sleep produced by it is natural and undisturbed by dreams; it has no injurious effect upon the appetite, circulation, respiration or temperature, and the general health does not suffer under its use. After a time the dose may be reduced, or it may be discontinued, and the patient still continue to sleep well. Dr. Johnstone also found that it had a distinct sedative action in mental excitement and distress, and could be employed with great benefit in cases of insanity, especially such as are of recent or acute character. Its complete tastelessness also is recommended in such cases allowing its combination with food, or in milk in such a way as to escape the notice of the patient. The chief drawbacks were found to be its slowness of action, and often the persistence of its soporific effect during the succeeding day, together with, at times, confusion, giddiness and fatigue. After repeated doses, a dreary confusion was noticeable, and subsequently slight weariness and fatigue, followed in a few days by enfeeblement and shakiness of motion, but nothing occurred which could be called an alarming symptom. As a rule, indeed, the mental condition improved, the excitement, irritability and motor restlessness being diminished and the wretchedness dispelled. It will thus be seen that the writer's conclusions are in accord with the majority of those already published, and that while regarding sulfonal as by no means a perfect hypnotic, he is inclined to give it a very important place in the treatment of sleeplessness and restlessness generally. The best doses he found to be between thirty and forty grains, and should be given just before the patient lies down. The freedom of the drug from taste or smell, as has been said, is one of its advantages, and renders its administration easy.

PHENACETIN AND OTHER ANTIPYRETICS.-The unexampled success of phenacetin, as a certain and safe antipyretic, has given rise to many clinical comparisons of that medicament with other febrifuges, but the results have served only to increase the reputation of phenacetin. Prof. Eickhorst, of Zurich, recently said (Schweiver-Aerste, No. 5, 1892): "I have no great partiality for new antipyretics, for, in my opinion, fever should only be combated in emergency cases, and for

this purpose some of the known antipyretics are amply sufficient. But if I should happen to find an antifebrile treatment necessary, I should certainly make use of phenacetin. Phenocol is an active antipyretic, but under its influence most of my patients transpired very profusely, and several suffered from rigors. The temperature soon rose again, and I found that the action of phenocol did not, in any, give so satisfactory an action as that obtained from phenacetin. As an antirheumatic, phenocol does not equal salicylic acid, and as an antineuralgic, it has not as yet proven particularly favorable, but it has been noticed that abdominal typhoid seems to take an easier course after its administration.

THE COMMITTEE appointed at the last meeting of the American Medical Association to consider the best means for promoting the prosperity of the sections of the Association, will hold an adjourned meeting in the Hotel Cadillæ, Detroit, Mich., June 6, at 3 P.M.

Members of the Committee are requested to notify the Chairman of their intention to be present at this meeting.

The Committee would esteem it a favor if each member of the Association would communicate in writing his or her views concerning the best measures for promoting the development of the sections. Such communications may be sent to the Chairman of the Committee. John S. Marshall, M.D., Chairman, 9 Jackson St., Chicago.

THE Hungarian State Health Commissioner, in a report to the Minister of the Interior (Pharm. Post, Vienna, No. 10-92), stated that in the treatment of influenza no specific was known, but each case required individual treatment. Concerning the use of antipyretics, such as antipyrin and phenacetin, it appeared that the latter especially gave good results, while a portion of the patients were less favorably affected by salipyrin.

MARRIED.-At Oak Grove, La., March 9th, at the residence of the bride's father, Dr. Joseph Grigsby of Floyd, La., to Miss M. A. Bradley.

THE Mississippi Valley Medical Association will hold its eighteenth annual session at Cincinnati, Wednesday, Thursday and Friday, October 12, 13 and 14, 1892. A large attendance and a valuable program are expected. Chas. A. L. Reed, M.D., President, Cincinnati. E. S. McKee, M.D., Secretary, Cincinnati.

PASTEUR INSTITUTE.-The second annual report of the New York Pasteur Institute has been received. The results of treatment have proven quite satisfactory. During this (the second) year 574 persons have been treated, and but three deaths from hydrophobia and three deaths from intercurrent diseases have occurred.

AN ERROR.-In our biography of Dr. J. W. Penn in the March issue of the MONTHLY, we stated that he had been the Vice-President of the West Tennessee Medical Society. The Doctor informs us that he was never connected with that organization.

BOOK NOTICES.

The medical books noticed under this heading can be procured at publisher's prices, from Messrs. YOUNG & BROTHER, 248 Main street, Memphis.

PRESCRIBER'S PHARMACOPEIA. A Synopsis of the more recent Remedies, Official and Unofficial, with a Therapeutic Index and a Resume of the B. P. Additions, 1890. By a member of the Pharmaceutical Society of Great Britain. Second edition (revised reprint). Kemp & Co., Ld., Wholesale and Manufacturing Chemists, Bombay.

