manganese in the blood, as well as the fact that chlorosis is not only due to a reduction of iron, but also to a proportionate decrease in manganese, and that this loss must be equally compensated, and the important part played by this metal in the absorption of oxygen by the blood gave rise to repeated experiments to produce a preparation by a combination of iron and manganese, which would be easily absorbed and the composition of which resembled that in which these elements are present in the blood. For a long time, however, the accomplishment of these aims was only a pium desideratum. Neither the acid, alkaline, or other combinations of these two metals, which were based upon experience or theory, or last, but not least, upon commercial considerations, were able to gain a permanent place in ferruginous therapy. In Gude's Pepto-Mangan alone are these requisites completely fulfilled and realized, and in this preparation the disadvantages belonging to other chalybeates have been obviated in such a manner and with such certainty as had previously been pictured as unattainable by the pharmaceutical chemist, and which stamps the liquor mangano-ferri peptonati as a true medicinal agent. It is a clear, dark-red fluid of an agreeable non-metallic and non-astringent taste. It contains iron and manganese in the proportion of 3 to 1, combined in the form of a peptonate, which is unaffected by an acid or alkaline reaction and never gives rise to unpleasant by-effects. Permit us to make the following prefatory remarks: The manner in which medicinal iron is absorbed and assimilated in the human organism has been of the greatest interest to the experimental physiologist, and for this reason numerous investigations have been made in order to determine the assimilability of iron in the body. We would refer to the work of Quinke who presented an important contribution on such experiments to the Congress for Internal Medicine in 1896. To the medical practitioner, however, the point of paramount importance is the degree of efficiency of a ferruginous remedy, and Pepto-Mangan has the great advantage over all other chalybeate preparations in that it contains manganese, to which great value has been ascribed in the formation of blood, and to which attention has been directed particularly by Heitzman (Ueber Anwendung und Wirkung des Mangan-Eisen-Pepton Gude). He says: "After Hannon had recognized the great significance of manganese besides iron in the oxygenation of the blood, and this discovery had been verified by Ruehle, attempts were made to produce combinations of both these remedies which would conform in every respect to the therapeutic requirements. Former experiments of this kind did not lead to the desired results. The purpose in view was to find a form of both metals in which they would be absorbed by the entire digestive tract, and, furthermore, would be devoid of any unpleasant taste which might prevent their continued administration. After various experiments I found that the preparation of Dr. A. Gude, pepto-mangan, was the one conforming in every way to the above requirements, so that I am able to recommend it most highly." Another equally positive opinion is given by Pohl (Ueber Liquor mangano-ferripeptonati Gude), who remarks: "A large number, almost all, of the officinal ferruginous preparations are absorbed only to a slight extent when administered internally. This can be maintained on the ground of the fact, that in animals and human beings positive evidence of the entrance of these preparations into the blood cannot be obtained if the persons experimented PASSIFLORA DANIEL'S CONCT. TINCT. PASSIFLORA INCAR- Sample Supplied, Physician Paying Express Charges. LABORATORY OF JOHN B. DANIEL, Atlanta, Ga., U.S.A. The Largest and Most Thoroughly Equipped of Sanitariums The Battle Creek Sanitarium management were the first to organize a thoroughly complete system of physiological therapeutics. Water-cures had existed before-eclectic institutions, mineral springs, and similar establishments-but the Battle Creek institution was the first to organize a system and method embodying all physiological agencies. One hundred and seventy-five rooms with private baths; six hydraulic elevators; electric lights and private telephone in each room. Spacious parlors on every floor. Roof garden, dining-room and kitchen at the top. Beautiful outlook from every window. Accommodation for eight hundred guests. Staff of thirty doctors; three hundred and fifty nurses. Nearly forty years' experience in this institution has demonstrated that the great majority of chronic invalids of all classes, including many considered incurable, can be trained up to a state of healthful vigor by a systematic regimen based upon scientific principles, combined with a thorough-going application of the resources of hydrotherapy, phototherapy, thermotherapy massage, Swedish movements, Swedish gymnastics, electrotherapy, and the open-air treatment, guided by the exact finding of bac teriological, chemical, microscopical, and other accurate methods of examination. Special ward for surgical cases, with perfect appointments. For information concerning the facilities afforded, terms, etc., address THE SANITARIUM BATTLE CREEK, MICH. When writing advertisers, please mention THE CANADIAN JOURNAL OF MEDICINE AND SURGERY. with have not intestinal catarrh or have not received excessive doses of iron. The