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In order to prove the efficiency of GLYCOZONE, I will

send a

$1.00 bottle free

to Physicians accompanying their request with 25c. to pay
forwarding charges.

A copy of the 18th edition of my book of 340 pages, on the
"Rational Treatment of Diseases Characterized by the Pre-
sence of Pathogenic Germs," containing reprints of 210 un-

Prepared only by

Charles Marchand

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solicited clinical reports, by leading contributors to Medical Chemist and Graduate of the Ecole Centrale des
Literature, will be mailed free of charge to Physicians
mentioning this Journal.

Arts et Manufactures de Paris (France) 57-59 Prince Street, NEW YORK.

Look well to your prescriptions-a careless or dishonest pharmacist may ruin your reputation.

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Highly Recommended in all STOMACH TROUBLES Particularly The Vomiting of Pregnancy Specimen to Doctors on Request




(Each Tablespoonful contains 2 minims of Creosote and 8 grains of Hydrochloro-phosphate of Lime.)



(Each capsule contains: Iodoform, 0.02 centigrammes; Phosphate of Lime, 0.15 centigrammes
Creosote, 0.05 centigrammes.),

Successfully Prescribed by Best European Doctors for 25 years, in all kinds of Tuberculous Affections, especially those of the Lungs and Bones, Chronic Bronchial and Pulmonary Affections, Convalescence from Pleurisy and Broncho-Pneumonia, Influenza, Measles, Whooping-Cough, Scrofula and Rickets. Dollar Bottle to Physicians willing to pay expressage.

GEO. J. WALLAU, Special Agent, 2 Stone Street, NEW YORK.


Blancard's Pills BLANCARD'S



Endorsed by Paris Academy of Medicine.

Indicated in Anemia, Leucorrhea, Amenorrhea, Constitu-
tional Syphilis, etc.
Dose: 2 to 6 pills per day.

Samples to Physicians upon receipt of professional card.

GEO. J. WALLAU, U. S. Agent, 2 and 4 Stone Street, NEW YORK, N. Y.

40 Years Standard of the World Gold Medal, World's Fair, St. Louis.



and you will agree with all FRENCH PHYSICIANS that it can be recommended as an ABSOLUTELY PURE AND HYGIENIC COLD CREAM

in all minor skin ailments.

A Sample Jar for the asking.


2 and 4 Stone Street, New York City.

Suitable for children and persons who cannot swallow pills.

Dose: 1 to 3 tablespoonfuls.







Perfectly tolerated even by young children.
1 gr. of lodine combined with Tannin per teaspoon.
All the Indications of lodine.
DOSE-2 to 4 teaspoonsful and more, per diem.
Samples and literature to Physicians on request.

GEO. J. WALLAU, Agent, 2 & 4 Stone St., N. Y.


Have used and prescribed resinol ointment and soap with very satisfactory results. Last case was one of eczema on face and shoulders, and of several years standing. The trouble has entirely disappeared with the use of one jar of ointment and one cake of soap.—Chas. Hubley, M. D., New York City.

Never Without Calcidin.—I have the highest regard and praise for calcium iodized -calcidin (Abbott) having in my own simple way no doubt saved the life of a child twenty months of age (one of twins)-croup complicated with congestion of lungs. The condition was grave: temperature 105.6; one convulsion after the other. The condition, as it was found, had been existing only six hours before my arrival. I ordered calcidin every ten minutes for two hours, then every thirty minutes with calomel, gr. 1-10, every thirty minutes; hot foot bath, in fact above hips; cold applications to head and neck, I expected the child to die, so did the parents when they called me. I returned in six hours. Temperature 101.8 and breathing very good indeed. In one week the child was well. Two years before I had a case exactly like this one, I have particulars, and the child died eight hours after I saw her. I think I am safe in saying I was the means, with the aid of calcidin and Nature, in bringing back the life that was fast coming to a close. I shall always use it. I am never without the drug a minute.—Dr. Frank S. Myers, Youngstown, Ohio.


