is small and the action therefore mild. The author thinks that the poisons circulating in the blood of the phthisical are in this way made inert. He mostly gives two to three grams in the day in two doses; in cases where no result is apparent he proceeds slowly to six grams. He has seen striking improvement in some advanced cases of phthisis. The appetite is increased, and the assimilation of food promoted. Details are given of six cases, some of which were advanced when they first came under observation two to four years ago. Guaiacol carbonate is practically useless in acute miliary tuberculosis.-British Medical Journal.

A REMARKABLe Bullet WoUND.-At a recent meeting of the Royal Society of Physicians of Vienna, Zemann (Weiner medizinische Blätter) presented the spinal column and liver from a boy, fifteen years old, who died of septicemia nine months after attempting suicide by shooting. The bullet had passed through the left lobe of the liver and the body of the eleventh dorsal vertebra, and between the vena cava and the aorta, without injury to either of the latter. The original injury to the liver had entirely healed, but the projectile had gained entrance into the vertebral canal, causing compression of the cord.

STATUE TO MARION SIMS IN NEW YORK.-Following the American custom, the monument has been erected entirely by private subscription. Scarcely any of the representatives of the city of New York took the trouble to be present at the ceremony of the unveiling. This was indeed very "Yankee." On the pedestal there is inscribed, among other things, this phrase: "He received the decorations of the French, Portugese, Spanish, Belgian, and Italian Governments." All those who know the United States will understand what these simple words are intended to say.-Le Progrès Medical.

THE PITHECANTHROPUS.-M. Duval comments on the discovery in Batavia of this missing link, this man-ape, by Mr. Eugene Dubois, military surgeon from the Netherlands. It is the so-ardently-desired intermediary between the anthropoid and man, and approaches very nearly the primitive Australian type. M. Duval considers this discovery the most important that has been presented to the Anthropological Society since its foundation.

PULSATING SARCOMA OF BONES.-Prof. E. Albert, of Vienna, reports three cases of pulsating sarcoma of bones; all three occurred on the left side and in old people. The upper end of humerus was affected in one case, upper end of tibia once, and the ischium once. A point of chief interest is the diagnosis from aneurism. All three cases were rapidly fatal, with formation of metastases.

CHLORHYDRATE OF PHENOCOLL.-M. Riber shows this preparation to be antimalarial. A crystalline powder, white, neutral, very soluble, of a sweetish, salty taste, easy to mask; it is powerfully antifebrile and anti

neuralgic, although at the same time absolutely innocuous. The dose is about thirty grains, administered three to five hours before the expected attack.

POISONING BY Water Gas.—Cases of poisoning by illuminating gas of more or less severity have been rather frequent in Boston this winter. People should not forget that water gas is more poisonous and has less odor than coal gas, that all gas furnished in this neighborhood now is water gas, and that especial precautions should be taken in consequence.

PROF. Naunyn, in Strasbourg, reports a case of cirrhosis of liver in a man aged twenty-five years. The patient had been in the habit for some years of drinking daily about six liters of beer, though he denied having drunk wine or whisky.- Weiner Klinische Rundschau.

TUBERCULOSIS IN CATTLE.-M. Nocard presents a series of memoirs showing particulary: (1) That the origin of tuberculosis in cattle is always by contagion, never by inheritance. (2) That injections of tuberculin have a distinct value in making an early diagnosis.

DR. WILLIAM OSLER, of Baltimore, authorizes the statement that he has not accepted the principalship of McGill University, and that he has no intention whatever of leaving the Johns Hopkins University.

PRIMARY SYPHILITIC CHANcre of Eyelid.-M. Danlos (Jour. de Med. de Paris) reports the case, lower eyelid being the site of initial lesion; mode of contamination was unknown.

Special Notices.

DR. CHAUNCY STEWART, of Alleghany City, Pa., has used IODIA very extensively in his practice, and regards it as the “ideal alterative-the sine qua non in the treatment of syphilis, scrofula, and all diseases arising from syphilitic contamination or a strumous diathesis. IODIA has this advantage over mercurial treatment in syphilis : when the patient does get well, HE IS WELL. He is not tortured with mercurial rheumatism nor made to blush through the syphilitic blossoming of his face in after years. HE IS WELL. Unlike the long-continued use of other alteratives, IODIA does not reduce and debilitate the constitution, but invigorates and restores the vital powers and enables the patient at all times to continue in the discharge of his vocation.

