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Why not study French or German when you can do it so easily and pleasantly as the phonograph now makes possible. See adv. on page 13.

One thing that the careful physician will appreciate in the Freligh remedies is that the formula and the dose is given in the advertisement. This is always a good sign; and it is a sign that physicians would do well to demand before using a remedy. We will not say that they should demand that the formula be in the advertisements, but it should at least be supplied on the bottles or packages, or in some other way to physicians before they give the remedy to their patients. The Woodruff Co. takes the plan of giving them right at the start-in the advertisement; and it is a very satisfactory plan for the physician. See adv. on page 3.

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BILLINGSLEY, ALA., September 24, 1901. The last Brace bought of you was for a lady suffering from retroversion of the womb, of which it cured her. She gained 25 pounds in two months. Would that I could enlist more physicians to use your Brace. H. W. THOMPSON, M.D.

Concerning the Natural Body Brace, see adv. on page 4.

The minutely detailed treatment of pneumonia given in Dr. Abbott's advertisement this month will interest all. Dr. Abbott is well known to all of our readers, as the great champion of alkalometry, and what he has to say concerning pneumonia will be found interesting. See page 15.

The Whirling Spray of the Marvel Syringe will appeal to our readers. The Marvel Co. present this syringe as one that will fully extend the folds of the vagina, washing every part thoroughly, and in such a way that it cannot be injurious. The lack of danger is not accomplisht by lack of water, but by the direction and manner in which it is emitted from the syringe. See adv. on page 5.

George F. Roehrig, M.D., Denver, Colo., April 5, 1898: "Pabst Malt Extract is by no means new to me. I have used it for years, in such cases of general debility and denutrition, where a reconstructiv agent was indicated, and invariably with success.'

Need a new set of harness, Doctor? Well, if not just now, you may soon, and so you would better send now for the King Harness Co.'s catalog. See adv. page 19.

The following is reported to us: "In a case of typhoid fever where the patient could not tolerate a single ounce of milk, Trophonine was used with markt success. Practically no tympanites developt during the course of the disease. I regarded the extreme distaste for milk as a calamity, and was forced to use Trophonine exclusivly, but after it had demonstrated its value the "calamity" turned out to be a blessing. I have used many kinds of artificial and natural foods, but none of them have, in my experience, given the markt success of Trophonine.' Trophonine is made

by Reed & Carnrick, Jersey City, N. J.
(Continued over next page.)

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farming

$3000 business, slight opposition, rich country, plenty of work, 98 per cent. gocd

pay. No better country, location. W. A. Webster, N. 4th St., Zanesville, Ohio. unopposed practise, 95 per cent. collectible,

$2500 given to purchaser of my nine-room residence

and office; price, with thorough introduction, $1,200. Part cash, balance on time. Address Dr. E. D. Moore, Moorefield, Ohio. OR SALE-Practise paying over $1,600 per year and property costing $1 650, for $1,450. Town of 400. Northwestern Ohio; rich farming community; pike roads; no hills; railroad; easy terms. Address "K," care of MEDICAL WORLD.

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FOR SALE Eight-room house, barn, big lot, and $2.500 unop

posed practise, for $450. Will give time on part. Big snap. F. Yonkers, M. D., Woodville, Michigan.

Aylvania, Ohio or New Jersey preferred. Will buy stock of ANTED location for drug store and medical practise, Penndrugs, etc., if location suits. Give price and describe fully. Address "Doctor," Quakake, Pa.

FOR

OR SALE-Unopposed village practise of $2,000 yearly. About 40 acres of land, good house, rffice, stable, etc., at a bargain. Address, with stamp, "Dr. M.," R. F. D. 6, Columbus, Indiana.

FOR SALE Physician's residence, small drug store and buide ing, in town of 450; in best part of central Illinois. Splendid chance for good man. Good reasons for selling. Address Dr. E. N. Wheeler, Latham, Ill.