This is indeed a remarkable little book, and coming as it does from "away off" India makes it even more wonderful to the average American reader. It is intended to supply the medical practitioner and pharmacist with not "a long felt want," but one continually felt by each and every physician. The size of the book almost admits it to the vest pocket, and yet the information in regard to new remedies is perhaps more full than may be found elsewhere. The index is most complete, and renders the book instantly available on any topic of which it treats.

THE POCKET PHARMACY, With Therapeutic Index. A Resume of the Clinical Applications of Remedies adapted to the Pocket Case; for the Treatment of Emergencies and Acute Diseases. By John Aulde. M.D., member of the American Medical Association, of the Medical Society of the State of Pennsylvania, of the Philadelphia County Medical Society, etc. D. Appleton & Co., New York.

A pocket medicine case is something every physician should have, and to know how to use and when to use the contents

of this same pocket case is another requisite. After carefully reading this small brochure, we have no doubt but that those physicians who did not know how to use the contents of the case before doing so, will be prepared for almost any ordinary emergency in their practice. The author is a strong advocate of small doses; in this he has our hearty approval. The recent graduate will find the brochure especially useful.

A PRACTICAL MANUAL OF DISEASES OF THE SKIN. By Geo. H. Rohe, M.D., Professor of Materia Medica, Therapeutics and Hygiene, and formerly Professor of Dermatology in the College of Physicians and Surgeons, Baltimore, etc., etc. Assisted by J. Williams Lord, A.B., M.D., Lecturer on Dermatology and Bandaging in the College of Physicians and Surgeons; Assistant Physician to the Skin Department in the Dispensary of Johns Hopkins Hospital. No. 13 in the Physicians' and Students' Ready-Reference Series. In one neat 12mo volume, 303 pages. Extra cloth, price $1.25 net. Philadelphia. The F. A. Davis Co., publishers, 1231 Filbert street.

The eminence in the profession of the compilers of this book should be sufficient guarantee that they have produced a work which will be found instructive reading by the student and practitioner. Brief and exact descriptions of the various diseases considered, and the simplest and most direct methods of treatment are very desirable; and here this feature has been carried out. The needs of the general practitioner have been kept primarily in view.

W. B. Saunders of Philadelphia, the publisher, announces the following important new medical works as in preparation, ready for delivery about June 1, 1892. They will be sold only by subscription.

An American Textbook of Surgery. By Professors Keen, White, Burnett, Conner, Dennis, Park, Nancrede, Pilcher, Senn, Shepherd, Stimson, Thompson, and Warren. It is to form one handsome royal octavo volume of about 1200 pages (10x7 inches), profusely illustrated with wood cuts in text, and chromo-lithographic plates. Price cloth, $7; sheep, $8.

An American Textbook of the Practice of Medicine, according to American teachers, edited by William Pepper, M.D., LL.D., provost of the University of Pennsylvania. This is to appear in two handsome royal octavo volumes of about 1000 pages each, with illustrations to elucidate the text wherever necessary. Price per volume, cloth, $5; sheep; $6.

He also announces a new Pronouncing Dictionary of Medicine, by John M. Keating, M.D., and Henry Hamilton, and a work on Diseases of the Eye, by G. E. de Schweintz, M.D., both to be ready in a few weeks.

NEWS, NOTES AND ITEMS.

A. Conway, M.D., of Lamonte, Mo., writes: For the past year or two I have been using Peacock's Bromides with good success, and from my experience find it the most satisfactory of any of that class of preparations now on the market.

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Pepsin is undoubtedly one of the most valuable digestive agents of our materia medica, provided a good article is used.. Robinson's Lime Juice and Pepsin, and Aromatic Fluid Pepsin (see advertisement), we can recommend as possessing merit of high order. The fact that the manufacturers of these palatable preparations use the purest and best pepsin, and that every lot made by them is carefully tested before offering for sale, is a guarantee to the physician that he will certainly obtain the good results he expects from pepsin.

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THE WORLD'S COLUMBIAN EXPOSITION.-Send 50 cents to Bond & Co., 576 Rookery, Chicago, and you will receive, postpaid, a four hundred page advance Guide to the Exposition, with elegant engravings of the grounds and buildings, portraits of its leading spirits and a map of the city of Chicago; all of the rules governing the Exposition and exhibitors, and all information which can be given out in advance of its opening. Also other engravings and printed information will be sent you as published. It will be a very valuable book, and every person should secure a copy.

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H. C. Buel, Resident Physician Good Samaritan Hospital, Cincinnati, Ohio, writes as follows to the Albemarle Chemical Co. We have been using your Therapine in our hospital, and find it equal if not superior to any other antipyretic and anodyne. Its action is quick and efficient. It is pleasant to take, and, so far as we have observed, has no bad after effects.

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AN INTERESTING CASE.-J. E. Blackshear, M.D., of Macon, Ga., reports the following case: Mr. J. V., a young man, 21 years of age, was first seen July 5th, 1891. Had been for eight months under treatment for syphilis, and all the while growing worse. Was very much prostrated, and was suffering with an immense abscess on the outer portion of the upper