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of Savannah, Ga. I will also state that the mortality statistics of the two schools compared show largely in favor of homœopathy.

For allopathy the average of deaths was from 25 to 30 per cent. For homeopathy the average was only .06 per cent. This needs no comment.

At Chattanooga, Tenn, Dr. D. P. Curtis has lately received an appointment upon the Board of Health. From this narration of facts we learn that homoopathy is not only progressing, but, at the same time, reconstructing its educational basis. By which, in the advance and increase of converts to our system, we will be enabled to keep abreast with the world of medical science; not only abreast, but it shall be that allopathy will be left as far behind in surgery, pathology, etc., as it is in therapeutics, and it shall take the place now occupied by the followers of Thomson.

When the National Board of Health was organized, the President honored homœopathy by appointing our worthy colleague, T. S. Verdi, M. D., as one of its members. The bulletin issued by this board has been sent to the Secretary of the State Homœopathic Medical Society since its first issue; thus virtually the State The prevalent idea among the laity is that the two Society is recognized by the National Board of Health. schools will finally merge into one; but that is imposThe following examples of the advance of homœo-sible, as I hope I have demonstrated, of homeopathy pathy I have collected from various medical journals: and allopathy per se. That there will be but one sysIn Sacramento, Cal, the large county hospital, wirich tem of medicine at some time in the future I think constantly maintains from 130 to 150 patients, the city there is no doubt; and it will result by an amalgamaand county dispensary and jails, and the large Protest- tion, not of principles, but by the consenting of allo ant orphan asylum are all exclusively under homoeopathy to the adoption of our law. pathic control. Also the city board of health. The office of commissioners of the insane has also been promised them. "This is as grand and important a victory for homeopathy as was ever won in this country, and all done in two weeks, previous to which time it was not thought of."

The question is often asked: How will the different medical sects be amalgamated? The following answer is to be found in the Investigator for Sept. 15, 1879, and explains this indefinite question of amalgamation:

Very easy; the leaders in the eclectic and alloIn Blackwoodtown, N. J., an asylum for insane pau-pathic ranks are fast paving the way. pers, a few months ago, was placed under superin- Small doses have been adopted by the mass of tendance of homœopathy. physicians.

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In New Hampshire a homoeopathic physician has There is a hungering for something beside 'shotbeen appointed surgeon general, with the rank of brig-gun' practice. What weapon shall be selected, and adier general. what is the rule of selection, is the anxious longing. Some of these leaders begin to see that there is a method that will secure direct action' Their vision has not grown wide enough to see a law,' but they can not glean long in our literature before the fact will dawn upon them. Then they will try it (as many are quietly now doing), and then it will be broached here and there, quietly at first; then the echo will swell the chorus: Homeop thy, the science of therapeutics, excelsior!' Then we will all shake hands, and turn our attention to studying therapeutics, materia medica, posology. Then we expect to see the union of many societies, the closing of some colleges, the suspension of several journals, and the closure of many drug stores and pharmacies. Such a revolution will not occur without opposition from the small men in all schools. But it will come. 'Truth is mighty and shall prevail.' The distinctive terms, Allopathic, Homœopathic, and Eclectic, will drop out of our vocabulary; the first, Contraria,' will guide in hygiene; the second, Similia,' in therapeutics; and the last will indicate the royal freedom of medical study."

A homoeopathic physician was re-elected this spring mayor of Warrensburg Mo., and was also appointed Examining Surgeon for the U. S. Pension Department or District. In this same State great improvement has been made in the standard of the medical school, it being now 5.7 per cent. harder to graduate than it was last year. Just at this point I will mention the following progressive stride made by the Homœopathic Inter-collegiate Congress of the United States, which met at Indianapolis, Ind., April 30th, 1879. Delegates from five different medical colleges were present. One main object of the congress is to improve the standard of medical education. They unanimously agreed that the time of study required of candidates for graduation shall have been three full years, including three courses of lectures in a reput ble medic 1 college. "Do you find such an action as that taken by any of the allopathic colleges? On the contrary, know they hold the idea that two ye rs is sufficient for any ordinarily educated man to study medicine before graduating Either homœopathy is a much more profound study than allopathy, or our standard of education is much higher, Allopathy is welcome to either horn of the dilemma.

