any giant cells, tubercle of lepra bacilli, and no evidence of cell inclusions was seen. As for the occurrence of such lesions in framboesia, and their distribution, little can be said excepting as quotations from authors who have had considerable experience with the disease. Manson says, in discussing the distribution of the yaws, that they may be scattered over the entire body, or the crop may be limited to one or two growths, or they may be confined to a circumscribed region of the skin. Moreover, there may be successive crops evolved, especially when the person affected is debilitated. Morris remarks that the disease in adults is more chronic than in children. When the yaw develops normally it does not ulcerate, but Manson says that the tumors instead of being absorbed, may break down and ulcerate, the ulceration usually being confined to the yaw itself, although it may go deeper and give rise to extensive sores. With the development of the deeper and more extensive forms of ulceration, the typical lesion of framboesia may disappear for a time, or perhaps permanently. If such is the case, the ulcerations are said not to be infective and to not communicate the disease, although they may persist for years. Nicholls, quoted by Mason, states that ulceration occurs in about 8 per cent of the cases. There is no histologic description of the variety of the lesion which I have encountered to which I can refer, though from Unna's and Charlouis's description of the typical yaw it is but a modification of the latter. These writers speak of the true yaw as a cutaneous plasmoma complicated by epithelial hyperplasia and hyperkeratosis. Except that the lesion described above is not raised it certainly corresponds in many details with Unna's and Charlouis's description. REFERENCES TO LITERATURE. MANSON. Tropical Diseases. London, 1903. MORRIS. Diseases of the Skin. Philadelphia, 1898. HYDE. UNNA. Hautkrankheiten. Berlin, 1894. SCHEUBE. Die Krankheiten der warmen Länder. Jena, 1900. SECTION STAINED WITH HEMATOXYLIN AND EOSIN. (ZEISS COMP. OC. 6, OBJ. A. A.) This shows the hyperplasia of the acanthus layer of the skin, the dilated blood vessels, and the perivascular accumulations of small round and plasma cells. Photomicrograph by Martin. PREVIOUS PUBLICATIONS OF THE BUREAU OF GOVERNMENT LABORATORIES. (Continued from second page of cover.) No. 22, 1904, Bureau of Government Laboratories.-I. A Description of the New Buildings of the Bureau of Government Laboratories. By Paul C. Freer, M. D., Ph. D. II. A Catalogue of the Library of the Bureau of Government Laboratories. By Mary Polk, Librarian. No. 23, 1904, Biological Laboratory.-Plague: Bacteriology, Morbid Anatomy, and Histopathology (including a consideration of insects as plague carriers). By Maximilian Herzog, M. D. No, 24, 1904, Biological Laboratory.-Glanders: Its Diagnosis and Prevention, together with a No. 26, 1904, Biological Laboratory.-The Clinical and Pathological Significance of Balantidium Coli. By Richard P. Strong, M. D. No. 27, 1904, Biological Laboratory, Botanical Division.-A Review of the Identifications of the Species Described in Blanco's Flora de Filipinas. By Elmer D. Merrill. Publications of the Bureau are given out in serial number pertaining to the entire Bureau. Publications which may be desired can be obtained by applying to the Librarian of the Bureau of Government Laboratories, Manila P. I., or to the Superintendent of Government Laboratories, Manila, P. I. |