FOR SALE-Good location; practise $2,000; prominent corner

lot; house, office and barn, $2,600. Pop. 1,300. Central Ohio. Particulars by mail. Reason, ill-health. Address "G," care of MEDICAL WORLD.

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WORLD.

C

ENTRAL OKLAHOMA-$3,000 practise. Insurance and railroad appointments. Best outfit in Territory; growing town of 1,000; collections, 95 percent. Bargain fine opening, any school. Moving to city. "Oklahoma," care of MEDICAL WORLD. ANTED-Location or partnership June 15. First class. Indiana preferred. No property. Dr. H. A. Giltner, Lexington, Ind. Buys $1,800 practise; six-room house; two acres tions good. Bargain. Address, Box 94 Hutto, Texas.

WA $1300 Town 600; black prairie land. Collec

CAN SELL YOUR MEDICAL PRACTISE (with or without real estate), no matter where i is or what it is worth. Send full particulars, including your best cash price, and learn how. If you want to buy a practise anywhere, state your requirements. W. M. Ostrander, 310 North American Bldg., Philadelphia. ANY regular, energetic practician can learn of a first-class

location for moderate price by addressing A. B. C., General Delivery, Canton, O.

FOR SALE, Paldstand. Will sell drugs, instruments, etc.,

OR SALE-Allopathic physician's practise (about $2,500) in

at invoice (about $700), convey three years' lease and introduce successor. Address H., 7302 Race St., Pittsburg, Pa.

FOR

OR SALE $1,500 practise in good country town for price of property. New England. Address B. C. L., care of MEDICAL

WORLD.

WA

ANTED-To buy property and practise in nice laying section of Ohio (within fifty miles of large city preferred), in town of not less than 500. Good roads, telephones, railroad. Live, established, regular practise, not less than $2,000 yearly. Address Dr. L. S. Hennen, Rcsbys Rock, W. Va.

Good practise given to purchaser of my property in central

Pennsylvania. For description and particulars, address Box 304, Hughesville, Pa. OR SALE-A snap. First-class location in town of 500, in Anderson county, for price of doctor's residence. Price, $800. Address Dr. Bradford, Overbrook, Kas.

FOR

Fo

OR SALE-On account of other busir ess interests, I offer for sale my large practise and beautiful home in a south Misscuri county seat of 3,400 inhabitants. Fine prairie country, well settled by eastern and northern people. Lovely climate. A snap for a good man with some money. Address "M," care of MEDICAL WORLD.

FOR SALE $250; horse, carriage, harness, cffice furniture, drugs. Large territory. Address S, care Ralph M. Mcrrill, M.D. Lincoln, Neb.

$2000 practise free to purchaser of my ten-room brick

house; five lots. Southeast Nebraska. Price, $2,000. "L," care of MEDICAL WORLD.

INVESTIGATE this drugs, fumiture and $1,200 unopposed practise in western Illinois for $200. Will introduce purchaser. Address Illinois, care of Medical World.

Circulation: March, 1904, 35,419.

THE MEDICAL WORLD

The knowledge that a man can use is the only real knowledge; the only knowledge that has life and growth in it and converts itself into practical power. The rest hangs like

dust about the brain, or dries like raindrops off the stones.-FROUDE.

The Medical World

C. F. TAYLOR, M.D., Editor and Publisher

A. L. RUSSELL, M.D., Assistant Editor

SUBSCRIPTION RATES: To any part of the United States, Canada, and Mexico, ONE DOLLAR per year, or FOUR YEARS for THREE DOLLARS; to England and the British Colonies, FIVE SHILLINGS SIX PENCE per year; to other foreign countries in the Postal Union, the equivalent of 5s. 6d. Postage free. Single copies, TEN CENTS. These rates are due in advance.

HOW TO REMIT: For their own protection we advise that our patrons remit in a safe way, such as by postal money order, express order, check, draft, or registered mail. Currency sent by ordinary mail usually reaches its destination safely, but money so sent must be at the risk of the sender.