In Pittsfield, Pike Co., Ill., at the recent election of county physicin, homœopathy was successful over both eclectic and allopathic competitors.

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Dr. Thos. J. Mays (N. Y. Med. Jour., Oct., 1879) explains, with cut, the use of a very simple steam In Joliet, Ill., a homeopathic physician has been ap-jacket devised by him, and claimed to be of service pointed prison physician of the Northern Illinois Peni- in cases where external heat is desirable. tentiary; Dr. R. Ludlam has been reappointed on the I'lino s Board of Health by the Governor; Charles W. Lorg, M. D., has been appointed U.S. Examining Surgeon of Pontiac, Ill.; the homoeopathists of Chicago have petitioned the commi sioners for recognition by largest attendance, 200. suitable appointments upon the Melical Board of County Hospitals. We all sincerely hope their efforts may meet with due success.

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N. Y. OPTHALMIC HOSPITAL.-Month ending November 30, '79: Prescriptions, 3,272; new patients, 360; resident patients, 44; average daily attendance, 142;

J. H. BUFFUM, M. D., Resident Physician.

At C dar Rapids, Iowa, homeopathy has just received its first official recognition by the appointment of Dr. HORLICK'S FOOD has become so well and favorably C. E. Cogswell, upon the Board of Health. L. S. Ord-known to the profession as an adjunct in the nutriway, M. D., has been elected m mber of the Board of Health at Hot Springs, Ark. Prof. Danforth has the honor to have performed the first successful case of ovariotomy at Milwaukee, Wis. We learn that 18 months are required at Ward's Island Hospital, instead | of a year, as formerly.

tion of children, that it is scarcely necessary, for us to call attention to it. To those who have never employed it, we need only say that you will find it a food perfectly free from starch, and one which will upon many occasions serve you excellently in cases of mal-assimilation in adults as well as in children.

A FUNGOD GROWTH-THE CAUSE OF

WHOOPING COUCH.

(TUSSIO CONVULSIVA, PERTUSSIS.)

BY HENRY A. MOTT, PH. D., E. M. The idea has prevailed, and in fact is prevalent now to a very great extent, that whooping cough must run its course or that it has a definite limit, and if the cough is broken up, it would be much worse for the child; for it would be laying the foundation of some fearful disease in the child's system. To this conclusion. I fully believe can be attributed much of the mortality among children. The deaths from whoop ing cough, according to Condie, are 1 to 82 of the entire mortality in Boston, 1 to 46 in Charlestou, 1 to 95 in Baltimore, 1 to 63 in Philadelphia, and 1 to 64 in New York. When we consider such figures as these, surely any effort made to discover the cause of this

"That the essential symptoms of whooping cough are the result of a spasmodic closure of the glottis, there can be but little doubt; but whether this is owing to an irritation seated in the larynx or trachea, or in the brain, it is difficult to determine." In pathology as uncertain as this, how are the proper remedies to be selected? Are they to be addressed to the brain, the origin of the nerves, or the larynx or the trachea? The question having only recently been answered, among the former remedies are found purgatives, astringents, emetics, expectorants, narcotics, vesicants, tonics, depletants, anti-spasmodics, caustics, revul sants, anti-periodics, ablutions, etc. As Dr. J. O. Hamilton, in his able article* on whooping coughs, re marks: "How can we imagine such a hydra-headed disease requiring such fearful instruments for its decap itation?"

From the above it is certain that Dr. R. Dungleson, in his work on Diseases of Children, stated the truth when he said, "But little is known of the cause of whooping cough

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The above illustration is of the fungus spores and mycelium. Of course no one slide gave the field here represented, but it is the result of the examination of a very large number. A represents the mycelium; B, cells thrown off from the epithelium; C, the fungus spores which exist in great numbers, D représent a film of epithelium from the under surface of the epiglottis.

terrible disease, and to point out the proper line of As stated before, in 1871, Dr. Ludwig Letzerich comtreatment, should be met with a hearty reception. menced a series of microscopical investigations as to Much diversity of opinion has existed in regard to the real cause of whooping cough, and his original inves the pathology of whooping cough. Fortunately, how-tigations are to be found in full in Virchow Archiv. Letz ever, owing to the investigation of Dr. Letzerich, of Germany, in 1871, and the confirmation of his results by myself, our knowledge of this disease has been greatly enhanced. Condie says: A majority of the most authoritative writers refer it to bronchial inflammation, which by few is considered to be of a specific character. By some, however, who have written very ably upon the disease, the bronchial affection is viewed as a mere concomitant, or effect of the whooping cough, and not in any degree essential to its existence."

