New Instruments. The above are illustrations of the Lynch Aseptic Syringe-Container, an original device for storing and ministering serum, and more particularly diphtheria antitoxin. The barrel of the syringe is filled with serum in the laboratory and aseptically sealed with rubber stoppers. The serum is never again exposed, nor is breakage, with its attendant danger of particles of glass, necessary. The needles and rubber bulb (one of each accompanying every dose of serum) are supplied in sterile wrappings, and as will be seen by the illustrations it is only necessary for the physician to pierce the stoppers with the needles to have a perfect hypodermic syringe. A feature of the device is that half of the contents of the container may be administered, when, by withdrawing the needles the apertures in the stoppers will close, keeping the remaining serum intact and sterile. Dr. H. M. Alexander & Co. have adopted this device as a carrier for their diphtheria antitoxin, which is also supplied by Messrs. John Wyeth & Bro., as authorized general distributers. Loefflerbacilli. The glands of the neck were enlarged. A diagnosis of scarlet fever was made. Owing to the weakened state of the child, sepsis was feared, and hence I injected 20 c.c. of Aronson's antistreptococcus serum on February 15, 1903. The usual aseptic method was thoroughly carried out to avoid local infec The child's condition improved gradually and continuously. The most marked effect in this case was apparent, first, in the reduction of the temperature by lysis, and, secondly, in the gradual melting away of the pseudomembranes (scarlatinal necrosis). At the time of writing (it is now the commencement of the third week) there has been no disturbance nor complication. The kidneys are active. There is no evidence of nephritis. Daily examinations of the urine have been made. As this child has rickets and is in a subnormal condition, I would not have been disappointed to find some toxic disturbances. I therefore feel inclined to give the serum the credit for this convalescence. Desquamation appeared about the fifth day after the injection. Case II.-Hannah S., eight years old, was first seen by me February 20, in consultation with Dr. L. Kohn. The history given me by Dr. Kohn was that the child had been sick three days with a temperature of 104 degrees F. the day previous and 104 degrees F. today. The pulse was weak and rapid. Large necrotic patches covered the entire surface of the pharynx, tonsils, and uvula. There was a marked fetor of breath. A very intense eruption covered the entire body. There was loss of appetite and a general apathetic condition. At the time of the injection of the serum, the following condition was noted: Temperature, 104 1-5 de grees F. pulse, 158; respiration, 26. Owing to the severe general infection, I decided to give an injection of 20 c.c. of antistreptococcus serum. On February 23 I saw the case a second time with Dr. Kohn and noted the entire disappearance of the necrotic patches in the throat. This condition is identical with that noted in Case I. Dr. Kohn told me that this condition was already apparent on the third day after the sereum injection. The deductions after Baginsky's experience with this new serum were that "no secondary ill effects were noticed." The fever, even in severe forms of the disease, declined steadily and continuously without interruption by complications. Baginsky reported a series of observations, and demonstratede fever charts showing the gradual decline after comparatively small doses of serum. In some instances, two, rarely three doses of 20 c.c. each caused the gradual decline of the disease. All in all, Baginsky maintains that with the exception of "serum rashes," there are no disagreeable effects from this new serum. Great care should be exercised in judging this new serum from a small although a successful, series of cases. The specific action of antitoxin in diphtheria is far greater comparatively than the action attained from the use of this antistreptococcus serum. It is too soon to formulate definite conclusions based on an experience of two cases. The clinical results were certainly striking. The effect of the serum on the temperature shows that it did inhibit bacterial products. Another interesting observation in both cases is the disappearance—almost melting away-of the necrotic membranes after the fourth day. The temperature came down gradually by lysis. There was no crisis which could be distinctly noted, although Case I. showed a marked antithermic result of the in and ECTHOL, NEITHER ALTERATIVE NOR ANTISEPTIC SAMPLE (12-oz.) BOTTLE SENT FREE ON RECEIPT OF 25 CTS. FORMULA:--Active principles of Echinacia and Thuja. CHEMISTS BROMIDIA BATTLE & CO., CORPORATION. ST. LOUIS, MO., U.S. A. Samples Literature supplied by B A AGURIN The Non-Irritating Diuretic. EPICARIN PRODUCES The Non-Toxic Dermal Parasiticide. SALOQUININE The Tasteless and Improved Quinine.. BAYER HEDONAL E MERIKEN The Promoter of Natural Sleep. FERRO-SOMATOSE PROTARGOL The Ferruginous Nutrient and Tonic. ASPIR Antigonorrheal, Antiseptic The Best Salicylate jection. The glands of the neck in both cases were swollen and subsided with the disappearance of the throat manifestations. The vital point consisted in a strengthening diet in addition to strict hygiene. Thus I feel warranted in indorsing the view expressed by Baginsky, advocating the use of this new serum in the treatment of scarlet fever. 2 LITERATURE. 1 Transactions Berlin Medical Society. 1896 Section of Pediatrics New York Academy of Medicine, May 12. 1898. Paper published in "Archives of Pediatrics," July, 1898. 3 Berlin Medical Society. Bd. 23. p. 8. 4 "Berliner klinische Wochenschrift." 1900, 27 and 28. Aronson. "Antistreptokokken-Serum." in "Berliner klinische Wochenschrift," October 27. 1902. Transactions Berlin Medical Society (Aronson), July 16. 1902. Marmorek, "Berliner klinische Wochenschrift," November 14, 1902. "Indian Medical"---The King of Spring Waters An Absolutely Pure Product of Nature Indian Medical Spring Water has the unqualified endorsement of the medical profession, and is recommended as a positive preventive of typhoid fever, if used exclusively, and as a cure for rheuma tism, kidney disease, eczema and all of the allied diseases of the bladder and stomach. It acts especially upon the gastric juices, aiding the assimilation f food and producing new blood, which no medicine will do. For further information and prices, call on or address, INDIAN MEDICAL SPRING WATER CO. 604 Masonic Temple, MINNEAPOLIS, MINN. 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