to the c.mm.; second count, 3,300,000 to the c.mm. Hemoglobin: first examination, 33 per cent.; second examination, 45 per cent.

Case 6.-A young girl, aged 17 years; dysemia, following typhoid fever. Time of administration, three weeks. First count, 2,495,270 red corpuscles to the c.mm.; second count, 3,300,200 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 35 per cent.; second examination, 45 per cent.

Case 7.-A young boy, aged 16 years; dysemia, following typhoid fever. Time of administration, three weeks. First count, 3,670,000 red corpuscles to the c.mm.; second count, 4,600,300 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 40 per cent.; second examination, 65 per cent.

Case 8.-A man, aged 30 years; dysemia, following amputation of the leg. Time of administration, three weeks. First count, 2,360,400 red corpuscles to the c.mm.; second count, 3,500,200 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 30 per cent.; second examination, 70 per cent.

Case 9.-Woman, aged 24 years; dysemia, following pneumonia. Time of administration, three weeks. First count, 2,600,250 red corpuscles to the c.mm.; second count, 3,400,000 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 35 per cent; second examination, 70 per cent.

Case 10.-Woman, aged 20 years; dysemia, following miscarriage. Time of administration, three weeks. First count, 2,502,600 red corpuscles to the c.mm.; second count, 4,006,200 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 40 per cent.; second examination, 65 per cent.

Case 11.-Man, aged 32 years; dysemia, following typhoid fever. Time of administration, three weeks. First count, 2,300,000 red corpuscles to the c.mm.; second count, 3,640,160 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 33 per cent.; second examination, 62 per cent.

Case 12. A girl, aged 16 years; dysemia. Time of administration, four weeks. First count, 2,290,700 red corpuscles to the c.mm.; second count, 3,800,200 to the c.mm. Hemoglobin (percentage of normal amount): first examination, 40 per cent.; second examination, 60 per cent.

ence.

Case 13.-A girl, aged 16 years; dysemia. Time of administration, four weeks. First count, 2,430,300 red corpuscles to the c.mm.; second count, 4,000,300 to the c.mm. Hemoglobin (percentage of normal amount) first examination, 40 per cent.; second examination, 65 per cent. Comparing my results with Pepto-Mangan (Gude) with those obtained from other chalybeates of this class, I have been led to give it decided preferAs already stated, the only reliable means of diagnosticating dysemia is by the examination of the blood, and for the same reason the only way of testing the efficiency of a ferruginous preparation is by making bloodcounts and estimating the percentage of hemoglobin. On the ground of my findings, as shown by the histories of the cases cited, the results of such tests have been uniformly satisfactory and entitle the preparation to a leading place in ferruginous medication.-Buffalo Medical Journal.

BLOOD REGENERATION THE RATIONALE OF THE TREATMENT OF ANEMIA BY IRON AND ARSENIC.

FOR a great many years a combination of iron and arsenic has been a favorite tonic and hematinic with most practitioners, and it is a well demonstrated fact that many cases failing to respond to iron alone will promptly improve when some form of arsenic is added to the treatment, and vice versa. The true scientific explanation of the conjoined action of these drugs has been but recently appreciated, although they have long been thus employed empirically with marked success. According to an eminent Italian authority, Aperti, who has carefully investigated the subject by means of animal experimentation, two things are essentially necessary for the regeneration of the blood: 1. Restitution of the protoplasm of the red cells. 2. A supply of iron for the production of hemoglobin. Repeated experiments show that arsenic increases the number and builds up the structure of the red corpuscles, and that iron, when given in absorbable shape, induces the formation of hemoglobin. Each of these substances, therefore, when prescribed medicinally, has its separate and specific effect upon the blood, both being necessary if a prompt hematinic action is expected. A further step toward a rational explanation of the value of arsenic in anemic conditions has recently been taken by Armand Gautier, who has shown conclusively that this substance is normally present in appreciable quantity in several of the body tissues, notably the thyroid gland, brain, thymus and skin. As in the case of the normal iron content of the body, which is contributed to the organism through the foodstuffs, the source of the arsenic is supposed to be certain aliments. After ingestion and absorption it is taken up by the blood and fixed in the nuclei of the cells, where it is found combined with nucleins. In other words, the normal arsenic supply of the organism comes to it in organic combination only, just as the ferruginous elements are supplied by nature in organic combination with the nucleo-albumens of the vegetable kingdom. Both chemists and clinicians are now pretty well persuaded of the more prompt and ready absorbability of true organic iron as compared with the mineral salts of this metal, which must cause irritation of the digestive tract as a prerequisite of absorption. Hemaboloids Arseniated (with strychnia) not only furnishes the physician with a preparation of organic iron-bearing nucleo-albumens, but also contains a true nucleate of arsenic, a definite organic chemical combination and not a mere mixture of arsenic and nuclein. The strychnia in this combination, by its immediate toning effect upon the heart, circulation and nervous system, paves the way, as it were, for the more prompt absorption of the real blood-building constituents, iron and arsenic; the tissues are directly fed by the nutrient beef peptones of the Hemaboloids, and leucocytosis is stimulated by the nuclein and extract of bone marrow, added by way of reinforcement.

