is no doubt in my mind that the antiparasitic and antifermentative preparations are productive of the best results. Of the numerous preparations of this character that are now on the market, Listerine has by far the largest number of advocates, and I believe from quite a large experience with it, that it justly deserves the recognition and endorsement that the medical profession has so universally given it. Its therapeutic effects are dependent entirely upon its power to disinfect, so far as is possible, the alimentary E. C. Register, M. D., Charlotte, N. C.

LATENT RHEUMATIC CONDITIONS are now more prevalent on account of an exceedingly cold and damp spring, causing many recurrent cases of rheumatism, neuralgia, and grippe, for which Tongaline Liquid is the standard prescription.

WHAT SHALL IT BE? This question is present in the mind of the busy physician every summer when he confronts the problem of appropriate tonic medication for the weak, poorly-nourished, and debilitated. He knows that during no other season of the year is there so marked a tendency to disturbances of the gastro-intestinal tract, and that many intractable forms of diarrhea may result from unsuitable foods and medicines; the first requisite, therefore, is to select a tonic that has the negative virtue that it will not irritate the sensitive stomach and intestines. Cod liver oil, iron, and the usually employed nutritives and tonics have a well-defined local irritant action on the gastro-intestinal tract, and are unsuitable when these organs are in the super-sensitive condition so commonly present during the heated term; these remedies, experience proves, lack even the negative virtue of non-irritating character.

The next question to be decided is, what remedy has a selective action on the gastro-intestinal mucous membrane whereby its functions are kept in a normal condition? In other words, how may the natural tendency of hot weather to set up irritation of these organs be combated. and at the same time how can the patient be properly nourished? A moment's thought as to the physiologic efforts of Gray's Glycerine-Tonic Comp. will answer these questions, and explain why this remedy is the best tonic and reconstructive for summer use.

First of all, Gray's Tonic is one of the most prompt and reliable gastric sedatives known to the profession; as instance of this it is only necessary to recall its wide-spread use in the gastric irritability and vomiting of pregnancy and sea-sickness. Once having pacified the stomach. it exerts very positive effects upon the secretory and motor functions of this organ, manifested by creation of appetite and increased power to digest food. It is a great step forward when these patients can take sufficient quantities of proper food and have the power to digest and assimi

late it. Gray's Tonic accomplishes this, and as a consequence has a pronounced influence in improving the nutrition of the patient. It thus starts aright the complicated physiological processes which result in increased blood constituents, more vitality, greater strength, and increased power to resist the inroads of disease.

Let any one who doubts the truth of these statements try Gray's Tonic in any case of malnutrition, general debility, or nervous exhaustion existing independently or as a part of chronic organic diseases, and note how well these patients stand the depressing effects of hot weather, how free they are from gastro-intestinal complications, and how beneficial the remedy is upon the general nutrition.

Gray's Glycerine Tonic Comp. owes its distinctive value to the proportion of the contained ingredients and their manner of combination. All imitations lack these characteristics of the original, and are consequently of inferior value.

TONGALINE AND LITHIA TABLETS are particularly indicated in diseases which are caused by deposits of urates in the tissues, especially in the joints and in the kidneys.

A MOST POWERful, Eliminant.-Genoform is continually prescribed by physicians throughout the country in the different forms of rheumatism, neuralgia, grip, gout, sciatica, and lumbago. The most efficient and satisfactory results are obtained by the administration of this new remedy which, though only lately introduced to the medical profession, has demonstrated its full therapeutic value within a short time. We would suggest to our readers that they write to C. Bischoff & Co., of 88 Park Place, New York, the importers of Genoform, for literature pertaining to this very reliable remedy.

THE ANTISEPTIC TREATMENT OF THE SUMMER DIARRHEAS OF INFANTS.— Of the various agents that have been suggested for the disinfection of the intestinal tract, Acetozone is by far the most promising. It has been shown by Novy and Freer, of the University of Michigan, that Acetozone, even in weak solutions, destroys bacillus pyocyaneus, bacillus coli, bacillus typhosis, bacillus diphtheriæ, vibrio choleræ, staphylococcus pyogenes aureus, and streptococcus pyogenes in less than one minute. These writers say that "while the strong solution kills everything almost instantly, the weaker solution (1:3000) destroys the vegetating germs, as a rule. within one minute." At the same time solutions of 1 to 1000 strength are given internally without the least harmful effect. The good results accruing from the use of this remedy in the summer complaints of young children are early and unmistakable; the discoloration and putridity of the

stools disappear; the diarrhea is checked; the temperature falls; pain and inflammation subside; the vomiting is controlled; and the condition of anguish and irritability is consequently greatly dispelled.

In dealing with this class of cases, the following make up the round of treatment: (a) withdrawal of milk and the substitution of thin broths, albumen, and cereal waters, or other liquid feedings; (b) immediate evacuation of the stomach and intestines by stomach-washing and intestinal flushing with Acetozone solution (1:5000 or stronger); (c) the sustaining of the patient's vitality; (d) administration of an internal antiseptic - Acetozone (1:3000 to 1: 1000); (e) the observance of hygienic conditions. In giving the drug, the solution usually administered to adults (15 grains to the quart) should be diluted with one half its quantity of water and flavored with lemon or orange juice. It should be given in teaspoonful doses at frequent intervals — every twenty or thirty minutes in the beginning, lengthening the intervals as the case progresses.

Colonic irrigation is a useful procedure in cholera infantum. Acetozone (1:5000) solution is unexcelled for this purpose. The same solution may be used for lavage, which is recommended by many leading authorities. In washing out the stomach, the irrigating fluid invariably should be lukewarm, and is best introduced prior to the feedings. Its continuance must be based on the character of the washings.

