THE MALTINE COMPANY offers A FIRST PRIZE OF One Thousand Dollars IN CASH A SECOND PRIZE OF Five Hundred Dollars IN CASH FOR THE BEST ESSAYS ON PREVENTIVE MEDICINE JUDGES. DANIEL LEWIS, A.M., M.D., New York, President of the New York State Board of Health; Professor of Special Surgery, New York Post-Graduate Medical School; Surgeon to the Skin and Cancer Hospital; Editor of “The Medical Review of Reviews.” CHARLES A. L. REED, A.M., M.D., Cincinnati, Ex-President American Medical Association; Ex-President American Association of Obstetricians and Gynaecologists; Fellow British Gynaecological Society. JOHN EDWIN RHODES, A.M., M.D., Chicago, Associate Professor Diseases of the Chest, Throat and Nose, Rush Medical College; Former Professor of Physical Diagnosis and Clinical Medicine, Northwestern University Woman's Medical College. Extract from Conditions which govern the Competition: "In order that there may be no violation of medical ethics and no suspicion of mere commercialism on our part, Maltine or any of its combinations must not be mentioned or even indirectly alluded to in the essays.” For full particulars address: THE MALTINE COMPANY 8th Ave. and 18th St., Brooklyn, N. Y. VITALITY The ESSENCE OF LIFE is the Blood. The Vital Element of the blood is Hæmoglobin. Without a normal percentage of this elementary principle the tissues are insufficiently oxygenated and poorly nourished. With a proper proportion the vital functions are quickened and the entire system thoroughly fortified. "Pepto-Mangan ("Gude") is a hæmoglobin producer, because of the quickly assimilable Organic Iron and Manganese which it contributes to the devitalized circulatory fluid existing in cases of Anæmia, Chlorosis, Amenorrhea, Dysmenorrhoea, Bright's Disease, Chorea, etc. Prescribe PEPTO-MANGAN "GUDE" in original bottles containing 3 xi. IT'S NEVER SOLD IN BULK. LABORATORY: M. J. BREITENBACH COMPANY. Sole Agents for Lited States and Canada, LEIPZIG, GERMANY. WARREN ST., NEW YORK. To Prevent Bursting of H, O2 Solution Bottles Automatic Safety Valve Stopper Patented by Charles Marchand Refer to National Druggist, of St. Louis, Mo., April, 1901 NO WIRE NO BURSTING HYDROZONE NO LOUD POPPING (Yields 30 times its own volume of active oxygennear to the condition of "OZONE") HARMLESS, POWERFUL BACTERICIDE AND PUS DESTROYER GLYCOZONE 买然 (C. P. Glycerine combined with ozone) HARMLESS AND MOST POWERFUL HEALING AGENT Successfully used in the treatment of Diseases of the Nose, Throat, MARCHAND'S EYE BALSAM CURES QUICKLY ALL INFLAMMATORY AND CONTAGIOUS DISEASES OF THE EYES Send for free 310-page book, 16th edition-" Rational Treatment of Physicians remitting 50 cents will receive, express charges prepaid, one complimentary sample of each, "Hydrozone" and "Glycozone." HYDROZONE is put up only in extra small, small, medium and large size bottles bearing a red label, white letters, gold and blue border, with my signature. GLYCOZONE is put up only in 4-oz., 8-oz. and 16-oz. bottles bearing a yellow label, red and blue border, with my signature. Bold by Leading Druggists Avoid Imitations PREPARED ONLY BY Charles Marchand Chemist and Graduate of the "Ecole Centrale des Arts et Manufactures de Paris" (France) 57-59 PRINCE STREET, NEW YORK THE BEST RE-CONSTRUCTIVE Phillips' Phospho-Muriate of Quinine, Comp. (The Soluble Phosphates, with Muriate of Quinine, Iron and Strychnia.) Permanent-Will not disappoint. PHILLIPS' Only, is Genuine. THE CHAS. H. PHILLIPS' CHEMICAL CO., NEW YORK. THE SOUTHERN PRACTITIONER. AN INDEPENDENT MONTHLY JOURNAL, DEVOTED TO MEDICINE AND SURGERY. SUBSCRIPTION PRICE, ONE Dollar Per Year. DEERING J. ROBERTS, M.D., Vol. XXIV. Editor and Proprietor. Original Communications. THE ETIOLOGY AND PATHOLOGY OF MALIGNANT TUMORS.* BY WILLIAM KRAUSS, M.D., MEMPHIS, TENN. This subject is entirely too great to be handled successfully in a ten-minute paper, and it will be necessary to confine ourselves to a very few points in the most recent literature, which is becoming daily more voluminous. Unfortunately, investigators in the parasitology and transmissibility of malignant tumors have arrived at some very contradictory results, and their claims are met by the adherents of the autogenetic theory by citing the very facts upon which the parasitologists lean. Andrews has collected 7,881 cases of primary carcinoma, all of which were upon exposed surfacesi. e., subject to infection; but it might be claimed by the irritationists that this is the best evidence of their mechanical (traumatic) origin. Briefly, all the arguments of the one side may be *Read before the Medical Society of the State of Tennessee, at Memphis, April 9, 1902. used by the other-viz., physiologic resistance, heredity, location, trauma, locus minoris resistentiæ, homologous character of cells, etc. Among the most noteworthy recent works of the parasitologists the foremost is the very classic article by Gaylord in the June (1901) number of the American Journal of the Medical Sciences. What has struck the present speaker most forcibly is the apparent harmonizing of the most discordant points of other investigators, as shown by a profusion of most perfect photomicrographs, showing bodies very like some I have photographed from section in stock in my private collection. Gaylord makes the statement that carcinoma is a parasitic disease due to a protozoon which he has found in all cases of cancer examined by his method, and reproduced the same therewith in experiment animals. Hekton, who in a review of the progress of pathology in Progressive Medicine in March, 1902, briefly alludes to all recent observations made in this line, says the whole structure of Gaylord crumbles because he has failed to cultivate the organism artificially and made his inoculation with an unfiltered ascitic fluid which might have contained proliferating epithelia. I think Hekton's critique too severe, because Gaylord specifically states that he used the sedimented fluid, and his photomicrographs seem to show that the carcinoma in the lung of his guinea pig is derived from the epithelia of the bronchi and air sacs, and is, therefore, homologous to the guinea pig, and not to the man from whom the fluid was taken. This is the strongest refutation of the autogenetic theory, for the favorite peg upon which the autogenetists have hung their arguments is that metastases were of cells homologous to the original site. The bodies (protozoa) were also found in the blood, spleen, and enlarged lymph glands of the experiment animals; and Gaylord is certain that the young forms of his parasite are identical in morphology and tingibility with Plimmer's bodies and Russell's fuchsine bodies, and he further shows that this is only a stage in the development of the parasite, which seems to explain why these were not uniformly present in all carcinomata. Schüller's parasites are said by Gaylord to be identical with his also. Gaylord is not the discoverer of this protozoön. Virchow long ago called attention to bodies in cancer cells analogous to the protozoa in molluscum contagiosum, the physaliphora. Pfeiffer, in 1888, found protozoa, sporozoa, and microsporidia in a case of carcinosis. One of the strongest arguments made against the etio |