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unattended with depressant effects. And most important to observe, it causes no drug habit, and does not, like opium, wreck the patient's mind while he is made oblivious of pain. Febrisol Liquid relieves the pain by reducing the inflammation, which is the cause thereof. It sets the circulation at rest by calming the nerve centers in the medulla, and through its influence upon the vaso-motor nerves it opens the flood gates of the skin, producing gentle perspiration, and thus cools the blood.

Experience amply shows that there is no more safe, efficient, thoroughly reliable remedy in such conditions than Febrisol Liquid (Tilden's).

COUGH AND RESTLESSNESS IN PNEUMONIA.-Dr. W. J. Parker truthfully states in the January Medical World that "the season for pneumonia is here," and it may be of interest to our readers to know that he has found an excellent remedy for the cough and restlessness which are such distressing symptoms of this dreadful malady in antikamnia and heroin tablets. Each of these tablets contain five grains of antikamnia and onetwelfth grain heroin hydrochloride, and the dosage is one tablet every two or three hours according to the exigencies of the case, or at the discretion of the attending physician. We may also add that Prof. Uriel S. Boone, of the College of Physicians and Surgeons, St. Louis, also reports most satisfactorily results with this remedy in pneumonia, bronchitis, and la grippe, particularly in relieving the accompanying spasmodic coughs and muscular pain.

TYREE'S ANTISEPTIC VERSUS BICHLORIDE, CARBOLIC, ETC. NONE of the objections to corrosive sublimate, carbolic acid, and other agents of this class-namely, toxicity, chemical union with albumin, superficial effect only, change to inert compounds, corrosive action upon tissues, harm to metal instruments, injury to the hands, etc.-prominent in medical literature are experienced in the use of Tyree's Antiseptic Powder.

"MANY a man is to-day worrying over a case or two of pneumonia, pleurisy, or capillary bronchitis, whose troubles would flit away like mist did he but know enough to put his patient into a jacket of antiphlogistine."-Medical Summary, November, 1902.

CHRONIC CYSTITIS.

S. C. SMITH, M.D., Henderson, Ky., says: "I am much pleased and somewhat surprised at the remarkably good effect Satyria is having in a female patient with chronic cystitis and incontinence of urine."

Two GOOD ONES.-For the past twenty-five years the Tongaline Preparations have been regarded by the medical profession as the standard remedy for rheumatism, neuralgia, grip, nervous headache, gout, sciatica, lumbago, etc., which of itself is the strongest testimonial to their wonderful intrinsic merits.

Ponca Compound, a uterine alterative, relieves congestions, encourages peristalsis, removes spasmodic conditions, and regulates the vascular supply, being invaluable in all uterine and ovarian functional troubles.

I HAVE used more or less of the two elegant preparations, Peacock's Bromides and Chionia, during the last two or three years, and must say with very satisfactory results. B. A. BоBB, M.D.

Mitchell, S. D.

I HAVE Used Seng and Cactina Pillets in my practice and find that they are all that has been claimed for them. Seng is excellent in those forms of indigestion following chronic catarrh of the stomach and bowels. I like the effect of Cactina Pillets in weak heart. I have used it for the last seven years. A. M. ARMSTRONG, M.D.

Crawford, Tex.

Selections.

SUPPURATING APPENDICITIS OPENING INTO THE BLADder. Juan G., a Spanish merchant, 37 years old, with evident syphi litic antecedents, began to suffer about two months ago acute pains in the right iliac pit, while a tumefaction was observed in that region.

He became an inmate of a clinic of this city, where his case was diagnosed as malignant neoplasm. After remaining about twenty days in said clinic, the patient decided to leave for Spain; in the meantime, he stopped at a hotel here. While there he was taken with violent fever and ague, with a temperature of about 41 degrees C., and the first micturition following this attack did show the presence of a great quantity of

pus.

Dr. Parra, who was attending the patient, did me the honor to ask me to assist him. I called on him the night after the evacuation of pus had occurred.

The first symptom to which my attention was called upon examination was the dimension and hardness of the liver, with

swellings, the massiveness of which continued uninterruptedly in connection with the massiveness of the iliac pit, in which region (the right iliac pit) an accentuated muscular resistance was observed, though that region instead of being swollen presented a depression, at the bottom of which the rim of the hepatic gland could be felt by the hand. The temperature was 38 degrees, the pulse beat between 80 and 90, and the general condition of the patient was rather satisfactory.

The diagnosis offered no doubt in our opinion: Suppurating appendicitis with evacuation into the bladder (the urine which was shown to us was extremely fetid and mingled, and it did contain a large quantity of pus) and syphilitic cirrhosis of the liver.