Acetozone is marketed in ounce, half-ounce, and quarter-ounce vials. and in boxes containing six vials of 15 grains each. An ounce is sufficient to make eight gallons of aqueous solution.

TONGALINE AND LITHIA TABLETS can be prescribed with the greatest benefit for many people who indulge in generous or intemperate habits of living, as this combination will promptly and thoroughly eliminate any excess of uric acid in the system.

MENOPAUSE.

Preceding and succeeding the final cessation of ovulation and menstruation, physical and psychical disturbances of a more or less serious character are frequently observed. Ergoapiol (Smith), because of its tonic effect upon the female generative system, and its splendid antispasmodic influences, is of unsurpassed value in the treatment of the various disturbances incident to this period.

WORDS OF APPRECIATION.-The following letter, relating to the treatment of opium and other addictions, will interest many. It is addressed to our old friends, The Antikamnia Chemical Company, and reads:

"GENTLEMEN: Illness, dating from the very day of my former letter, must be my plea for my silence and my seeming indifference to your courtesy, and your exceptional kindness in sending me your little 'Vest

Pocket-Box.'

I want you to feel that I sincerely appreciate your goodness in this little matter. I am in charge of the Woolley Sanatorium, an institution conducted exclusively for the cure of opium and other drug addictions, and am using Antikamnia Tablets extensively after withdrawing morphia, and I am free to say that I do, in reality, regard your product as 'A Succedaneum for Morphia.'

"Our institution is probably the largest of its kind in the South, and if my views should prove of value to you at any time, command me, and use them as you wish. MARION T. Davis, M. D., ("Univ. of Maryland School of Medicine.)

"Atlanta, Ga., April 15, 1905."

AN UNUSUALLY COLD AND DAMP SPRING is always conducive to the development of much malaria, for which Tongaline and Quinine Tablets are almost a specific, Quinine for the fever, Tongaline for eliminating the poisonous secretions.

LOUISVILLE UNIVERSITY, MEDICAL DEPARTMENT.- Do not fail to read the advertisement of this most excellent medical school in this issue. This institution is the successor of grand "Old Transylvania," than which no school is entitled to such glorious memories. The mantles of those grand men who established the second medical school west of the Alleghanies have fallen on most worthy shoulders. The remarkable reputation of Transylvania has lost nothing at the hands of those who have controlled and are now controlling the destinies, the methods, and the cus toms of the Louisville University Medical Department. By all means write to Dr. Bodine.

INTESTINAL DISORDERS DUE TO LACK OF NORMAL INTESTINAL ALKALINES.― At this period of the year we are called upon to consider carefully the application of therapeutic measures to be adopted in the treatment of disease of the gastro-intestinal tract. Conditions met in these cases have a marked degree of similarity, due primarily to a faulty or altered secretion of intestinal juices, and secondarily through errors of diet, etc. The contents of the bowel are found to be made up of a fermenting mass of decomposed food, broken-down mucous membrane, together with fluids of intensely acid reaction loaded with pathogenic bacteria. The logical treatment indicated would call for a prompt removal of the source of infection and the restoration of normal secretion.

A prominent practitioner in the South, whose wide experience justifies authority, recently embodied in a paper the following statement: "In diseases of the intestinal tract in children or adults, whatever the diagnosis may be, we always trace the origin of the trouble to a want of alkalines

to correct an excess of acidity during the digestive process." This is of deep interest to us, as it gives the key to the marked results following the administration of the alkaline antiseptic, Glyco-Thymoline, which not only corrects existing hyperacidity with its concomitant symptoms, but causes by its exosmotic property a rapid depletion of the engorged membrane and a stimulation of the glandular system to normality, whereby the proper amount of alkaline fluids will be secreted. Therefore it is well to remember that Glyco-Thymoline not only corrects the effects of disease, but aims to re-establish those processes of digestion and assimilation which are wanting.

In severe cases of cholera infantum, dysentery, ileo-colitis, etc., the solution should be administered as a colon flush, using a 10 per cent. solution of about 100° F. This treatment, combined with 3 to 3ii doses per oram, serves rapidly to eliminate all toxins, promote an aseptic condition of the bowel, and to encourage what is most needed, the secretion of normal alkalines.

CARBUNCLES.-Creel has relied on Ecthol, given internally, in doses of a teaspoonful, in cases of carbuncles, flax-seed poultices applied locally, emptying of pus, scraping out of dead tissue, and cleansing with Peroxide of Hydrogen; after this, a topic application of Ecthol on absorbent cotton every four to eight hours. The average duration of this treatment in his cases was ten days.- Journal of the American Medical Association.

INCIPIENT INSANITY.- Dr. T. O. Wood, of London, England, writing in the current number of a prominent journal of the causes and cure of incipient insanity, concludes by saying. "While correcting the general health, our aim must be to allay prominent symptoms, and at the same time remove the special causes which underlie them. For insomnia, regular exercise, short of fatigue, and living as much as possible in the open air by day, with tepid baths for the neurasthenic, will greatly help us, and above all things, congenial physical occupation and rational amusements. Should want of sleep continue, and if there is early morning restlessness, then Daniel's Conct. Tinct. Passiflora Incarnata should be employed, because it nourishes the ganglia and allays nervousness, which in reality is the source of the disease."

Passiflora is the true nerve sedative and hypnotic, and is being prescribed by physicians who have discovered the many injurious narcotics and antispasmodics now in general use.

Passiflora is indispensable in the treatment of hysteria, insomnia, and convulsions, and gives the most satisfactory results with the nervousness of women and children.