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In order to prove the efficiency of GLYCOZONE, I will

send a

$1.00 bottle free

to Physicians accompanying their request with 25c. to pay forwarding charges.

A copy of the 18th edition of my book of 340 pages, on the "Rational Treatment of Diseases Characterized by the Presence of Pathogenic Germs," containing reprints of 210 un

Prepared only by

Charles Marchand

solicited clinical reports, by leading contributors to Medical Chemist and Graduate of the "Ecole Centrale des Literature, will be mailed free of charge to Physicians mentioning this Journal.

Arts et Manufactures de Paris" (France) 57-59 Prince Street, NEW YORK.

Look well to your prescriptions-a careless or dishonest pharmacist may ruin your reputation.

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(Each Tablespoonful contains 2 minims of Creosote and 8 grains of Hydrochloro-phosphate of Lime.)



(Each capsule contains: Iodoform, 0.02 centigrammes; Phosphate of Lime, 0.15 centigrammes

Creosote, 0.05 centigrammes.),

Successfully Prescribed by Best European Doctors for 25 years, in all kinds of Tuberculous Affections, especially those of the Lungs and Bones, Chronic Bronchial and Pulmonary Affections, Convalescence from Pleurisy and Broncho-Pneumonia, Influenza, Measles, Whooping-Cough, Scrofula and Rickets.

Dollar Bottle to Physicians willing to pay expressage.

GEO. J. WALLAU, Special Agent, 2 Stone Street, NEW YORK.

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GEO. J. WALLAU, U. S. Agent, 2 and 4 Stone Street, NEW YORK, N. Y.

A careful physician and an honest pharmacist—a strong combination united for the patient's welfare.

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Treatment of Diabetes Mellitus.-From treating a great many patients with diabetes mellitus with papine I have the experience that I have yet to see a patient that could not stop taking the papine at any time I so directed him. It does not seem to cause the least desire for its continuance, or to create the least disposition to the formation of a drug habit. This has proven itself to me on several occasions when I have had occasion to administer the drug for six or more consecutive months, and the patient be able to stop at the end of that time with no bad effects or symptoms, which would surely have occurred had I prescribed opium or any of its preparations commonly in use today. With that reputation at its back, I use it more and more promiscuously today than ever before, and am pleased with its results. Dr. J. W. Pearce, in Medical Brief.

Eusoma for Inflammation and Abraded Surfaces of the Rectum.-I take pleasure in saying that after using your echinacea compound (Eusoma) for inflammation and abraded surfaces of the rectum, it has proven very satisfactory and efficient. Personally, I suffered many years from rectal troubles of all kinds, short of fistula; having submitted to ligations, cautery and injections at least twenty times; the last hypodermics being about ten years ago. Since then I have had more or less trouble from ulcerations and small hemorrhoids. I have now been using eusoma on a swab, in full strength, when conscious of discomfort or trouble of any kind, with the most satisfactory and comforting results, even the tumors disappearing after a few daily applications. I feel grateful to you and the Eusoma Co. for having brought so efficient a remedy to my notice--M. H. Fletcher, M. D., 11 E. Seventh St., Cincinnati, Ohio.

Dysenteric Conditions all present certain physical signs which are in common, such as the frequent stools, great exhaustion and weakened heart action dependent upon the virulence of the poison. Recognizing this toxic manifestation and the constantly increasing danger of autoinfection, our indicated treatment is one which will assist the effort nature is making to render the tract aseptic by ridding itself of the contents of the bowel which has been a fertile field for disease producing germs, to correct the existing fermentation and restore surface circulation which has been seriously interfered with. For this purpose a high colon flush of glyco-thymoline in a 10 per cent solution at 105 deg. should be used at least twice daily. This solution exerts a marked inhibitory effect upon the growth of putrefactive and pathogenic bacteria, depleting the membrane of its products of inflammation and restoring normal glandular secretion.