DR. LAWRENCE, in an article on “Diseases of the Skin—How to Treat Them," says: Eczema is an acute, non-contagious inflammation of the skin, characterized either by an erythematous papular, vesicular, or pustular eruption, or a combination of these, accompanied with burning, itching, and more or less infiltration, terminating either in discharge with the formation of crusts, or in desquamation. I have used PINEOLINE, a preparation of the ethereal extract of Pinus Pumilio, in all stages of this very annoying and troublesome cutaneous eruption with the most gratifying success. The itching and burning, which are among the more prominent subjective symptoms, are very quickly and permanently allayed. In the exudative stage and in the stage of

exfoliation following, it is a most admirable local application when the skin is infiltrated and thickened; and where there is a tendency to fissures, no preparation that I have ever used so rapidly reduced these and returned the parts to a healthy condition as does PINEOLINE. In eczema of nervo-bilious subjects the symptoms are usually irritable; in scrofulous individuals they run speedily and freely to the formation of pus, while in gouty subjects they are apt to be inflammatory. In all of these varieties, taking into consideration the temperament and idiosyncrasy of the patient, you will never be disappointed by this ointment.

SANMETTO IN Diseases of the Bladder and KidnEY.-To whom it may concern: I have been in the practice of medicine for the past forty-four years, and say without hesitation that I have never prescribed any remedy that in its action is so near a specific in diseases of the bladder and kidney as SANMETTO, and particularly in cases of urethral inflammation combined with difficult micturition. Much might be said truthfully in favor of SANMETTO in all diseases of the genito-urinary organs. I think it is THE remedy for those diseases, and the best now in use.

EAST LYME, CONN.

D. CALKINS, M. D.

DR. CHARLES DAY, M. R. C. S., etc., 79 St. Mark's Square, West Hackney, London, writes on January 17, 1893: I have prescribed your preparation, IODIA, with very satisfactory results. Its power of arresting discharges was very manifest in a case of leucorrhea, and another of otorrhea. In the latter case the result of scarlet fever in early life, the discharge had existed for many years. The patient could distinctly feel the action of the IODIA on the part, and the discharge gradually dried up.

DIPHTHERIA ANTITOXIN (BEHRING).—Schulze-Berge & Koechl, 79 Murray Street, New York, are the sole agents in the United States for the Farbwerke vorm. Meister Lucius & Brüning. Hoechst-on-Main, Germany, who manufacture Diphtheria Antitoxin (Behring) under the immediate supervision of Professors Behring and Ehrlich. They are assured of a regular supply of this product in the near future, and will soon be able to fill all orders for the same.

I AM using Phytoline (Walker) on a lady, who nine weeks ago weighed two hundred and fourteen pounds; was weighed last week and had lost twenty-nine pounds, weighing only one hundred and eighty-five. She is much pleased with the medicine, and will continue until her weight is less than one hundred and sixty pounds. BREAKABEEN, N. Y.

J. H. WECKEL, M. D.

LABOR SAVING: The American Medical Publishers' Association is prepared to furnish carefully revised lists, set by the Mergenthaler Linotype Machine, and printed upon either plain or adhesive paper, for use in addressing wrappers, envelopes, postal cards, etc., as follows:

List No. I contains the name and address of all reputable advertisers in the United States who use medical and pharmaceutical publications, including many new customers just entering the field. Price, $1.25 per dozen sheets.

List No. 2 contains the address of all publications devoted to Medicine, Surgery, Pharmacy, Microscopy, and allied sciences, throughout the United States and Canada, revised and corrected to date. Price, $1.25 per dozen sheets.

The above lists are furnished gummed, in strip form, for use un the "Plymouth Rock"* mailer, and will be found a great convenience in sending out advertising matter, sample copies, and your exchanges. If you do not use a mailing machine, these lists can readily be cut apart and applied as quickly as postage stamps, insuring accuracy in delivery and saving your office help valuable time.