more the preparation approximates to the form in which iron is contained in the food, the more likely it is to be absorbed. The peptonization of an iron preparation is therefore of decided advantage, as its absorbability and assimilability are thereby enhanced to, a considerable degree. Aside from this, the peptone combination is adapted for exerting the systemie effect. This general action of iron preparations only takes place if after absorption they undergo conversion into hemoglobin. Hence this conversion is only possible in the case of preparations which contain iron in the form of an organic combination. They will then act even when containing a much smaller precentage of absolute iron." Hoenigschmied (Liquor ferri-mangano-peptonati Gude) refers to the value of pepto-mangan in the following words: "The fluid preparations of iron which are administered in the form of oxydules or oxyds have the disadvantages of acting as astringents upon the stomach and intestine, of etarding peristalsis, and of usually causing a diminished secretion of gastric juice, in consequence of which digestion is impaired and constipation not infrequently produced. The well-known iron albuminates and the alkaline saccharated iron, owing to their excessive amount of soda alkali, neutralize the gastric juice, thus giving rise to an abnormal condition of the digestive secretions. Dr. A. Gude, chemist, of Leipsic, has succeeded in producing an iron preparation which renders prompt service, and which owing to its composition does not interfere with the digestion in any way, does not change the gastric juice, and, it would appear, is readily and completely absorbed." Ripperger (Einige Bemerkungen ueber die Eisenbehandlung bei Chlorose und speziell ueber das Mangan-Eisen-Pepton Gude) finally says: "In reviewing the facts we are able to state that Gude's pepto-mangan is a very useful and easily assimilable chalybeate which does not disturb the digestive tract. She "On May 3rd I was consulted by a young married woman, 23 years old, who on first sight presented the picture of a severe chlorosis. stated that she had always been very pale, and since her first menstruation had suffered with severe general disturbances. The menses first appeared in her seventeenth year and were very irregular. Sometimes they lasted only three days and were scanty, and sometimes for eight days, with a profuse flow. This condition had persisted until recently. About a year and a half ago she suffered with a gastric ulcer with profuse hemorrhages. Her object in seeking medical advice was for the relief of attacks of vertigo and severe dull headaches. She could go up stairs only with great difficulty on account of palpitation of the heart and dyspnea. The diagnosis was made from the statements of the patient and her appearance. I ordered Pepto-Mangan with an appropriate diet. Much to my delight she experienced an improvement as early as at the end of the second week. At that time the attacks of vertigo and the pressure feelings in the head had completely disappeared although the patient still looked somewhat pale. She continued treatment and after another eight days a marked objective improvement could be determined. The mucous membranes had regained their normal color at the end of four weeks. In June the patient stated that she felt completely well and that the menstrual disturbances had entirely disappeared. Blood examinations: May 5th, Hemoglobin, 25 per cent.; May BAYER'S PHARMACEUTICAL PRODUCTS SOMATOSE A tasteless, LOSOPHAN (Triiodometacresol). odourless Particularly efficacious in Trade Mark. nutrient meat powder; it con- the treatment of all kinds of cutaneous disorders tains all the albuminoid principles of the meat caused by animal parasites. in an easily soluble form. It has been exten TANNIGEN (Triacetyl of Tannin). An sively employed and found to be of the greatest service in Consumption, diseases of the stomach and intestinal tract, Chlorosis and Rickets. is of great value in convalescence from all grains every three hours. diseases. SOMATOSE strengthens the muscles and stimulates the appetite in a remarkable manner. SOMATOSE has been found to act as a most efficient galactogogue. Dose for adults: a level teaspoonful three to four times a day with milk, gruel, coffee, etc. IRON SOMATOSE (Ferro-Somatose). A first-class tonic. containing the albuminous substances of the meat (albumoses) organically combined with iron. Special indications: Chlorosis and Anæmia. Daily dose : 75 to 150 grains. MILK SOMATOSE (Lacto-Somatose). A strength-giving food containing the albuminous matter (albumoses) of the milk. Daily doses for children: I to 2 teaspoonfuls; for adults: 2 to 3 tablespoonfuls. almost tasteless intestinal astringent. Most efficacious in Chronic, Acute It and Summer Diarrhoeas. Adult dose : 8 TANNOPINE (A new intestinal astringent). (Formerly "Taunone"). Special indications: Tuberculous and non-tuberculous Enteritis, Typhus. Dose: 15 grains, three or four times daily. SALOPHEN (Acetyl of Para-Amidosalol). Specific for Influenza, Headache, Migraine, Acute Articular Dose: 15 Rheumatism, Chorea, Sciatica. grains, four to six times daily. In powders, etc. ANALGEN (Ortho-Ethoxy-ana - Monobenzoylamidoquinoline). A specific for Malaria. Highly recommended in Acute Rheumatism of the Muscles, Sciatica, Facial Neuralgia, etc. paroxysm of fever 20 to 30 grains; between the fevers 15 grains every 