Hemaboloids Arseniated (with strychnia) finds its special therapeutic field in the treatment of the more severe forms of blood impoverishment, especially the secondary anemias of tuberculosis, rheumatism, gout, syphilis, Bright's disease, etc. As the result of careful research Martinet has recently recommended iron and arsenic combined, for the purpose of combating the profound anemia met with in many cases of sub-acute or chronic pulmonary

HE secret of the great success attending the use of the

66

‘Allenburys" Infants' Foods lies in the easy adaptability
of the "series" to the developing digestive tract.

"No. 1" of the series, which is intended for use during the
first three months of life, approximates very closely in chemical
composition to the milk of a healthy mother, and has been found
as easy of assimilation.

"No. 2" is similar to "No. 1" but contains, in addition, certain quantities of maltose, dextrin and soluble phosphates, to supply the growing demands of the infant. This is designed for use from the third to the end of the fifth month.

In order to meet the still further requirements of the child
after this period the
No. 3" Food is provided.

The series is so arranged that each Food affords the maximum amount of nourishment which the organs of the child, at the period for which it is intended, can with perfect ease digest, and we are constantly receiving evidence of the great value of our system of infant feeding through letters, not only from parents, but from prominent members of the medical profession also, telling us of the gratifying results attending their use, even in cases apparently hopeless and after many other artificial foods and modified milk had been tried.

Samples sent on request.

THE ALLEN & HANBURYS CO.,
Co., Limited

When writing advertisers, please mention THE CANADIAN JOURNAL OF MEDICINE AND SURGERY,

tuberculosis, especially in the slow apyretic form in which the tuberculous process is inclined to affect the lymphatic system. Hemaboloids Arseniated (with strychnia) is the ideal method of administering these agents in such cases. Hemaboloids Arseniated (with strychnia) is also indicated in pernicious anemia, leukemia and other progressive conditions associated with blood destruction and in chronic malarial cachexia, resistant to the antiplasmodial action of quinine. The preparation is especially adapted to the treatment of chorea in children, as it furnishes both the essential drugsiron and arsenic-in palatable, bland and readily absorbable form. Each tablespoonful of Hemaboloids Arseniated (with strychnia) represents the equivalent of 1-40 grain arsenious acid and 1-80 grain strychnia. The dose is one tablespoonful three or four times a day, children in proportion.

PROTAN, A NEW INTESTINAL ASTRINGENT.

PROTAN is a definite chemical compound formed by the synthesis of tannie acid with nucleo-proteid. Protan contains 50 per cent. of tannic acid. It forms a light brown powder, is tasteless, odorless and entirely free from astringent action upon the mouth and stomach. It is insoluble in water, acid solutions or the gastric juice; does not coagulate albumen nor precipitate pepsin peptones.

Protan is unaffected by the gastric juice, and passes through the stomach chemically unchanged; it is, therefore, entirely free from deleterious action upon the stomach and processes of indigestion.

Protan first evolves its active astringent ingredient-tannic acid-when it reaches the small intestine and comes in contact with the alkaline pancreatic juice. Free tannic acid is but very slowly evolved from Protan as it passes downward through the intestines, so that its astringent action is manifested throughout the entire intestinal canal. This fact is verified by the appearance of minute quantities of both Protan and tannic in the feces.

Protan owes its influence to the presence of tannic acid so combined that this body reaches the intestines chemically unchanged. The astringent action of tannin, as all authorities agree, is due to the fact that it precipitates (coagulates) the albuminoid bodies of mucous membranes, which coagulation leads to an actual shrinkage of the structures, with constriction of the capillaries and diminution of secretion. When tannic acid is administered by the mouth these changes take place in the stomach, so that not only is the gastric mucous membrane and the processes of digestion seriously impaired, but the tannic acid is decomposed by the gastric juice into the gallic and pyrogallic acids, which are non-astringent; hence, very little, if any, of the tannic acid reaches the intestines in a chemically-unchanged (astringent) form and presents to the intestinés a definite amount of tannic acid, chemically unchanged and actively astringent. The well-known properties of tannic acid towards albuminoid bodies are here manifested: The growth of bacteria is hindered, their toxins rendered inert, the intestinal mucous membrane is contracted, covered with a superficial coagulum, the capillaries constricted and the exudation of leucocytes prevented. Thus is explained the remarkable clinical value of Protan in all catarrhal and ulcerative conditions of the intestines, associated with diarrhea.