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Most of the writers refer it either to disease of the pneumogastric or phrenic nerve, or to disease of the brain, affecting the origin of the respiratory nerves, while others consider the cerebral irritation to be secondary to the bronchial disease, and often absent.

erich showed for the first time that if the expectorated mucus whooped up during the short duration of the first catarrhal-like stage of the disease, be examined under the microscope,there will be seen,besides the portion of phlegm, etc., etc., small elliptically-shaped, brownish-red fungus spores, some of which have par tially germinated and brought into existence mycelium. This discovery gave a clue at once to the cause of pertussis, and opened a new channel for its treatment. As the editor of the Quarterly Journal of Microscopy stated that this observation of Letzerich had not as yet been confirmed by any other investigator, having an opportunity offered to study the disease in my own

* Page 299. O. Vol. 49, p. 530.

+ Ills. State Med. Soc. Rep., p. 48. 1875.

children, I concluded to do so; and after a careful microscopical investigation of the phlegm whooped up at various stages in the development of the disease, can now state that in the main my investigations confirm those of Letzerich; the only difference being that he found the developed fungus brownish-red, and these I was unable to detect.

The ripe spores of whooping cough differ from those of diphtheria in not being circular, and in not showing any finger-like protuberances.

The growth of the mycelium in the masses of phlegm goes on very rapidly, and the threads acquire consid erable length, especially when the disease is at its height. The expectorated mucus is also very thick at this stage, and on drying becomes of a glassy appear ance, although quite tenacious. In these latter stages the mycelium are very plentiful, and there is an energetic formation of spores.

It the fresh spores are treated with iodine and concentrated sulphuric acid, the mycelium are colored beautifully blue, and the unripe spores, which are white, now appear brown.

To show how this theory was received by Dr. Hamilton, who made such a careful investigation of all other theories, I will quote what he says: "The only theory that seems to me tenable, and I think the success of certain remedies bears it out, is that whooping cough is the direct result of a fungus growth; that the spores are thrown off by the individual coughing, and are received by another in the saliva of the mouth which retains them until they have time to attach themselves to the under side of the tongue, where the mucous membrane is the thinnest and softest of any part of the mouth, and at the same time are not so liable to be dislodged by drink or food. In this situation they remain until they are able to germinate and spread along the sides of the tongue and backward, until they reach the larynx and pharynx, when the full whoop is established. Elevations or lumps can very plainly be seen under the tongue before the pa tient begins the whooping, but the catarrhal symptoms are at this time quite prominent. Discharge from the nose, suffused eyes, headache, some fever and general lassitude. The time of incubation is from nine to fif teen days, though varying in the different subjects. These elevations on either side of the frænum linguæ are small, and might escape observation unless carefully sought for, as it is quite difficult to induce the young subject to turn the point of the tongue up long enough to make the proper observation."

Letzerich made numerous experiments on rabbits with the spores from whooping cough. The spores were cultivated on pieces of bread soaked in milk and then introduced into the trachea of young rabbits for further development. This was effected by tracheot omy, but the animals rapidly recovered from the affects of the operation, and in a short time became effected with a cough the same as whooping cough. The rabbits were killed and their air passages and lungs were found to contain innocuous quantity of fungus. The expectorated mucus was also the same as in man.

From Le zerich's valuable investigations he was able to show the difference between the action of the fungus in diphtheria and that in whooping cough.

He says:

- Diseases produced by the vegetation of fungi in the epithelium stratum of the respiratory organs are of two kinds;

1st. Diphtheria.-The vegetation of the fungus originates at the head of the windpipe and trachea, and seizes and destroys the epithelium with startling rapidity.