A stands for Andes, the mountains so high.

B for the breezes which blow through the sky;

C stands for Coca-both Co and the Ca

D "Divine Plant"-it was named by Inca.

E is the earth 'neath the clouds, far below,

F for the forests near where the shrubs grow;
G the gray rocks over which the mule packs
Huge bundles of Coca done up in sacks.

I for the Indian, without food or drink,
Jogging, untired, 'round high mountain's brink.
K is for Koller, with drop in the eye,
Learning new uses for Coca to try.
M. Mariani first made Coca wine.
Niemann's the chemist who found cocaine:
O for the ore, and some other things, too,
Plentifully found in the land of Peru.

Q is the Quichua Indian race,

Round as to limb but of angular face;

S for the strength of this plodding man, who
Travels all day with but Coca to chew.
U stands for you, if you will but admit
Vin Mariani has made a great hit;
Wine make with Coca-a tonic unique-
Xcellent both for the well and the weak.
You'll find it endorsed full fifty years through;
Zealously hold then, that found to be true.
The Coca Leaf, September, 1905.

The Treatment of Cough.-Cough, regardless of its exciting cause, is a condition that every physician experiences more or less difficulty in relieving. While the agents designed for its relief are numberless, it is a matter of common knowledge that but few of them are of general utility for the reason that although they may be capable of effecting relief, and in doing so they either derange the stomach, induce constipation, or cause some other undesirable by-effect. The ideal cough cure must combine sedative and expectorant properties without exhibiting the slightest systemdepressant, gastric-disturbing, constipation-inducing or palate-offending action. Nor should it contain any ingredient the prolonged use of which would cause a drughabit. Then too, it must be of sufficient potency to produce the desired effect with the utmost promptness, for, in many instances the patient has indulged in self-drugging to a certain extent before consulting the physician; hence, it is directly to the interest of the practitioner to demonstrate his skill by immediately relieving the disturbing condition. It is now universally conceded that glyco-heroin (Smith) is the ideal cure for coughs of all varieties. This product embraces the most active sedatives and expectorant agents in the exact proportions in which they exhibit their greatest remedial potency. It matters not what the exciting cause may be, the effect of this preparation is always immediate, pronounced and extremely agreeable. The cough is almost instantly suppressed, the expulsion of the accumulated secretions is stimulated, respiration is rendered free and painless and the inflammation of the lining of the air-passages is speedily allayed by its use. Glyco-Heroin (Smith) may be administered for an indefinite length of time without any depreciation in its curative properties and without the induction of a drug-habit. It is of especial value in the treatment of pulmonary phthisis. It is pre-eminently superior to all preparations containing codeine or morphine.

Mucous Plaques: Prophylaxis and Treatment.-(By Edward H. Skinner, M. D.' Kansas City, Mo.) The proper care of the mouth is a matter of importance in the control of the secondary symptoms of oral syphilis, especially in view of the fact that the average leutic patient has all too little regard for any hygienic measures. In anticipation of the early onset of the secondary oral patches it should be the duty

of the physician to instruct his patients as to the proper prophylactic measures to be adopted that the severity of these symptoms may be ameliorated. The first thorough examination of the new leutic case should include the careful examination of the mouth and teeth. If we feel incompetent to judge of the conditions of the teeth we should refer the patient to the dentist. The roughened edge of a tooth, or an unfilled cavity, may serve as an irritant in establishing a mucous patch. The dentist will instruct the patient as to the proper care of the teeth. The cleaning of the teeth after meals, to avoid the accumulation of debris,should be impressively taught, We should also realize that the salivation may best be avoided by the attention to the condition of the teeth and gums. Anticipating the secondary symptoms we usu ally attempt to promote the general health of the individual by tonics and bodily hygiene. We should also try to increase the cellular resistance of the buccal membrane by local measures. It may be well to consider means to this end at this time. Bartholow considers a number of drugs to be used locally. Hydrastis canadensis is