Send for copy of By-laws and Monthly Bulletin. These lists will be furnished free of charge to members of the Association. See "Association Notes" in The Medical Herald. CHARLES WOOD FASSETT, Secretary, corner Sixth and Charles streets, St. Joseph, Missouri.

Certainly it is excellent discipline for an author to feel that he must say all he has to say in the fewest possible words, or his reader is sure to skip them; and in the plainest possible words, or his reader will certainly misunderstand them. Generally, also, a downright fact may be told in a plain way; and we want downright facts at present more than any thing else.—RUSKIN.

Original Articles.

SALOPHEN IN ACUTE RHEUMATIC AFFECTIONS.

BY H. A. RICHY, M. D.

There is no disease that is probably met more frequently by the general practitioner in New York than rheumatism, and if the physician succeeds in relieving the pains and fever in a short time, it will invariably earn him the gratitude of the suffering patient.

A great many drugs have been used in the treatment of rheumatism with more or less success, and in many cases the disease has proved refractory to treatment. It may be said that the first satisfactory results were obtained about twenty years ago through the administration of the salicylic acid compounds. In this country the drug most frequently used is the salicylate of soda, and a great many cases of rheumatism have yielded to the intelligent use of this drug. Some observers believe that relapses are more frequent when the salicylic acid compounds are used. Others object to their administration on account of the unpleasant symptoms which are liable to result from large doses of sodium salicylate, symptoms which in some cases compel the physician to give up its administration and resort to other kinds of treatment. Some years ago, when compelled to stop the use of salicylates, I tried antipyrine, phenacetine, and salol. Sometimes I obtained good results, but as a rule the treatment by means of the antipyretics afforded only momentary improvement, and they had to be discontinued. When salophen was first introduced into therapeutics, I read such satisfactory

accounts of its effects in rheumatism that I lost no time in trying this new drug, and my observations enable me to corroborate the favorable testimony of early observers. At the present time I have substituted salophen for all other antirheumatic remedies, except, possibly, in some cases of rheumatic tonsillitis, especially in children, where I still employ small doses of sodium salicylate.

From a considerable number of cases of rheumatism recorded in my books, I selected at random a few of the most interesting among the acute and subacute cases.

CASE I. Subacute rheumatism. Mrs. M. J., a German, sixty-four years of age, no previous history of rheumatism, and has enjoyed good health. In August, 1893, she complained of severe pains and stiffness in the right shoulder joint, and used liniments for several days. As the swelling extended up to the neck, she sent for me on September 2, 1893. On examination I found the shoulder joint almost immovable, the muscles over the upper part of the scapula tender and congested, with fever of 100.5°. No other disturbance; urine almost normal. Ordered salophen in fifteen-grain doses every two and a half hours. September 3d, swelling gone, pains absent except when the patient tried to move the arm; appetite good; no dizziness nor any stomach disturbances from the drug; temperature 99.5°. Ordered the dose of salophen to be reduced to ten grains every three hours. Patient preferred to take the salophen on the tongue, as it is tasteless. After five days patient was discharged from treatment; a little stiffness in the capsule of the shoulder remained for some time.

CASE 2. Acute articular rheumatism. J. T., a wood carver by trade, a Frenchman, accustomed to drink red wine and brandy, but never to excess, when first seen had a severe attack of tonsillitis with light pains all over the body. Was treated for ordinary sore throat with cough mixtures and gargles. On the fifth day, February 6, 1895, I was called by the wife of the patient who was very anxious. I found him stretched like a log in bed; every limb painful and swollen; lungs congested; tonsils swollen; no pericarditis. Fever of 104°; urine loaded with uric acid. Ordered salophen in fifteen-grain doses every two hours.

February 7th, found the patient very much improved, no disturbance produced by the drug. Reduced its administration to every three hours; temperature 101.5°; urine not so red. February 8th, patient had slept well, but had not taken any salophen for twelve hours, and was found by me in as bad a condition as on the 6th. Prescribed fifteen