and die from large doses, a whole train of startling symptoms preceding the fatality, e. g., hypothermia, genital excitation, ejaculation, tremors and paralysis. Thus physiological experiment confirms the long recognized potency of ovarian influence on man. Man has been the recorded victim of psychical toxicity of ovarian origin from time memorial but the potently poisonous power, intoxicating and paralyzing, of the ovary, is now proven beyond peradventure by these late researches of Ferré and Bestion.

The American Gynaecological and Obstetrical Journal for August, 1898, contained an important editorial entitled, "The American Medical Press." We think this editorial is in accord with the sentiments of all who would wish well for the medical profession. The editor, Dr. Emmett says: "The value of the press to us lies in its control, its universal and absolute control, by ourselves, by medical men who are bound by professional obligations, by that common interest which binds us all," and in the proper support of medically owned and conducted journals by medical men to the exclusion of all others. We are in hearty accord with Dr. Emmet.

The Answer of Professor E. Behring to his Critics.-The answer of Professor Behring to his critics. in the Deutsche medicinische Wochenschrift of September 15th relative to the patent which the Washington authorities have recently granted him for his diphtheriaantitoxin does not answer their arraignment satisfactorily and the Philadelphia Medical Journal sits down on the commercial and avaricious professor in a well-merited manner. Behring claims to be beyond criticism because he has gone without the pale .of the profession.

Micro-organism and Portal Cirrhosis.-The Montreal Medical Journal contains a preliminary communication by J. G. Adami, Professor of Pathology in McGill University, Montreal, "Upon the Existence of a Minute Micro-organism Associated with Cases of Progressive Portal Cirrhosis." This is a most important discovery likely to lead to an entirely new view regarding the aetiology and pathology of fibrosis in general. A complete account of his discovery appeared in the August number of the Montreal Medical Journal.

Dr. Alex. L. Hodgdon, of Baltimore, has recently been elected to the Chair of Nervous Diseases and Diseases of the Mind of the Maryland Medical College.

Langsdale's Lancet has gone into other hands, and although a lively publication under Langsdale's management it will not languish under the new regime. Henceforth it will appear as the Kansas City Lancet, edited by Dr. John Punton and three other Kansas City doctors, who each and all can thrust the lance of medical literary criticism with discernment and skill. And the Kansas City Lancet will cut medical error and folly as keenly as ever.

The Peacock Chemical Company of St. Louis, Mo., patriotically announces to its customers that it will. stamp its goods without raising its price to the retailer or

consumer.

IN MEMORIAM.

DR. WILLIAM PEPPER, professor of the Principles and Practice of Medicine and of Clinical Medicine, and late provost in the University of Pennsylvania, died suddenly on July 28, 1898, at Pleasanton, California, where he had gone for rest from the multiplicity of tasks and responsibilities with which he had so long labored. His sudden demise is mourned, not only in the immediate circles in which his activities were most intimately known, but beyond those limits far and wide there is a feeling of public bereavement and a disposition to pay an appropriate tribute to his career.

Dr. Pepper was born in Philadelphia on August 21, 1843, the son of the distinguished Dr. William Pepper, who occupied the chair of Theory and Practice of Medicine in the University from 1860 to 1864, and who died in October, 1864, in the 55th year of his age. The son was graduated from the College Department of the University in 1862, and from the Medical Department in 1864. After receiving his degree he devoted himself especially to the study of clinical medicine and pathology, and in 1868, when morbid anatomy was made a separate branch in the University, he was elected to the lectureship. In 1870 he became lecturer on Clinical Medicine, and this title he retained until 1876, when he was given that of professor of Clinical Medicine, which he held until 1884, when he succeeded Dr. Alfred Stillé in the chair of the Theory and Practice of Medicine. His ability as a teacher and clinician is well known. In 1881 he became provost of the University, which post he held for thirteen years. The progress which the institution made under his direction is without a parallel in the history of education in America.

In 1895, Dr. Pepper built and partially endowed the William Pepper Laboratory of Clinical Medicine as a memorial for his father.