2d. Whooping Cough.-The fungus vegetation germinates in the epithelium web, at first in the upper part and then over the whole respiratory organs, with out destroying the web, produces whooping cough and its manifold complications. If the growth of the fungus is confined to the epithelium of the epiglottis of the

larynx and trachea, then it is simple whooping cough; but if the fungus enter into the delicate bronchial tubes and the cavities of the lungs, then the dreaded complications arise.

It is therefore best to meet the disease in its earliest stages and treat it properly; that is, with an object to kill the fungus and prevent its further development, and then we shall seldom have the complications of bronchitis, cholera infantum, or cerebral difficulties to contend with.

What, then, shall be the proper remedy?

Quinine has been used for a long time with excellent results, but its use was not founded on the fact that it kills fungus plants; it was not so used until 1869, when Prof. Binz made numerous experiments to show that it would check very markedly the alcoholic fermentation in various fluids, and that this antiseptic action was due to the poisonous influence of the drug upon the fungi, which are the cause of such fermenta tion. According to his experiments, the largest infusosia are killed by a solution of quinine of the strength of 1 in 800 immediately; and upon the ordinary mould penicillum, upon vibrios and bacteria the drug acts with a similar fatality. In the latter part of 1870 Prof. Binz, and later in the same year, Breidenbach, published articles on the beneficial action of quinine in the convulsive stage of pertussis.

Their application of this drug indicated that they thought pertussis was due to the growth of fungi; but still this had never been demonstrated until Letzerich undertook the investigation,

In 1871 Steffin confirmed in the main the accuracy of the observations of the savants mentioned above; and two years later Dr. B. F. Dawson reported eighteen cases in a valuable pamphlet, and advocated strongly the value of quinine in curing the whooping in this disease. Since then the use of quinine has been ably defended by Dr. Hamilton of Jerseyville, Ills., and Dr. Chas. W. Earle of Chicago. My experiments lead me to the same conclusion, as after administering quinine to my children, and in fact to numerous other children, they all speedily recovered, not whooping more than once a day after the third day it was given them, and discontinuing to whoop entirely by the end of the fifth or sixth day.

The time could be made much shorter if children could be induced to take it in a powder directly on their tongue and let it dissolve slowly, but owing to its extremely bitter taste they object; so I found by dissolving the quinine in gum, that is to say, sugar and water, they soon became accustomed to the taste and craved for it, as it afforded them relief. The best time to administer it is just after a coughing spell and just before retiring at night. As regards the size of dose, this should depend on the age and severity of the case. To a grown person, from three to five grains of powdered quinine can be put right on the tongue and allowed to dissolve itself; to a child, from two to five grains may be dissolved in two ounces of gum (sugar and water) and one teaspoonful can be given as stated above. The gum helps to keep it in contact with the parts longer. Quinine administered in gelatine or sugar coated pills is of no use whatever.

* Virchow's Archiv. 1869. p. 68. Wood's Therapeutics Materia Med, and Toxicol. P. 62.

NUTMEG POISONING.-E. R., æt. 36, was delirious, pulse was accelerated and feeble; great prostration; pupils dilated; temperature about normal; stupor. On inquiry, found that about three o'clock that afternoon he bad eaten a large nutmeg, and about seven in the evening symptoms of drowsiness and stupor set in, which increased till 9 o'clock; thirty drops of aro matic spirit of ammonia, in brandy, every three hours. Strong coffee given freely; free from unpleasant symtoms, but somewhat weak.

C

REMARKS ON YELLOW FEVER.

BY JOSE J. NAVARRO, M.D., OF SANTIAGO DE CUBA. During the sojourn in Cuba of the Medical ComGission appointed by the United States for the study of the nature and causes of yellow fever, the Governormeneral of the island appointed a Spanish medical committee to aid the American commission in its noble and humane task. This Spanish committee sought information from the several boards of health through

out the island.

