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A LABORATORY GUIDE

in

PHARMACOLOGY

By

TORALD SOLLMANN, M. D.

"

Professor of Pharmacology and Materia Medica in the School of
Medicine of Western Reserve University, Cleveland

ILLUSTRATED

PHILADELPHIA AND LONDON

W. B. SAUNDERS COMPANY

1917

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PREFACE

THE following exercises are designed to introduce the student personally to some of the more important facts of pharmacology. They have been selected so as to present little difficulty to one versed in ordinary chemic and physiologic technic, and require but little help on the part of the instructor.

The pharmaceutic and toxicologic exercises (Part I) are confined strictly to the bare essentials needed by students who intend to become general practitioners of medicine. Especial stress has been laid on the facts which have a direct practical bearing.

The experiments on animals (Part II) have been arranged in groups, to illustrate various types or phenomena, to bring out the similarities and differences of the response of organs to pharmacologic agents, rather than by individual drugs. This arrangement articulates better with the student's experience in physiology and pathology, on which pharmacology is largely founded. It is, therefore, more natural, as well as more interesting and inspiring. It has been the practice of the author to have this experimental course precede the didactic course. The latter, dealing with individual drugs, can then be based upon phenomena with which the student is already familiar.

The exercises are arranged for a course of thirty working periods of two to three hours. Additional experiments, for longer courses, demonstrations, etc., are introduced as optional. They can, of course, be indefinitely extended by the use of dose tables and of the "Technical Notes." These are intended primarily for the instructor and investigator, indicating the sources where more detailed information and different methods may be found.

II

THE USE IN THIS VOLUME OF CERTAIN PORTIONS OF THE TEXT OF THE UNITED STATES PHARMACOPOEIA IS BY VIRTUE OF PERMISSION RECEIVED FROM THE BOARD OF TRUSTEES OF THE UNITED STATES PHARMACOPOEIAL CONVENTION. THE SAID BOARD OF TRUSTEES IS NOT RESPONSIBLE FOR ANY INACCURACY OF QUOTATION NOR FOR ANY ERRORS IN THE STATEMENT OF QUANTITIES OR PERCENTAGE STRENGTHS.

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