We cannot always supply back numbers. Should a number fail to reach a subscriber, we will supply another, if notified before the end of the month.

Notify us promptly of any change of address, mentioning both old and new addresses.

If you want your subscription stopt at expiration of the time paid for, kindly notify us, as in the absence of such notice we will understand that it is the subscriber's pleasure that the subscription be continued, and we will act accordingly. Pay no money to agents unless publisher's receipt is given.

ADDRESS ALL COMMUNICATIONS TO

"THE MEDICAL WORLD"

1520 Chestnut Street

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Philadelphia, Pa.

No. 4

Language is a growth rather than a creation. The growth of our vocabulary is seen in the vast increase in the size of our dictionaries during the past century. This growth is not only in amount, but among other elements of growth the written forms of words are becoming simpler and more uniform. For example, compare Eng. lish spelling of a centnry or two centuries ago with that of to-day! It is our duty to encourage and advance the movement toward simple, uniformn and rational spelling. See the recommendations of the Philological Society of London, and of the American Philo logical Association, and list of amended spellings, publisht in the Century Dictionary (following the letter z) and also in the Standard Dictionary, Webster's Dictionary, and other authoritativ works on language. The tendency is to drop silent letters in some of the most flagrant instances, as ugh from though, etc., change ed to t in most places where so pronounced (where it does not affect the preceding sound), etc.

The National Educational Association, consisting of ten thousand teachers, recommends the following:

"At a meeting of the Board of Directors of the National Educational Association held in Washington, D. C., July 7, 1898, the action of the Department of Superintendence was approved, and the list of words with simplified spelling adopted for use in all publications of the National Educational Association as follows:

tho (though);

altho (although);

thoro (thorough):

thorofare (thoroughfare);

thru (through);

thruout (throughout);

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"You are invited to extend notice of this action and to join in

securing the general adoption of the suggested amendments →→→ IRVING SHEPARD, Secretary."

We feel it a duty to recognize the above tendency, and to adopt it in a reasonable degree. We are also disposed to add enuf (enough) to the above list, and to conservativly adopt the following rule recommended by the American Philological Association: Drop final "e" in such words as "definite," "infinite,' "favorite," etc., when the preceding vowel is short. Thus, spell opposit, ""preterit," "hypocrit," "requisit," etc. When the preceding vowel is long, as in "polite," finite,"

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unite," etc., retain present forms unchanged. We simply wish to do our duty in aiding to simplify and ration alize our universal instrument-language.

"Buy September Wheat."

Are doctors such inveterate speculators? If not, why do so many circulars and circular letters continue to come to me, and presumably to all other doctors? I thought I had the speculation fever about killed out among the doctors. I certainly stopt a great deal of it; but after being whipt out, its policy is to "bob up serenely" after lying quiet for awhile, as tho nothing had happened. Here comes a communication from a Chicago firm headed "Speculation in Farm Products now Popular." "Buy September Wheat." Do they think that if a Philadelphia doctor wanted to speculate he would send all the way to Chicago to do it? I have received such communications from St. Louis, also, and I suppose the whole list of doctors in Philadelphia got the same. Does this indicate that doctors do such ridiculous things as to send their money half way across the continent for a firm of entire strangers to speculate with? If they do, do they ever expect to see their money again? I was talking the other night with a fire insurance man of large and wide experience, who comes into contact largely with the drug trade and to some extent with doctors. He said that doctors are all right in their own profession, but outside of it, particularly in business, "they don't know a thing." I referred to the ease with which they can be induced to invest in visionary schemes. "Yes," he said, "one can sell them a gold brick any time if they happen to have the money.'

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But going back to wheat: I have a very dear friend (not a doctor) who had saved a pretty snug little sum by some years of industry and thrift. A time came when all his accumulations were in cash; and then the tempter

came.