The circumstance of my being secretary of the State Board of Heal h in this province (Santiago de Cuba) gave me peculiar advantages for comparing the reports of fourteen county boards of health existing in this province. As all of these reports passed through my hands, I was gratified to observe that the deductions made from them agree with the opinion expressed in the Special Report of the Homeopathic Yellow Fever Commission ordered by the American Institute of Homœopathy for presentation to Congress, viz. :

Yellow fever is a specific disease. In this country the fever never attacks a second time the same person. It originates from local causes, the most potent of which is decomposition of vegetable matter in the water. It shows greater virulence and malignity where there is mixture of sweet (river) water with salt (sea) water. It very rarely attacks Cubans, unless in exceptional cases, when, after having lived from early youth in the high mountains, they remove to Its range is infected places during the fever season. limited to the seashore, especially in low, marshy places. The disease has never been known to appear in inland places or high mountainous land. The fever season is the summer and fall; that is, when heat and dampness predominate from the heavy rains. Very few cases appear in winter, and these are almost invariably fatal. The disease can be propagated by infection through families.

The report from Baracoa is curious and interesting, and seems to be an exception to the general rule. That city, the oldest in the island, is situated on the extreme northeast end, close by the open sea, and bounded east and west respectively by two rivers, both large enough to be navigable. The surrounding land is low, and vegetation luxuriant. In spite of these circumstances, so favorable to the development of yellow fever, the report says that it has only twice made its appearance, and then in an epidemic form, and in both cases imported; the first time, thirty years ago, it was introduced from Martinique; the second, four or five years ago, from Havana. Thus we see that in this place the disease does not occur sporadically, not even among the troops, who, from their European origin, are consequently certain victims of this fever. How may these facts be explained?

The mortality is far greater under allopathic than Aconitum, Arsunder homœopathic treatment. enic, Belladonna, Bryonia, Carbo veg., Crotalus, Lachesis, Nux comica, etc., have always done their work nobly. But during the last fifteen years a revolution has taken place; all these well tried friends have been dethroned by a new indigenous remedy, which might justly be called a specific by those who favor the theory of specifics.

I have already mentioned this new and important agent in a paper sent to the World's Homœopathic Convention; but, as the Transactions of the Convention have not yet been published, and yellow fever has latterly caused great ravages in the southern parts of the United States, it may not be superfluous to make a few explanatory remarks on the history of this remedy.

noticed that Dr. Victor Iturralde, a native of Spain, and one of the most learned and accomplished physicians that ever visited this island, met with most extraordinary success in the treatment of this disease, curing every case of which he took charge. In fact patients in the last stage, given up as hopeless by other homoopathic physicians, were saved by Dr. Iturralde, if called in consultation. This gentleman's success was so striking that the allopathic practitioners themselves began to surrender their cases to him when considered fatal. These 'results were attributed by many to the superior knowledge and skill of Iturralde, and by others to merely "good luck." It was, however, afterward ascertained that Iturralde possessed a new remedy prepared by himself from a Cuban plant, and this was the efficacious preparation with which he conquered yellow fever.

Rev. Father Callejas, a very pious and learned priest who, as an amateur, was devoted to the practice of homoeopathy gratis, and aided greatly in its dissemination, in his Manual, published in 1866, speaks of this discovery as follows: "On the eve of his departure for Europe, Dr. Iturralde called at my house and gave me half an ounce of a tincture, stating that this was a new remedy prepared by himself from a Cuban plant, and had been the secret instrument of his sucHe requested me to try it in every case of yelcess. low fever submitted to my trea ment, and report my experience to him. I begged him to reveal the name of the plant, but he steadfastly declined, alleging that he did not consider it sufficiently tried. He added that when he was convinced of its thorough trial, he would present the drug with its pathogenesis to the Hahnemannian Society of Madrid for publication to the world."

Shortly after his arrival in Spain Dr. Iturralde died, carrying with him, as was supposed, his secret to the grave. This circumstance caused Father Callejas at that time to slight the medicine, for he did not feel justified in making use of an unknown substance in so grave a form of disease as yellow fever For this reason, although he made dilutions of the 3d, 6th, 12th, and 30th centessimal potency, he did not employ the remedy until the next year, when he decided to try it in a desperate case, in which he experienced highly satisfactory results. Father Callejas continued its use, and always met with uniform success.

