Annual Reports in Medicinal Chemistry, Volume 37Annette M. Doherty Elsevier, 2002 M10 2 - 364 pages Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. |
Contents
Pathophysiology and Design of | 11 |
Paradigm Shift | 31 |
William J Greenlee ScheringPlough Research Institute | 41 |
Phosphodiesterase 5 Inhibitors | 53 |
Antagonists of VLA4 | 65 |
Purine and Pyrimidine Nucleotide P2 Receptors | 75 |
Inhibitors of the Factor Vila | 85 |
CANCER AND INFECTIOUS DISEASES | 95 |
Inhibitors of p38 MAP Kinase | 177 |
Janet M Allen Inpharmatica London United Kingdom | 187 |
Matrix Metalloproteinases and the Potential Therapeutic Role for Matrix | 209 |
New | 217 |
Tumor classification for tailored cancer therapy | 225 |
TOPICS IN DRUG DESIGN AND DISCOVERY | 237 |
MicrowaveAssisted Chemistry as a Tool for Drug Discovery | 247 |
TRENDS AND PERSPECTIVES | 257 |
The Chemistry and Biology of Tetracyclines | 105 |
Intracellular Signaling Targets for Cancer Chemosensitization | 115 |
Emerging Microtubule Stabilizing Agents for Cancer Chemotherapy | 125 |
Antiviral Agents | 133 |
Aerosol Delivery of Antibiotics | 149 |
IMMUNOLOGY ENDOCRINOLOGY AND METABOLIC DISEASES | 159 |
Selective Glucocorticoid Receptor Modulators | 167 |
Dynamic Modeling of Biological Systems | 279 |
| 289 | |
| 297 | |
| 315 | |
CUMULATIVE NCE INTRODUCTION INDEX 19832001 BY INDICATION | 331 |
Common terms and phrases
5-HT2c receptor Acad acid activity ADHD aerosol affinity agents agonists analog antagonists antibiotic antihypertensive antiinflammatory antineoplastic antiviral ARMC GENERIC NAME Aẞ assays associated binding Biochem Biol Bioorg biosimulation bosentan cancer CAS Registry cell cellular Chem Chen chronic Clin clinical trials complex compounds Curr cytokines derivatives disease domain dose drug effects efficacy Eletriptan enzyme epothilone FcyRlla function fVlla genetic genome human hydrochloride identified increased INDICATION INTRO infection inflammatory inhalation antibiotics inhibition interaction ion channels kinase Lett levels ligands membrane metabolic methylphenidate mice microwave MMPs modulators molecular Natl neurons novel NSAIDs OCH3 OH OH Opin oral Patent Applic pathway PCT Patent Appl PDE5 inhibitors peptide Pharmacol protein pulmonary hypertension recent reduced regulation REPORTS IN MEDICINAL role selective sildenafil sodium specific structure studies subtypes synthesis targets tenofovir tetracycline therapeutic therapy tissue transposon treatment trimegestone tumor vitro vivo Wang