I hereby volunteer to make a few statements regarding your product known as resinol soap. I have found it to be a wonderful article for treatments of itching scalp. I have had some erysipelas taint in my system for about two years or may be longer. It began, a few months ago, to take on a very aggravating form on my scalo. There were scales and rash and two small lumps formed upon and within the skin on the scalp. It occurred to me that resinol soap might be beneficial if used for a shampoo. I procured a cake of the soap and took it to my barber and requested him to use it freely on the scalp and rub it into the scalp very thoroughly, and then dry the hair with dry towels, not washing the soap off, but leaving it on the scalp in order to get the full benefit of the medicinal qualities of the soap. This treatment leaves the hair in a fine condition, and the result of this treatment upon the scalp was amazing. I was delighted to be so completely and entirely relieved of the itching, I have my scalp treated with the resinol soap once a week for the past few weeks, resulting in one of the lumps in the scalp disappearing entirely and the other lump is nearly gone. I have also found the resinol ointment the best I ever used for eruptions on the skin. It is not only a wonderful healer, but it is of such pleasing consistency that it is a pleasure to apply to the most sensitive parts. I am enthusiastic over these two healing articles, resinol soap and resinol ointment. You are at liberty to make it known to the public the high esteem in which I hold these two remedies.-H. A. Cross, D. D. S., 560 E. 55th street, Chicago, Ill.

Modern Civilization as a Factor in Causing Diseases of Women:-(By N. H Kassabian, A. B., M. D., Coopersville, Mich.)-A woman, physically perfect, is certainly a unique creature in modern times. Our civilization has contributed very extensively to the causation of female maladies which we are so frequently called upon to treat. Our modes of living and dressing exert a very deleterious influence upon the normal functions of the pelvic organs, not to mention the hepatic compressions and subsequent displacements resulting as a natural consequence of tight-lacing practiced by the most humble devotees of the temple of fashion. We are a very progressive race, taking herculean steps towards a higher civilization; but it is a deplorable fact that the more we learn the more we ignore the most fundamental laws of hygiene. The immediate effects of tight-lacing are, that abdominal and spinal muscles are seldom brought into play, so they become atrophied. The viscera are thus compressed and displaced, and the full play of the abdominal wall and the descent of the diaphragm are interfered with and the vencu blood is hindered

in its return to the heart. This obstruction of the circulation and the constipation from which women habitually suffer lead to a permanent dilatation of the pelvic veins, a very fruitful source of diseases of the genital organs. And again, customs demand the protection by veil and gloves from the rays of the sun, and the woman soon becomes as bleached as a well-cultivated celery stalk. As the blood needs the direct chemical effect of the sun-light on the skin an anemia is established. This state of the blood is a potent factor in the generation of all the diseases depending on impaired nutrition and entails conditions likely to baffle all medical efforts at their removal during the menstrual life of the woman. Before the altar of fashion and so-called society our girls, while entering to puberty, have to comply with the dictates of the times and at the period of life when the young girl's whole nerve force is taxed for the full development of her organs of generation this force is deflected by hard study, and it may be for the acquirement of some accomplishment which, in all probability, will be forgotten or laid aside after marriage. She is subjected to the emotional influences of music and light literature, which are capable of arresting the normal development of the uterus and its accessory organs. During my travels in the Orient I have been very much surprised to see, specially among races who do not comply with the trivial demands of modern civilization as their sisters do in occidental countries, young ladies grown to womanhood and into maturity experiencing no menstrual irregularities whatever, giving birth to children with normal labor, and through all their maternal life they do not seem to have any especial need to consult a physician. I do not dare, still I take liberty to state that modern civilization and society have immensely contributed to the creation of gynecology, and the majority of patients who make a daily pilgrimage to a gynecologist's office are the poor and pitiable victims of a misdirected and misinterpreted civilization. There are very few maladies which we are called upon to prescribe for as much as for menstrual disorders. A thorough examination with a view of ascertaining, if possible, any malposition of the genital organs should be insisted upon. The least abnormality should have proper attention and local as well as constitutional treatment. Anemia and chlorosis should have their attention, as they almost invariably play a conspicuous part in causing menstrual irregularities. In the form of ergoapiol (Smith), I believe we possess a remedial agent that combines the most effective ingredients with which we can combat the majority of menstrual irregularities. Clinical observations with this preparation are as follows:

Case No. I. Miss A. B. Age 16. Parents both living and in excellent health. She has not had any serious sickness, although on account of there being tubercular diathesis in the family the least abnormality in the functions of any organs is looked upon with suspicion and at once the advice of the family physician is sought. So when Mrs. A. B. noticed that her daughter had an irregular menstruation accompanied with dysmenorrhea she consulted me in her daughter's behalf. I prescribed for her ergoapiol (Smith) capsules, directing her to give one three to four times a day with milk for three or four days before the expected menstrual period. They complied with my directions very faithfully, and after a few weeks they reported that her menstrual disorders had been satisfactorily regulated.

Case No. II. Mrs. B. Age 38. Has two children. Mother died from the result of an operation for appendicitis. Father living and in good health Patient has been anemic for many years, her hemoglobin test showing only 40 per cent. Has at presence prolapse uteri to a slight degree, some perineal laceration and endometritis. Digestion is at fault part of the time, bowels constipated, ringing and buzzing in the head. Menstruates every three weeks. During the first day of the period it is very painful and she flows very profusely,its duration being from a week to ten days. I prescribed for her ergoapiol (Smith) capsules, one three to four times a day, a day or two before the expected menstrual period, to be continued until menses appear, then to discontinue the capsules for three days, and recontinue, commencing on the third or fourth day. The therapeutic action of the remedy was all that could be expected. The dysmenorrhea, which was always a conspicuous feature, seemed to yield after the administration of the first few capsules. She menstruated quite easily and the duration was very moderate. Age 39.

Case No. III. Mrs. Two children, youngest 8 years old. A sufferer from digestive disorders, anemia, and of late, while approaching menopause, she has been having considerable difficulty with her menstruations. At times very profuse and exceedingly painful and again very scant and period prolonged. Having tried a number of preparations without any appreciable benefit to her, decided to use ergoapiol (Smith). She was directed to use a capsule three to four times a day, commencing to or three days before the expected menstrual period. After using this preparation for a little while she reported that she "had not suffered any pains or inconvenience since she began taking those capsules

Case No. IV. Mrs.- Age 38. Married 18 years, four children, youngest four years old. During her menstruation she flows so profusely that she is frightened of a fatal termination. I prescribed for her ergoapiol (Smith) capsules, instructing her to take one after appearances of menstruation, three to four times a day for two or three days until the menstrual flow was controlled. During her subsequent visits to my office I was very much pleased to learn that she has had no trouble to speak of with her menstrual periods while taking the capsules that I prescribed for her.Am. Jour. Surgery.

The Proper Strength of Adrenalin Solutions in the Treatment of Hay Fever.In the treatment of hay fever with adrenalin chloride it has been suggested that weak solutions, frequently applied. are apt to yield better results than the occasional application of a strong solution. One of the pathological features of this peculiar malady is a turgescence of the turbinal tissues due to excessive dilatation of the capillaries. That this is the result of a neurosis involving a more or less pronounced local vasomotor paralysis is pretty generally conceded. Overestimation, by reaction, is very sure to result in a complete paralysis of the vasomotor supply in the region affected. On the other hand, gentle stimulation with weak solutions is not so likely to be followed by a reaction. These views are in harmony with the published observations of Dr. Crile, of Cleveland, O., who found that in a decapitated animal the heart's action was better sustained by the continuous administration of a weak solution of adrenalin chloride. Furthermore, this is probably nature's method of supplying this vital principle to the healthy human body through the agency of the suprarenal gland, its constant presence in the blood in minute amount being sufficient to maintain vasomotor equilibrium.

