any of them.

The Effects of Preserving Milk with Formaldehyde.—

On another page of this issue we are presenting a symposium by three prominent men on the subject of chemical preservatives in foods. It will be noted that Dr. Eccles, one of the contributors, declares that such preservatives are not only harmless, but that they largely prevent disease epidemics. In this connection it will be interesting to note a phenomenon that has been observed during recent years in England, and which negates this theory somewhat.

There have been in London several outbreaks of "epidemic skin disease," the origin of which has been obscure, but which medical practitioners have connected with the milk supply. Dr. Copeman, who made a thorough investigation of a recent outbreak, eliminated practically every probable cause except milk, and discovered ultimately that the milk consumed had been preserved with formaldehyde. No direct proof that the formaldehyde had caused the skin trouble was stated, but Dr. Copeman, in reporting upon the outbreak, wrote the following significant paragraph:

"Formalin, which is a 40-per-cent solution of formaldehyde, is a well-known powerful preservative. But it possesses the disadvantage of retarding, or even preventing

altogether, the pancreatic digestion, and, further, by its tendency to combine with the proteids of milk, is apt to form in that fluid insoluble compounds, thus lowering the digestive value of milk, and perhaps conferring on it irritative properties. In these respects formalin was regarded by the Departmental Committee appointed to inquire into the use of preservatives and coloring-matters in foods as a danger to health, and accordingly that Committee recommended that the use of that substance in the preparation of foods and drinks should be absolutely prohibited."

Syrup of Licorice.—

At the last meeting of the Michigan Pharmaceutical Association Mr. Leonard A. Seltzer, of Detroit, spoke of the difficulties met with in the manufacture of syrup of licorice in accordance with the N. F. formula. After dissolving the mass licorice in the water, an insoluble residue remains, which If cannot be separated by filtration in the ordinary way. attempt at filtration be made, the first portion that passes through is not clear, and as soon as it seems to be coming clear it ceases clarification, the finely divided residue pressing itself against the paper so as to render it almost absolutely impervious. If the operator be willing to omit the filtration and put up with an unsightly preparation he is confronted with the fact that the inert matter immediately starts to ferment and spoils the syrup. To overcome this difficulty Mr. Seltzer uses the following method:

"After disintegrating the mass licorice on a water bath, with the full amount of water which will be required to prepare the syrup, adding from time to time sufficient ammonia water to keep the glycyrrhizin in solution, but carefully avoiding excess so that it may be detected, either by smell or taste, I remove from the water bath and allow to cool. I then add the white of an egg, mix thoroughly, and again heat on a water bath till all the albumen is coagulated. In that way much of the insoluble matter is surrounded by coagulating albumen, but enough still remains to make filtration difficult. The method I use here is this: I take some clean excelsior and place it in the bottom of a percolator, making a surface as uneven as possible. I next beat up some filter paper in a mortar with the solution till it is reduced to a pulp, after which it and the remainder of the solution are transferred to the percolator, returning the filtrate till it passes through clear. The whole solution will then pass through in a reasonable time. The sugar may now be added and dissolved, either in the cold or by the aid of heat. If heat is used it will be necessary to replace, from time to time, the ammonia that is driven off."

A Convenience for the Back Room.—

In a paper presented before the Section on Practical Pharmacy and Dispensing of the American Pharmaceutical Association, Thomas D. McElhenie of Brooklyn remarked that "the storing of the little things around a small, busy shop is quite a problem, and seldom done with any system or with a view to readily finding the thing wanted. After worrying along for a matter of twenty-five years and more, I contrived last summer an arrangement which might easily be copied in any store having a space say 2 feet wide and 7 feet high. The carpenter made for me an upright closet 7% feet high,

outside width 225 inches, inside 20%, depth 6 inches, 15 shelves of 1⁄2-inch stuff, 51⁄2 inches apart in the clear. Procuring about 75 of the winged tin boxes used for 100 mustard leaves, we improved the summer dulness in fitting these boxes, in alphabetical arrangement, for all the small vials of chemical extracts, powdered and soft, essential oils, etc., and the comfort and convenience of the scheme is wonderful. Imagine wanting all at once ammonol, exalgin, mesotan, pepsin, urotropin, xeroform, etc., etc., and finding them all under your hand in five seconds. Any one in reach of my store who is interested is invited to come and see the outfit. I had nearly forgotten to mention the door. It is like a trunk-lid, 3 inches deep, strongly hinged on, and has ten shelves, on which are arranged alphabetically all the fluid extracts that are in 8-ounce vials or less, about 135 of them-another great comfort."