To Dr. Pepper more than any one else belongs the credit of the impetus which has been given to higher medical education in this country, he having prompted the University to take the lead in establishing a four years' course of study.

Notwithstanding his exacting duties as administrator, organizer, practicing physician, and man of affairs, Dr. Pepper found time for a vast amount of literary work. In 1870 he founded the Medical Times. His most important works are: a "System of Medicine by American Authors," published in 1885-86; "Diseases of Children," written in collaboration with Dr. John F. Meigs; and the "American Text-Book of the Theory and Practice of Medicine," a large portion of which was contributed by Dr. Pepper himself.

To Dr. Pepper belongs the credit of establishing the system of commercial museums, which had as their nucleus a collection of fabrics and products obtained from foreign exhibitors at the World's Fair. It was his idea to have the Philadelphia commercial museums placed on a tract of land adjoining that occupied by the Museum of Science and Art of the University, so that there should be in one place a vast collection rivalling the far-famed South Kensington Museums, and making Philadelphia the art centre of the western hemisphere.

Other important educational movements owe their success very largely to the untiring devotion of Dr. Pepper, viz., the popular lecture courses at the University, the University Extension, and the Free Library of Philadelphia. The growth of the last has been phenomenal, and already its circulation is larger than any other library in the United States.

He was medical director of the Centennial Exposition in 1876, one of the founders of the Museum and School of Industrial Art, a member of the College of Physicians, American Philosophical Society and Academy of Natural Sciences, president of the Pan-American Medical Congress, and of the Commercial Museum.

In the death of Dr. Pepper the community has lost one of its foremost citizens and philanthropists, a skillful physician, a successful educator, and a leader in every enterprise that was intended to promote the common weal.

REVIEWS, BOOK NOTICES, ETC.

PRACTICAL URANALYSIS AND URINARY DIAGNOSIS. A Manual for the use of Physicians, Surgeons and Students. By Charles W. Purdy, M. D., LL.D., (Queen's University); Fellow of the Royal College of Physicians and Surgeons, Kingston; Professor of Clinical Medicine at the Chicago Post-Graduate Medical School. Author of "Bright's Disease and Allied Affections of the Kidneys;" also of "Diabetes: Its Causes, Symptoms, and Treatment." Fourth, Revised Edition. With Numerous Illustrations, including Photo-engravings and Colored Plates. In one Crown Octavo Volume, 365 pages, bound in Extra Cloth, $2.50 net. The F. A. Davis Co., Publishers, 1914-16 Cherry St., Philadelphia; 117 W. Forty-second St., New York City; 9 Lakeside Building, 218-220 S. Clark St., Chicago, Ill.

This is, as its title implies, a practical manual of Uranalysis and Diagnosis. And the author, Dr. Purdy, is well qualified for the task he has undertaken and has performed it well. The book will give the practicing physiclan satisfaction. The book is handsomely bound, and the text and illustrations are done in the attractive style of the well-known publishers. PRIMER OF PSYCHOLOGY AND MENTAL DISEASE. By C. B. Burr, M. D., Medical Director of Oak Grove Hospital for Nervous and Mental Diseases, Flint, Mich.

We acknowledge the receipt of this primer for use in training schools for attendants and nurses and in medical classes, which has reached its second edition, and can only reiterate the good opinion expressed in reviewing the first edition.

MEDICAL LIBRARIES. We have received No. 5-6, Vol. I, of this Journal, which is devoted to the Interests of Medical Libraries and Bibliography. C. D. Spivak, M. D., Editor, 3 Denison Building, Denver, Colorado. Price 50c Per Annum. Foreign Subscription, $1.

By Thomas S. Clouston,

CLINICAL LECTURES ON MENTAL DISEASES. M. D., Lecturer on Mental Diseases in the University of Edinburgh. New (5th) edition. Crown 8vo., 750 pages, with 19 full-page colored plates. Cloth, $4.25, net. Lea Brothers & Co., Publishers, Philadelphia and New York.

Clouston comes again with a fifth edition of his Clinical Lectures on Mental Diseases. A beautiful frontispiece showing the cortex of the brain in advanced general paralysis fronts the title page of this excellent book on