The School-room as a Factor in Diseases of Young Girls.-There is no disguising the fact that our system of imparting knowledge by imposing excessive intellectual labor and stimulating competitive zeal in the school-room is very largely responsible for most of the nervous disorders of the young women of to-day. That sustained mental exertion is a menace to the health of girls at the age of puberty,there can be no denying. Yet that is precisely the system in vogue at our institutions of learning at the present time. While it is true that modern architecture has greatly improved the hygienic condition of the study-rooms, it is highly probable that the present rush and hurry methods of instruction are even more injurious to the physical state of our young women than was the faulty system of ventilation, until recently endured. The worry and excitement attendant upon present-day school life is, undoubtedly, the prime cause of a governing percentage of the neurotic disturbances which are so prevalent among the women of America. In fact, it is quite within the bounds of truth to assert that many of the diseases which prosent themselves to the gynecologist have for their origin a nervous system rendered bankrupt by strife in our temples of education. Mental over-strain, when enforced day after day, soon renders the nerve structure incapable of absorbing adequate nourishment from the blood stream. Ultimately, nervous vitality is almost completely exhausted and depression, gloom, languor and mental impotence ensue. As the taxation is extended, the condition grows worse until anemia, anorexia, insomnia, melancholia, and perhaps, hysteria develop. Inasmuch as it is not within the power of the physician to remedy this evil system of handling our young women, it remains for him to evolve means of attenuating, as far as possible, the injury done, and preventing the development of lasting diseases which have their origin in the shattered nervous system. This is best accomplished by the upbuilding of the psychical and physical resources of the individual. Not by the employment of stimulants which act, ephemerally upon the organism, but by encouraging functional activity to its maximum degree consistent of course with normality. Obviously, this must be done by maintaining the entire digestive system at its proper standard, for it is through these channels that vital force is obtained and the well being of the economy is preserved. It is not consistent with logic to achieve this end by resort to the employment of those agents which relieve the digestive secretions of their special provinces. On the contrary, it is the very extreme of indiscretion to encourage dependency of the gastric or intestinal fluids, or to aid them in the performance of their duties beyond very circumscribed limits. Quite the most rational course to pursue is that of extending to Nature gentle, but ample, encouragement through the administration of an agent which is capable of bringing functional activity to its highest point without entailing the necessity of prolonged drugging. It is supremely important that the drug be one that can be withdrawn without leaving the economy disqualified to maintain a normal fund of force. It is here that iron is of the greatest therapeutic use. Not only does it impart to the blood stream a full measure of nutrition-conveyors in the form of hemoglobin, but it substantially increases the capacity of the tissues to absorb and utilize the nourishment placed at their disposal by the circulatory system. Further, iron, when administered in the proper form, augments functional activity throughout the entire digestive apparatus, and, thuswise, enables the economy to secure the full benefit of the food supply. To this action of the drug is due the greatest profit to the individual resulting from its use. The objections applicable to some forms of iron gain added importance in this particular class of cases, for the reason that the peculiarities of the disorders under consideration are such as to be greatly aggravated by an improper form of iron. Chief among these peculiarities is constipation, which is invariably a disturbing factor. The existing constipation is easily made worse by both the carbonate and acid solutions of iron; and, in fact these forms of the drug are notably stool-discouraging. Digestive processes are also depressed by these forms of iron, and headache frequently follows their use. Partly because of these objections, but mainly an account of its manifold advantages, pepto-mangan (Gude) is given the preference over all other forms of iron, and a mass of clinical data has been brought forth to sustain this opinion. Pepto-Mangan (Gude) is of the greatest aid in the treatment of all the ill-defined disorders commonly encountered among school-girls who exhibit a tendency to anemia, nervous debility, anorexia,moroseness and mental depression. Obviously, this general emphatic endorsement of pepto-mangan (Gude) by the most exacting members of the profession is based upon a critical analysis of its therapeutic advantages over the ancient forms of iron.

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