3 hours. Rheumatic affection and Sciatica: 15 grains, 4 to 5 times daily. The use of ANALGEN is accompanied by a reddish coloration of the urine, which, however, is not produced by the presence of blood corpuscles. The red color of the urine may be avoided by taking alkaline waters. the thyroid gland. It PHENACETINE-BAYER (Acetyl TRIONAL (Diethylsulfonmethylethylmethan). A most reliable and quickly-acting hypnotic of the Sulfonal group. Dose: 16 to 20 grains, in a large cup of hot liquid. IODOTHYRINE The active principle of Phenetidin). Malaria before the of Para An excellent substitute for is most efficacious in Strumous Diseases, Myx- (Diethylenediamine). HEROIN (Di-acetic ester of mo1phine). codeine. In doses of 0.005 gramme, 3 to 4 times daily, it has given excellent results in cases of Bronchitis, Pharyngitis, Laryngitis, Catarrh of the Lungs in phthisical persons, and in Asthma Bronchiale. In the latter two cases, the dose may be increased to 0.01 gramme. CREOSOTAL (Creosotum carbonas recommended for Burns, Wounds, Scrofulous puriss). A mixture of Ulcerations, etc. the phenol carbonates of creosote. Most valuEUROPHEN (Isobutylorthocresolio-able in tuberculosis of the lungs Doses of 1/2 dide). A perfect substi- to 5 drachms per day, in wine, brandy, or cod tute for Iodoform. Odourless and non-toxic. liver oil. Has a covering power five times greater than iodoform. Especially useful in Ulcus molle et durum. PROTARGOL A new silver preparation. DUOTAL (Guaiacolum carbonas puriss). Great success in cases of Pulmonary Phthisis. Doses of 8 to 96 grains per day. methylmethan). Most reliable in cases of SULFONAL-BAYER(DiethylsulfondiGonorrhoea. Antiseptic wound healer. Excellent results in cases of Gonorrhoeal Ophthalmia. SALOL-BAYER (Phenyl Ether of SaliSolutions of 4 to 2° Ointments. Samples and literature may be had on application to the cylic Acid). DOMINION DYEWOOD & CHEMICAL CO., TORONTO. Sole Agency and Depot in Canada for all "BAYER'S' Pharmaceutical Products. (Wholesale only.) When writing advertisers, please mention THE CANADIAN JOURNAL OF MEDICINE AND SURGERY. 10th, 30 per cent.; May 16th, 40 per cent.; May 20th, 55 per cent.; May 25th, 65 per cent; and June 3rd, 85 per cent. "At the end of February of last year I was summoned to see a primipara, 28 years old, who after delivery had a profuse hemorrhage from the uterus owing to the retention of the placenta. I found it necessary to detach it with the fingers. After this procedure so severe a hemorrhage occurred from the uterus that the woman became collapsed. The pulse was threadlike, and could scarcely be felt, and her skin was of a death-like pallor. Infusion of saline solution was resorted to and several stimulants administered, and her death thus prevented. The patient remained four weeks in bed, but convalesced very slowly, although the utmost care was observed in the dietetic and medicinal treatment. The use of the non-fluid iron preparations had to be discontinued, because they occasioned gastric disturbances and impaired the appetite. I therefore advised her to take a fluid preparation, and ordered Pepto-Mangan. The patient took this preparation willingly, because of its agreeable taste, and because she noticed that it increased her appetite. Even after a few days she was able to leave her bed, and although still pale she had been freed of her subjective disturbances. Under the continued use of Pepto-Mangan the pallor of the face disappeared and made way for a healthy color." THE TREATMENT OF ECZEMA. CHARACTERIZED by pustular inflammation, great itching and exudation, this disease is, perhaps of all dermatoses, most frequently encountered by the physicians. So far as the constitutional treatment goes, the aim of the physician should be to get the patient into the best state of health he can, and thus the treatment may vary with the individual. It is interesting to note in connection with the constitutional treatment, that whereas arsenic was once largely prescribed, it is now falling into desuetude among the more enlightened, who regard it, not as a specific, but as likely to aggravate inflammatory conditions. Most authorities are agreed in interdicting alcohol. In the more important local therapy, reduction of the inflammation and exudation is indicated. First the eczematous crust must be removed: this was formerly done by soaking the entire surface in almond oil, or by applying starch poultices. Soap and water were forbidden, since they tended to irritate the skin and retard the recovery. There is little doubt but that ordinary soap does this; but the crust can be removed by the use of Resinol Soap and warm water without any fear, since it, by reason of properties allied to those of the Resinol Ointment, exerts a benign and soothing influence, and thus not only benefits the patient, but facilitates the work of the physician. When the crust has been removed, Resinol Ointment should be applied, and repeated every six or twelve hours, according to the irritability of the eczematous surface. Relief will be immediate. It is better to spread the ointment on strips of thin muslin, gauze or lint. In eczema of the head it will be found easy to devise a helmet or mask. Resinol is not a newly-born remedy, but has been prescribed, and continues to be prescribed, by the leading physicians in the United States and Canada, who testify by consistent use their active belief in its merits. |