How easy to put a large part of his money into wheat margins and see it grow from day to day. He did it, and it grew, and he was elated. How easy! How different from hum drum toil from morning till night as a retail merchant. He continued. His gains were wiped out. Then his principal was endangered. It, at least, must be saved. Some of the reserve must be brought forward for that purpose. But why make the story longer? His snug little fortune was all swallowed up in the whirlpool of the pit. One who had always been sensible, conservativ and thrifty was ruined in a few short weeks or months. He had to begin again at the bottom of the ladder, under much more trying conditions than the first time, and now after a second period of years of struggle, he has his head just above the waves. Think of this when a broker says to you, "Buy September wheat."

Analgesics at a Reasonable Price.

Please see the article entitled "How a Village Doctor Saves $45 Per Year on One Preparation," and our comments on same in March WORLD, pages 102 and 103. Continuing the effort to serve the daily interests of the average doctor, and knowing that many would put off from time to time the making up of a preparation like this in quantity (many would be too busy and others would procrastinate), and also knowing that many like tablets for convenience in dispensing, and that still others write prescriptions instead of dispensing, and that they would rather prescribe preparations of definitly known composition at a moderate price instead of a preparation of secret composition (tho knowing that acetanilid is the chief constituent) under a fanciful name at a fancy price,we sent the following letter to our leading pharmaceutical houses:

Gentlemen-We have been publishing the well known fact that for years the physicians of this country and their patients have been paying an extravagant price for acetanilid mixtures under fanciful names, antikamnia, for example, and for combinations of such mixtures with quinin, salol, codein, heroin, etc,, chiefly in tablet form for convenience in dispensing. We wish to know, in order to inform the profession, what you, as legitimate manufacturing pharmacists, have done to meet the wants of the profession for a safe acetanilid mixture, at a reasonable price. Also, we wish to know what (if any) combinations of the same with quinin and other drugs in daily use you make in tablet or pill form for convenience in dispensing. Please give price of each to physicians, in ounce lots, for comparison with the prices of the proprietary mixtures with fanciful names. Physicians should have this information, and we propose to give it to them. Please give full information, and prices, for publication. Very truly, THE MEDICAL WORLD.

We found to our gratification, upon receiving the price lists from the various firms, that this want is very well supplied, and that there is no excuse for physicians paying, or forcing their patrons to pay, the fancy prices charged

by the vendors of proprietaries under fanciful names. That sterling firm, Wm. R. Warner & Co., of this city, sent an exceedingly nice letter in reply, but markt it strictly not for publication in this connection, as they "have no antagonisms in connection with manufacturers," and refer us to pages 58, 69, 76, and 178 in their catalog. They further explain that the prices there given are not intended for publication ordinarily, because they are expected to protect the drug trade. They further add, "However, we would be willing to sell to the profession any of the articles indicated at the prices shown in the book, but would rather prefer not to be taken up too prominently in connection with any controversy that might arise." This position is fair, and the spirit admirable. We turned to the pages indicated, and there found a great variety of acetanilid preparations in tablet form, from simple acetanilid in tablets of from I to 5 grains, to many different formulas of compound acetanilid tablets, tablets either plain or chocolate coated, and the prices are exceedingly reasonable. We hesitate to mention the prices here on account of not wishing to embarrass the firm in any way, but we suggest that you could not do better than to write for their catalog (Messrs. Wm. R. Warner & Co., 639 N. Broad street, Philadelphia), and after you get it indicate to your druggist what you wish him to carry in stock for your prescriptions, or send an order direct if you are in the habit of supplying medicins directly to your patients-country doctors cannot avoid doing some of this.

The following excellent reply came from Messrs. H. K. Mulford Company, of this city. Dr. C. F. Taylor, Editor MEDICAL WORLD.