Hot Chocolate for the Fountain.

The Soda Fountain recommends the following formula: Eight ounces chocolate; 4 ounces granulated sugar; 28 ounces boiling water; chocolate syrup enough to make a gallon. Select a rich brand of chocolate. Grate or scrape fine and triturate with the sugar; then in a large warm mortar form a paste by trituration, gradually adding 18 ounces of boiling water; transfer to a porcelain vessel, heat slowly, stirring well; gradually add the remainder of the water, bring to a boil and boil for five or six minutes, stirring constantly; stir for some time after removing from the fire, then bring to a boil again and boil for one minute. By this means separation of cocoa butter is prevented, and the mixture does not require straining, but simple skimming. Add the syrup, and the mixture may be flavored with vanilla extract or other flavors. Care must be exercised to make a smooth paste in the beginning, and to avoid scorching at the last. A quantity of the chocolate may be kept on hand, in a grated or scraped form, mixed with the proper amount of sugar. In serving use 11⁄2 ounces of the syrup, add an ounce of cream, fill the mug with hot water, top with whipped cream, and serve with crackers and a spoon.

Brewing Ginger Wine.

To make 10 gallons of the finest ginger wine, says the Soda Dispenser, boil 12 ounces of bruised best white ginger in 3 gallons of rain-water for fifteen minutes; then add 20 pounds of granulated sugar, the whites of 6 eggs, 2 drachms isinglass, and the rinds of 6 medium-sized lemons, and continue the boiling for thirty minutes longer. During the entire process of boiling the liquid should be skimmed assiduously. Let cool down somewhat, but while still warm strain through a suitable cloth into a clean ten-gallon keg into which has been previously put 20 pounds of chopped raisins. Add the juice of 6 lemons, stir well together, and finally 8 ounces of fresh brewers' yeast. Put the keg in a moderately warm place (70°-80° F.) and let ferment. Fermentation will commence almost immediately, and will be completed in from twelve to fifteen days, according to the warmth of the apartment. The liquid should be stirred from the bottom occasionally during the first few days of fermentation. After the fermentation is over, draw off to a clean container, put in a cool place, bung tightly, and leave for three months before bottling.

Monthly review by OLIVER A. FARWELL.

Lupeol from the Bark of Roucheria Griffittriana Planchon.

This bark has been examined by Sack and Tollens (Berichte), who have extracted lupeol from it in a crystalline condition, the melting point of which is 213°. Its formula is CH2O, and its specific rotation +27°. Glucose was found also. Lupeol is one of the lupinin group of alkaloids that are commonly found in the lupines and allied plants of the pea family. Roucheria belongs to the flax family, and inhabits the Molucca Islands.

Djamboe, or Guava Leaves.

Guava or Djamboe leaves are the leaves of the tropical tree known to science as the Psidium Guajava Lin., from the esculent fruit of which is prepared the well known and delicious guava jelly. It is said that the leaves are used with considerable success in the treatment of tropical diarrhea and cholera. Allan in L'Union Pharmaceutique presents the results of an analysis of these leaves. He found 3.15 per cent of resin, 5.99 per cent of fat, 0.36 per cent of essential oil, 0.39 per cent of chlorophyll, 9.15 per cent of tannin, 3.95 per cent of ash, and 77 per cent of cellulose. The resin melts at 189°, has a saponification value of 131, an iodine value of 115, and an acid value of 89. The specific gravity of the oil is 1.069; it boils at 237°, and has a formula of CHO.. formula of the tannin is CH2O..

Euphorbia Drummondii.

The

In Australia this plant has always had a bad reputation as a stock-poison. Investigations failed to substantiate the charges, but the reputation still lingered. A writer in Garden and Field now states that the only really dangerous part of the plant is the seed, which ripens in March, April, and May. This makes the plant especially dangerous after the autumn rains, when the young grass commences to shoot and necessitates close picking by stock. When feed is long the stock do not reach the plant, which lies flat on the ground.

A New Buchu.