recommended as a stimulant to mucous membranes. It also has a valuable astringent quality and promotes the salivary secretions. Hamamelis virginica is also valuable in advancing the prophylactic powers of the mucous membranes. Thymol and menthol have valuable properties, influencing fermentation and putrefaction, and also serving as antiseptics. They allay the sensibility of the mucous membranes and arrest the retraction of the gums. Boric acid has decided antiseptic and deodorant properties. This acid was an important factor in the original Lister antiseptic method. Being very mild, it may be used in varying strengths without danger. Glycerine has a beneficial effect on all mucous membranes,inasmuch as it dehydrates and soothes any tissues it may touch. Combinations of the above remedies may be made that will serve not only as valuable prophylactics, but also as curative agents in any inflammation of the mucous membrane. But we should remember that the application will avail little if the patient does not assist their action by the careful cleansing of the mouth and teeth at frequent intervals, not being afraid to use the greatest remedy of all-pure water. When once the mucous patch has asserted itself we should try to avoid the ulcerating and sloughing process that accompanies the oral syphilide. It is at this time that our prophylactic measures show their true worth. The mucous patch rarely spreads in the clean mouth. Foul secretions and decomposing food stuff favor the ulceration of the patches. The best local application for a patch is the silver nitrate pencil. One application a day will usually suffice. An antiseptic mouth-wash should be used by the patient about every three hours during the day. Among the various combinations on the market today one will find that katharmon offers advantages. The internal administration of mercury should be pushed. If we find that the patches persist in spite of the above treatment we should try a short regime of the iodides. Very frequently the stubbornness of the oral features of syphilis may be due to the mercury treatment. It is in these cases that the withdrawal of the metal and the substitution of the iodide, with the use of remedies to cure the ptyalitic symptoms, will afford relief.

Substitution in Medicine.—In a recent case of death from poisoning, the druggist who gave the wrong medicine offered as an excuse that he had merely substituted one article for another on the supposition that it was of equal strength and much cheaper. The prescriber, in testifying on the trial, stated that the practice was a very dangerous and very frequent one, and was apparently past remedy. While the latter may or may not be the case,it is quite certain that with many who claim to be reputable and competent pharmacists the practice of substitution is very common. The number of protests made from time to time in medical journals have reference to only a small percentage of offenders, inasmuch as the larger number of such do not happen to be discovered. The question of prevention, however, is a very serious one from every point of view. The physician, in his direct and responsible connection with the trustful patient is the one most concerned, although drug manufacturers also have a right to claim fair play regarding the guaranteed qualities of their products. With both parties it should be the real thing or nothing. From the business point of view it is a fraud on the producer, and, from the ethical view, a danger to the consumer. Both parties in the compact have thus a common cause against the middle-man who surreptitiously plays the part of thimble-rigger and steerer. The temptation to substitution is always strongest with the most expensive medicaments, and in the case of such as have a known quality of efficacy. An inferior, and oftentimes inert, article is almost invariably used when substitution is practiced. Thus the manufacturer and the prescriber are always placed in a false light with the patient, who expects certain promised results. Generally speaking, the physician is the one to suffer most, as his disappointed client is apt to leave him for another. How many lost patients can be accounted for in this way it would be difficult to imagine. The too trustful physician is in a very bad way between the prescribing druggist on the one hand and the ever-ready substitutor on the other. Must he be compelled to turn dispenser himself in sheer defense? Certainly, in some cases, the crime has in this way met its penalty. But when we look about for a remedy against the evil we butt against the bulwark of general depravity and the impossibility of applying ordinary missionary efforts. The only thing is to discover and then to punish. The man who substitutes will do so again. He has no conscience to begin with and nothing, in fact, to which an appeal can be made. The whole question then narrows itself down to that of mutual trust and the dispensing of original unbroken packages.-Medical Record.

Vol. XXX


Papers for the original department must be contributed exclusively to this magazine, and should be in hand at least one month in advance. French and German articles will be translated free of charge, if accepted.