Dear Doctor-In reply to your letter of the 3rd inst., we have pleasure in forwarding you, under separate cover, one of our catalogs. You will note that we list Acetanilid, together with following combinations:

Acetanilid Comp. No. 1, the formula usually employed for relieving migrain, contains:

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The Upjohn Company, of Kalamazoo, Mich., answer as follows:

C. F. Taylor, M.D., Philadelphia, Pa.

Dear Doctor:-Replying to your favor of the 3rd inst., will say that we do not manufacture any combinations which we put out as substitutes for the proprietary preparations, altho we fully realize that many of them are sold at an extravagant price. We do, however, manufacture several combinations in pill and tablet form which contain the ingredients you mention.

We are inclosing you one of our price lists in which we list several different acetanilid combinations, some in the form of pills, some in uncoated tablets, and some in chocolate coated tablets. Our list prices are subject to a discount of 25 percent, and we make special net prices on bulk quantities of 5,000 or more. You will note that we have checkt the list and would refer you to the following pages: 7, 26, 55, 56, 59, 84, 96, 103, 105, 117. Very truly yours,

THE UPJOHN COMPANY.

We note that the tablets are cheaper than the pills of similar composition. There is a wide selection of acetanilid tablets, both simple and compound, the latter embracing many useful combinations at reasonable prices. Messrs. Parke, Davis & Co., of Detroit, Henry K. Wampole & Co., and John Wyeth & Bro., of Philadelphia, reply by referring us to their catalogs, which they send, and in all of which we find an ample variety of acetanilid tablets both simple in 1 to 5 grains, and compound tablets showing many excellent combinations, at reasonable prices.

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Do you here find food for thought? THE MEDICAL WORLD is publisht in the interest of the medical profession. The medical profession is learning the value of THE WORLD, for subscriptions have been pouring in during the last two years as never before. And we are learning better and better how to serve the interests of the profession, and the increast patronage by the profession gives us more courage than ever before. Let THE MEDICAL WORLD and the medical profession join hands closer than ever before to help each other, and to find evils and crush them.

So much for acetanilid (and combinations of acetanilid with other drugs) as an analgesic, or pain reliever. As is well known, acetanilid is a heart depressant, and the drugs combined

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About twenty years ago a wonderful coal tar synthetic chemical was announced that would reduce temperature like magic. On account of this quality it was called antipyrin, and it was patented under that name. We thought that we had found the thing with which we could control fever with definit certainty, which would give us an undreamed-of power over disease. The medical press was filled with praises of this wonderful drug. But while it cooled the fever patient, many of them got cold-and are cold yet-in their graves. The alarm was sounded, and a rapid retreat was made. It would not do to subject the fever patient to such a risk. The heart depression was too great.

Antipyrin was soon followed by other coal tar derivativs, but now their power to relieve pain was brought into prominence, and they became known as analgesics rather than antipyretics, tho they are both. Their use in fevers were so condemned on account of the danger of heart depression in connection with the non-resistance occasioned by prolonged or severe illness, that their use as antipyretics was lost sight of; but they could be given with apparent impunity for headache, neuralgia, painful menstruation, etc.,-conditions of a temporary nature and in which the heart resistance had not been reduced. So you see the changed application, and the reasons therefor. So now drugs of this class are known as analgesics.

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Acetanilid and phenacetin became, and still are, the most popular of this class. By some good fortune, acetanilid did not become patented, and so we have always had it at a very low price. For a while it had no special friends, because it was to nobody's special financial advantage to push it; while phenacetin was vigorously pusht for the great profit in it, and for awhile "antifebrine," which was only a copyrighted name for acetanilid, was pusht at about the same price as phenacetin, until the fact just stated was found out. Then arose "antikamnia-opposed to pain." By dint of very skilful advertising and liberal samples, this mixture of acetanilid with some bicarbonate of soda to increase its solubility, and perhaps some caffein to counteract the depressing tendency of the acetanilid, got a start. Knowing ones were surprised at this, for it was supposed that every one knew that it was a mere