According to the Chemist and Druggist a new variety of buchu leaves has appeared upon the London market. The leaves are round or oval, with entire instead of serrated margins; of a leathery consistence and many oil glands; a quarter of an inch or less in length and sharp-pointed. They make an aromatic, mucilaginous infusion similar to that of Barosma betulina, the official buchu. The ethereal oil is a semi-solid, with a distinct odor like that of peppermint, and contains diosphenol. The botanical identity of the leaves has not been determined.

Ceanothus Velutinus as a Poison.

This plant is frequent along our northwest coast, and is commonly known as "honey dew," "snow brush," or "mountain balm." Dr. R. F. Rooneny, of Auburn, Cal., recently reported to the California State Medical Society a case of skin poisoning very similar to that usually produced by

ered dangerous, he considers it the cause of the repeated attacks, as he could not discover anything more likely to have caused them.

Geneva, Switzerland. The subject will always be a description of a species or family of plants. Members of the society are not permitted to compete, and limitations as to nationality are not made. The essays may be written in Latin, German, French, English, or Italian, and must be transmitted to the president of the society before January 16, 1906."

To Distinguish Between Garden (Pie-plant) and Chinese Rhubarb.

Prof. A. Tschirch, according to Merck's Report, has discovered a way to distinguish the powdered garden rhubarb from the official powdered variety. The former contains a glucoside, rhaponticin (CHO), which is not found in the latter. Ten grammes of the powder is boiled for fifteen minutes in 50 Cc. diluted alcohol and then filtered. The filtrate is evaporated to 10 Cc., and when cold shaken with 10 to 15 Cc. of ether and allowed to stand for several hours, when a crystalline precipitate will appear. On collecting, washing, and drying the crystals will give a purple-red color with sulphuric acid, soon changing into orange. The official powder when treated similarly does not produce a precipitate.

declares it to be a mixture of glycerin, sugar, and a little potash soap. It is recommended for sunburn, freckles, roughness of the skin, etc.

Muiracithin.

A preparation said to contain the active principles of Muira, or Moira puama, a South American plant, asserted to have extraordinary power as an aphrodisiac and tonic. With the active principles is combined ovolecithin, the total phosphoric content being from 7.55 to 7.8 per cent.

Novargan.

Novargan is described as an organic silver compound containing 10 per cent of silver, and occurring as a fine yellow powder soluble in water to the extent of 50 per cent, and affording a reddish-brown solution, but insoluble in ether, benzene, or chloroform. Weak solutions are prepared by sprinkling the powder on the surface of cold water. Strong solutions are prepared by stirring the powder with a little cold water at first to make a thin paste, and then adding the requisite quantity of water. Novargan solutions are not precipitated by alkaline solutions, tissue fluids, blood serum, secretions of the mucous membranes, or hydrochloric acid. The solution has a neutral to weakly alkaline reaction.

Olan.

According to its exploiter, olan is a "vasoliment," but one. not made of oleic acid and Dzonde's spirit. Olan emulsifies with water, and constitutes a more or less stable emulsion, according to the amount of water present (from one-fifth to one-half). These emulsions, being water-soluble, do not injure the clothing.

Piscarol.

A reddish-brown, limpid, syrupy liquid of peculiar odor and taste, soluble in all proportions in water. It is also called "Ichden." Dr. Striebel (Pharmaceutische Post) asserts that "Piscarol" and "Ichden" are identical, chemically and physically, with ammonium sulphichthyolate.

Tachysan.

An embrocation marketed by Paul Hentschel, of Zwonitz, and recommended for the relief of pain. It is seemingly a distillation product of the wood of Cinnamomum camphora and the entire plants of Artemisia cina and Mentha piperata · -practically a mixture of camphor, cina (wormseed) oil, and peppermint oil.

Theranol.

This seems to be identical with and probably a typographical error for Thermiol, put on the market by the Bulling Syndikat, Vienna (National Druggist). It is a solution of sodium phenylpropiolate.

Veratrone.

Name given to a sterilized alcohol-free liquid, obtained from the root of Veratrum viride, and carries .075 per cent of chloretone (National Druggist). It is a clear fluid, having a pleasant odor, and a slightly bitter taste. Four parts of the liquid contain 1 part of the drug. Used as a hypodermic injection. Put on the market by Parke, Davis & Co.