the inflammation, mild solutions of the sub-acetate of lead can be used, which will help keep the urethra clean. A syringe with a short nozzle should be employed, so as to only just enter the meatus. The injection should be of moderate size, so as not to over-distend the urethra. During the acute stages, I instruct my patient to take a warm sitzbath night and morning. When the acute stage has subsided, the administration of some of the so-called blennorrhetics will be found beneficial.

I have found the capsules containing santal-midy, a preparation made from sandal-wood, a very good thing. I consider these superior to the old-time cubeb preparations, which are liable to disturb digestion.-Dr. John A. Wyeth, at the N. Y. Polyclinic, May 23, 1892.

A New, Safe Method of Administering Toxic Medicaments.

A new departure in therapeutical posology marks a recent enterprise of Parke, Davis & Co., which is in the interest of progress, economy, and exactness.

The increased knowledge resulting from research in the fields of botany, chemistry, physiology, pharmacy, and materia medica has created a demand on the part of the medical profession for the essential or active principles of drugs in preference to the more cumbersome, less definite pharmaceutical preparations which custom and authority have so long. sanctioned.

Not a few alkaloidal principles of drugs have been isolated, and are now frequently prescribed. The conservative element of the profession have, however, in view of the toxicity of certain isolated medicinal principles, and the acknowledged variety of strength and activity of products of this character of different manufacture, been loth to employ them when indicated.

The doses sometimes being fractions of a thousandth or a hundredth, it is not possible for the physician to always bear them in mind, and in prescribing he is often in doubt as to what constitutes the proper therapeutical dose, and what the dangerous toxic one.

Dr. E. Trouette, in a paper read before the Paris Academy

of Medicine, and published in the Revue de Therapeutique, entitled "Duodecimal Doses of Toxic Medicaments," proposes a method of obviating the difficulties hitherto preventing the general use of many valuable medicinal principles. The plan he proposes is a new method of posology based on the rational division into twelve parts of the maximum dose which may be given to an adult in twenty-four hours.

The advantages claimed for this method are, first, accidental poisoning need no longer be feared. Second, dangerous medicaments may, from the outset, be given in efficient dose without the least risk.

Parke, Davis & Co. have prepared diurnules and diurnal tablet triturates of a large number of toxic medicaments, and will afford the profession full information concerning this new method of posology with reprint of Dr. Trouette's article.

Analytical Records-Wyeth's Beef Juice.*

The following analytical notes and results testify unmistakably to the excellence of this preparation. It is a dark reddish-brown liquid of pleasant beef-like flavor, and free from objectionable preservative. It contains not only the albuminous principles of beef in an active and soluble form, but in the condition in which they occur in the freshly expressed juice of beef itself. Viewed with the spectroscope a dilute solution is seen to give two absorption bands, characteristic of fresh blood or hemoglobin. The liquid loses this property, however, as soon as it is boiled; while the coagulated albuminous principles assume a blood-red tint. According to our experiments no less than fourteen grains of solid albuminous principles in every fluid ounce are thus precipitated. The following figures gained in analysis will convey some idea of the eminent degree of concentration through which this preparation has been carried. Notwithstanding this, the vital elements of beef juice it contains have been preserved unchanged. Moisture, 44.87 per cent.; organic matter, 38.01 per cent.; mineral matter, 17.12 per cent. The organic materials contain 4.57 parts of nitrogen, and the mineral matter consists

John Wyeth & Brother, Philadelphia.

largely of common salt and, of course, soluble phosphate. Results like these make it safe to assert that as an example of preparations of this class Wyeth's beef juice is little short of perfection.-London Lancet.

The Administration of Iron.

Chalybeate waters have, from remote times in antiquity, played a most important part in therapeutics. In modern times the question has been to produce a ferruginous preparation, which would be easily assimilated. This is a very important problem, because those who are most in need of such tonics have stomachs which are more or less intolerant of the majority of preparations of iron. Children are also prone to rebel against the ordinary ferruginous preparations. So the conditions which must be filled are the following: 1. To supply iron in such a pleasant form that the most delicate constitution will tolerate it; 2, it must be easily digested and assimilated; 3, it must be pleasant to take.

The combination devised by Dr. Nega, and manufactured by Dr. Enno Sander, fills all of these conditions. It is essentially a water containing the equivalent of two grains of metallic iron, combined with phosphoric and alkaline salts, to the pint, it being effervescent in character and proportionally grateful to the palate. The name under which it is introduced is, "Dr. Nega's Sparkling Pyrophosphorous Iron Water," and it is indicated in anemia and debility as well as in many infantile troubles in which iron forms one of the constituents of necessary medication. The water is totally void of any taste suggestive of its ingredients, and, on this account, is readily acceptable to those to whom it is administered. While this water is known to a large number of physicians, many are ignorant of it and frequently experience great difficulty in the proper presentation of iron, a trouble which could be easily avoided by employing Dr. Nega's Iron Water.

For scalds, burns, and frost-bites, Dr. W. T. Collins, in Weekly Medical Review, suggests the application of pure collodion, or collodion two parts to one of castor oil, and as soon as the coating begins to scale off repeat the application and wrap with absorbent cotton or cotton wool. The application of the above after scalds or burns will give instant relief.