A liberal number of extra copies will be furnished authors, and reprints may be obtained at cost, if request accompanies the proof.

Engravings from photographs or pen drawings will be furnished when necessary to elucidate the text. Rejected manuscript will be returned if stamps are enclosed for this purpose.


ALBERT ABRAMS, M. D., San Francisco.
M. V. BALL, M. D., Warren, Pa.
FRANK BILLINGS, M. D., Chicago, Ill.
CHARLES W. BURR, M. D., Philadelphia.
C. G. CHADDOCK, M. D., St. Louis, Mo.
S. SOLIS COHEN, M. D., Philadelphia, Pa.
N. 8. DAVIS, M. D., Chicago.

ARTHUR R EDWARDS, M. D., Chicago, Ill.
FRANK R. FRY, M. D., St. Louis.

Mr. REGINALD HARRISON, London, England.
RICHARD T. HEWLETT, M. D., London, England.
J. N. HALL, M. D., Denver.

HOBART A. HARE, M. D., Philadelphia.
CHARLES JEWETT, M. D., Brooklyn.

THOMAS LINN, M. D., Nice, France.

E. E. MONTGOMERY, M. D., Philadelphia.
NICHOLAS SENN, M. D., Chicago.

EDWIN WALKER, M. D., Evansville, Ind.
H. M. WHELPLEY, M. D., St. Louis.
WM. H. WILDER, M. D., Chicago, Ill.





THERE are many asthmatics who obtain almost immediate relief from a certain Amer

ican proprietary remedy employed as a nasal spray. I have never prescribed a remedy, the ingredients of which were unknown to me, hence my acquaintance with this particular spray, has been achieved by contact with asthmatics, who employed it to the exclusion of everything else. I sought to dissuade them from using it, knowing fully well that it contained cocain, and that its employment would engender a habit. My efforts in this direction, however, proved unavailing. They argued, that its continuous use provoked no habit, for the reason, that notwithstanding its persistent use, no augmentation of dosage was necessary to secure relief. It was quite evident, that unless I could substitute a legitimate agent for the one in question, all my admonitions would pass for naught to the suffering mortal, who reasonably declined to have ache charmed with air and agony with words. It has been my constant endeavor to fathom the nature of

No. 10

this proprietary remedy, and failing in this, I hope to interest others in investigating this subject. Therefore, I will in this contribution succinctly summarize the results of my observations. The arrest of an asthmatic paroxysm by means of a nasal spray possesses a distinot advantage over the inhalation of the smoke of various antispasmodic agents. The inhalation of the latter permits of the entrance into the bronchial tree of adventitious substances which maintain what I am pleased to call a "foreign I have seen many inbody bronchitis.' tractable cases of bronchitis associated with asthma which have evanesced after the disuse of smoking antispasmodics, and it is quite evident to me, that in many instances where bronchitis survived the cured asthma, the former was originally provoked by the inhalation of antispasmodic remedies. Analyses have repeatedly been made of the proprietary remedy in question. An old analysis by Aufrecht, demonstrated the presence of the following:

Cocaine mur. Kalii nitrio. Glycerin...


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Plant extracts (stramonium). 4%

A more recent analysis by Bertram (Medizin. Klinik, April 9, 1905), shows it to consist of an aqueous glycerine solution of natrium nitride 4%, atropin sulphate (about 1%) and a not determined plant extract. From the analyses thus far made, there is always an hiatus, the mythical something which is stigmatized as a plant extract. Bertram suggests the following cheaper substitute for the proprietary remedy:

Atropin sulphat ..... 0.15
Natrii nitrosi.




Aq. destill..........15.0

M. S. Atomize for three minutes in each nostril and inspire deeply.

The use of the latter formula in my experience has been found disappointing and is in no wise fitted to supplant the proprietary remedy.

Having concluded that the analyses thus far published must be erroneous, for the reason that their employment was without appreciable results, I approached a solution of the problem in another direction, viz., the de

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