We advised the patient to consent to be operated upon, which he did. On the following day an incision of about seven centimetres was made into the middle of the depression observed in the iliac pit. We rapidly reached a perfectly defined cavity, which contained a little pus mixed with mucosities. We washed out the cavity with hydrozone and plugged it with iodoform gauze. On the following day when we dressed the wound, upon careful examination of the cavity, we did not find any connection with the bladder, but we could extract the appendix, which was affected by faeces.

A complete cure was accomplished in a month, and during that time the liver decreased considerably in volume. Since the third day of the operation anti-syphilitic treatment was followed.

The communication between the cavity of the abscess and the bladder healed after twelve days of treatment.-Dr. Enrique Fortun in Revista Medica Cubana, July, 1903.

CHILBLAINS to many will appear a trifling matter, but as one whose school days in winter were rendered miserable by them, I can assert that they are most maddening. Last winter my daughter, aged 11, suffered from them severely. Each time antiphlogistine was applied, the redness and intolerable itching disappeared in a night. I have tried remedies innumerable with no such result.

Pleurisy: Dr. Colin Campbell, Southport, Eng., L. C. R. P., M. C. R. S., writes in the Medical Press and Circular, London, Eng., Oct. 7, 1903:

Dr. B. was under my care last winter, suffering from a pulmonary cavity. He had had previously two or three intercur rent attacks of pleurisy, which I again found present on Dec. 7, 1902, accompanied by severe pain over the cavity, and a temperature of 103 degrees. His previous attacks had occurred at his home, where careful poulticing was practicable, but in apartments this was unsatisfactory, and so it occurred to me to try antiphlogistine.

The material was warmed and "troweled" on for many inches around the pleuritic center, then covered with non-absorbent lint and Jaconet.

The result was remarkable; the pain disappeared within an hour, and the high temperature within two days.

Many advantages over poulticing were noticed by the patient; facility of application, no unendurable heat, rapid relief from pain, its adhesiveness rendered movement possible without tight bandaging or the alternative sudden influx of cold air which follows the separation of a poultice from the skin.

DEPRESSANT DRUGS AND Sudden DeatнS.-It is very interesting to examine the statistics of sudden death from heart disease in New York City during the last three years. In 1900 there were registered 4,069 deaths from heart disease in the Greater City of New York in a population of approximately 3,445,000, while in 1901 there were 4,626 such deaths, the population having presumably increased about 100,000. Thus there was an increased ratio of sudden deaths to population. In 1902 the number of sudden deaths reported from heart dis ease had increased still further to 5,461. Calculating the percentages of sudden deaths from heart disease to population, allowing for the before-mentioned increase of population, the deaths of this kind to each thousand were, in 1900, 1.18; in 1901, 1.31; in 1902, 1.34.

For the year 1903 there was a decrease in the number of deaths from this cause, so that the ratio was only 1.28 per thousand. There has been some discussion among sanitarians and public-health officials as to the reason for this decrease.

A portion of the decrease has been ascribed definitely-and with considerable plausibility-to a certain cause. At the beginning of last year the Board of Health, suspecting that many prescriptions for phenacetin were being filled by druggists with acetanilid, or with a mixture of phenacetin and acetanilid, sent inspectors to obtain definite information on this matter. Altogether 373 samples of phenacetin were bought from the same number of drug stores in various parts of the city, phenacetin being specially asked for and in some instances even obtained, on a physician's prescription. Of the 373 samples, 58 were pure phenacetin, 315 were adulterated with cheaper drugs, mainly acetanilid, and in 267 cases containing more acetanilid than phenacetin; 32 samples were pure acetanilid. The commissioner made these facts public, and threatened to expose and prosecute all druggists who would hereafter be found committing this misdemeanor.

It is very interesting at least to find that a single year after the investigation and supposed consequent reform on the part of the dispensing pharmacists, there should be a slight reduction in the actual sudden death rate from heart disease, and that at a time when for many years there has been a constant increase in the death rate from this cause. It is well known that acetanilid is a distinctly depressant drug for the heart. Prof. Jacobi, of New York, always insists that it is an actual tissue poison, to be used only with great care, and many therapeutists teaching that it is the underlying cause for the increase in reported sudden deaths that has occurred in recent years.

This question of the evil of depressant drugs is all the more interesting because of the freedom with which so-called headache powders, mainly composed of acetanilid and other heartdepressants, are now so commonly bought and sold. Many women, and even men, think nothing of stepping into a drug store and asking for something for a headache. The headache powders that are dispensed to them so freely always contain acetanilid, and great harm is being done in this way. It is probable that a similar investigation in other cities of the country might also furnish instructive facts. Certain it is that proper legal regulation of the sale of such depressant drugs, so that they could not be dispensed except under the direction of a competent physician, would in the long run have a beneficial effect on the sudden death rate from heart disease.

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