mechanical mixture and not a definit, distinct and individual chemical, and if doctors wanted an acetanilid mixture, why not make it, at onetenth the cost? But antikamnia was persistently and very skilfully advertised, and to the great surprise of many, it continued to prosper. Perhaps one reason was its preparation in tablets convenient for dispensing. So in spite of the vast difference in price of about 30 cents a pound for acetanilid and $1.00 per ounce for antikamnia, the latter still prospered, mainly thru the medical profession-and perhaps there are some doctors still so in the dark as to pay, or have their patients pay, the extravagant price for antikamnia, when acetanilid is so cheap, and when it is now put up in tablets of various sizes, and numerous combinations of it with other drugs are put up into tablets, by our leading pharmaceutical manufacturing houses, at right prices.

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But we are wandering from our subject. We started to consider phenacetin and acetanilid, the two drugs that have been the leaders of the antipyretic-analgesic group. (Antikamnia, and the numerous imitations of antikamnia, caused to come into existence doubtless by the surprising commercial success of antikamnia, are only acetanilid mixtures.) I intended to try to present the rather complex chemistry of these chemicals so simply that any reader could easily understand; but it is a difficult task, and perhaps many readers will thank me for quot. ing from Bartley's Medical Chemistry, page 460, simply this statement; speaking of phenacetin it says: "This compound is closely related to acetanilid." We know that they are closely related therapeutically. Phenacetin has been very popular. At $1 an ounce its manufacturers could afford to make it so, and foster the claim that it is less depressing than acetanilid. Many doctors believe this to be true; many don't. I cannot say. My observation has been limited, as I am not in practise (tho the rest of the staff is--and our numerous contributors), my specialty being medical journalism. No one man can be a successful editor and publisher and at the same time conduct a practise as it should be conducted. My observation is that these two drugs are about equally depressing. I have always counseled against the use of these depressing and blood destroying drugs; but there are painful conditions which with most people require a pain reliever, and these drugs are usually not as objectionable as opiates. I usually prefer pain to drugs when I must choose between the two evils; hence I have never taken but a single dose-a small one at that—of any of this class of drugs, and I have forgotten what one it was, but I think it was a sample tablet of one of the numerous imita

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As those who remember my editorials in the last several years know, I have been opposed to phenacetin because of the following: It is made in Germany and imported from there into this. and other countries, and the price charged to consumers in this country is about three times that charged to consumers in other countries. For example, it is $1 per ounce here, while just over the line into Canada it can be bought for about 35 cents an ounce. And the difference is not in the tariff; our tariff would make a little difference, but very little. Our patent they do it. It is to this injustice that I have laws permit them to thus impose on us, and vigorously objected. The patent will run out in a few years, and then the price will take a delightful tumble.

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In this connection I have been interested in the appearance of an American chemical of this class, an improvement upon all its forerunners in that it is claimed that it is positivly not depressing to the heart. It is called thermol, because of its effect on the temperature, and it is boldly recommended as an antipyretic in such serious diseases as pneumonia, typhoid fever, etc., as well as an analgesic in headaches, neuralgias, menstrual pains, etc. Today I called on the inventor, Dr. S. Lewis Summers, to get some final points before writing this, particularly as to its chemistry, and I finally got him to state the chemistry of the group so simply that I will present it here:

Acetanilid acetic acid plus aniline.
Phenacetin phenetidin (a chemically com-
plex substance in the form of a brownish,
oily liquid, the chemistry of which I will
not attempt here) plus acetic acid.
Thermol phenetidin plus acetic acid plus
salicylic acid.

These are not mechanical mixtures, as antikamnia is a simple mechanical mixture of its constituents in a mortar, but the constituents are put into special apparatus in definit quantities, and subjected to great heat and pressure for a long time. The result is a chemical union-the creation of a new and distinct chemical product, which is then washt of any accidental uncombined excess, and then tested and prepared for the market.

I askt Dr. Summers why the addition of the salicylic element should prevent depression. He referred to clinical experience, with the

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