He gave some of his preparation to several physicians of the homoeopathic faith. the writer among them, and the result of its use has always been entirely successful. Dr. Avilés, at that time in charge of the Charity Hospital, used it in 103 cases, with only two Although not a believer in specifics, for I deaths. hold that individualization of disease and remedy is the surest and only scientific base for a correct prescription, still the great success attending this remedy, not only in genuine yellow fever, but also in some of our tropical fevers, gastric, bilious, etc., when the symptoms resemble yellow fever, moves me to recommend this substance to the profession. Not knowing the name of the plant which contains such precious medicinal power, we called the remedy Fiebre amarilla (yellow fever.)

In conclusion, I will cite from my notes a few cases to illustrate the action of the Fiebre amar:

In July of 1874 was called to a tend Mrs. P. de V., aged 25, a native of England, and of lymphatic constitution. Had resided from infancy in Portugal; married to a Cuban gentleman. After a residence of six or eight months in this city, was taken with chills, followed by high fever and severe headache. I saw her 26 hours after the occurrence of chills, at 5 PM., and found the following symptoms: patient lying on her back; face pale, with flushed cheeks; restlessness, About the years of 1863 and 1864 we experienced a with extreme anxiety and fear of death; great thirst; terrible yellow fever season, and although homoeop-headache worse on moving the head; tongue natural; athy, as usual, triumphed over its rival system, it was pulse 98; complained of chilliness when uncover

ing any part of her body. Aconitum 3, one dose
every three hours. Called again in the morning, 7
A.M., and found the same symptoms, rather increased,
with these additions: tongue dry, and coated white;
severe pain in the stomach, with frequent nausea and
bitter taste in the mouth; bruised, tired feeling all
over the body, with violent pains in the waist and
down the thighs, following the course of the sciatic
nerve; pulse 102, small and soft; tendency to perspira-
tion on the upper part of the body. Fiebre amar, 30,
every two hours. At 5P.M.I found the following change:
pulse 112, small, soft, and compressible; lower tem-
perature; great prostration; subdelirium; had vomited
six times; while I was at the bedside she threw up
about two ounces of black vomit exactly resembling
coffee grounds; icterus commences to appear on the
conjunctiva and skin. Fiebre amar., 30, every hour.
Returned at 6 A. M. next day; found that the patient
had vomited twice in the early part of the night, ejecta
consisting of pure bile; the nausea had ceased since
10 P. M.; warm perspiration all over the body; mind
quite clear and calm; pulse 102; less thirst; had slept
twice; about half an hour each time; icterus quite de-
veloped; tongue not so dry. Fiebre amar., 30, every
three hours. At 5 P. M. pulse 98; tongue begins
to get clean: icterus decreasing, no pains, no thirst,
no nausea; urine free and copious, with slightly yel-
low tint; bowels have acted once quite naturally; pa-
tient says that she feels relieved. Fiebre amar., 30,
every four hours.
At 7 A. M. next day obvious im-
provement; pulse 88; copious perspiration; slept the
greater part of the night; turns herself in bed; tongue
almost clean and moist. Fiebre amar., 30, every six
hours. At 5 P. M. pulse 85; heat of the skin almost
natural; tongue quite clean and moist; no pain; had
slept several times during the day; says she is much
better. Placebo. Next day at 7 A. M. no fever; pulse
76; normal heat; has slept the entire night; feels very
well and asks for "something to eat, as she feels quite
faint and hungry." No medicine; chicken broth allow-
ed. From this day convalescence commenced and
continued without further trouble. Two days after-
ward the patient passed a tenia solum, measuring
about three yards, including head, which had trou-
bled her for many years.

We have here a severe case of yellow fever whose tableau of symptoms was so complete as not to leave the least doubt about the diagnosis, running its course in five days, with no medication or external auxiliaries but the precious Fiebre amarilla, 30, administered internally.

8 A. M., pulse 92; conjunctiva and skin slightly but visibly tinted with yellow; pains abated; no thirst, no pain in the head; tongue clean and moist; no vomiting nor nausea; slept almost all night. Continued the same medicine every four hours. 6 P. M. no fever, no pain; pulse 86; natural temperature; conjunctiva and skin quite normal in color; patient in good spirits, but complaining of hunger. No medicine; allowed to take twice during the night half a teacup of iced milk. 8 A. M., pulse 84; patient slept all through the night and feels quite well and contented. Is very hungry, and begs to be allowed to leave his bed. Advised him to keep in bed, and ordered chicken broth. Canvalescence began, and a rapid recovery followed.

August 15th, 1877.-I was called at 3 A. M. to see D. R. C., æt. 42, a native of Barcelona, Spain, who, according to the message, was not expected to live half an hour longer. I found him in the 3d day of yellow fever, and in a state of collapse. I learned that he had been treated from the beginning by allopathic physicians, who held several consultations. In the last one, half an hour before, the patient was declared to be dying. As a matter of course, the usual energetic regular treatment had been resorted to; the last means employed were stimulants in the shape of preparations of Ammonia internally; subcutaneous injections of Sulphate of Quinine, frictions, mustard poultices, and four blisters on the limbs. I was informed that the symptoms of yellow fever had been complete, even the black vomit had taken place twice the previous day. The state of the patient was as follows: Position supine, with complete relaxation of all the muscles; features pinched; eyes glassy; breathing stertorous and sighing; skin cold, pulse small, frequent, flickering, intermittent. Carbo. veg, 200, one dose every 10 minutes. Dry frictions on the skin and hot applications to the extremities; removed blister, synapisms, etc. After the fifth dose reaction commenced, so that when I saw him again, two hours later, the scene was completely changed; the patient was now very restless; skin very hot; face flushed; eyes bright and sparkling; strong delirium with rage; pulse 110, hard, full, and bounding. Aconitum 30, and Belladonna 30, alternately every two hours. Four P. M., less fever; pulse 102, full but soft; temperature lower; no delirium; patient more tranquil. On the other hand, there was nausea, severe pain in the stomach, waist and lower limbs; violent thirst, and yellowish tint on the skin. Fiebre amar. 12, every two hours.

August 16, 8 a, M., very little fever; pulse 94; no

amar. 30, every four hours. Five P. M., no fever; pulse 85; skin normal in color and temperature. No medicine. Next morning convalescent.

August 15th, 1874.-J. G. æt. 12, a native of San-pains, no nausea, no thrist; patient calm. Fiebre tander, Spain, strong, robust constitution, sanguine temperament, never been ill, except in infancy, when he had the measles in his native country. Seven weeks after his arrival in Cuba was taken with fever, which It would be an endless task to cite the numerous commenced about 6 A. M. At 4 P. M. he began to be cases of yellow fever in which Fiebre amar, has been a restless, and in half an hour afterward was taken with curative agent in my hands. I have selected only convulsions and I was sent for. The condition of the three cases, in which the symptoms are so characterpatient at my first visit, 5 P. M.; was as follows: Vio-istic of the disease, that there can be no room for doubt lent fever; skin very hot; feet cold; pulse 112, hard as to diagnosis; omitting reference to those in which and full; general convulsions, occurring every fifteen the disease was not allowed to develop itself, by the or twenty minutes; respiration accelerated; tongue timely use of this precious remedy. I could cite hunprotruding from the mouth; strabismus; copious per-dreds of cases where the symptoms of the initiatory, spiration on the forehead. Veratrum viride 3x, one drop every twenty minutes, and hot applications to the feet. Called again at 9 P. M.; convulsions have subsided after the 3d dose of the medicine; natural heat in the extremities; pulse 98; violent dilirium; tries to strike and bite those around; pupils dilated; starts at the least noise or light. Bell., 200, every two hours. Next day, 7 A. M., pulse 96; no delirium; complains of severe pains in the waist and limbs; trequent nausea. Fiebre amar., 12, every two hours. 5 P. M., has vomited twice pure bile; pulse 94; general warm perspiration; pains the same, but patient more quiet. Fiebre amar., 30, every three hours. Following day,

and even those of the first stage, were entirely suppressed after the second or third dose of this remedy; thus practically demonstrating that by its early administration it possesses the power of destroying the principius morbi, or, as it is often called, the germ of the disease.

It is worthy of notice that in these three cases the remedy has been used singly and alone, for the reason that I was desirous, by careful observation, of determining what Fiebre amar. could accomplish unaided in yellow fever. The result of these and many other experiments has been to convince me of the great efficacy of this medicament in the disease under con

sideration.

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